University Of Minnesota

This study tests if a single high dose of an antifungal drug works better than the standard daily dose for treating moderate to severe histoplasmosis, a serious lung infection. It also compares a newer oral drug to the standard one, and checks if 6 months of treatment is as good …

This early-stage study will test a new way of using deep brain stimulation (DBS) for Parkinson's disease. Instead of the usual constant high-frequency pulses, this 'Coordinated Reset' approach uses lower-power, patterned stimulation. Researchers want to see if it's safe and can i…

This Phase 2 trial tests an oral antifungal drug called oteseconazole in adults with dimorphic fungal infections, including coccidioidomycosis, blastomycosis, and histoplasmosis. Participants must already be on antifungal therapy but need a different option because standard first…

This study tests whether a daily drink containing specific amino acids can reduce infections, improve bone healing, and prevent muscle loss after surgery for severe leg fractures. About 1,000 adults aged 18–55 with lower leg fractures will receive either the supplement or a place…

This trial is testing whether a 10-week course of fluconazole works as well as the standard 24-week course for people with HIV who have a cryptococcal infection in their blood (antigenemia) but no symptoms. It also compares starting HIV medications right away versus waiting 14 da…

This trial asks whether tailoring a pacemaker's lower heart rate to each person—rather than using a standard fixed rate—can improve cognitive function and overall health status in people with symptomatic bradycardia (a heart rate that is too slow). About 110 adults who need a per…

This early-stage trial tests whether transplanting gut bacteria from healthy donors, along with antibiotics and fiber, is safe and feasible for people with pulmonary arterial hypertension (PAH), a condition of high blood pressure in the lungs. About 24 adults with PAH will be ran…

This study looks at whether adding lifestyle coaching to a new weight-loss medication (GLP-1) helps teens with obesity lose more weight and feel better. About 1,020 teens aged 12-17 will take the medication and be assigned to either intensive or basic lifestyle support. The goal …

This pilot study tests whether repetitive transcranial magnetic stimulation (rTMS) can strengthen a brain circuit linked to staying away from cannabis. Fifty treatment-seeking youth aged 15–21 with cannabis use disorder will receive either real or sham rTMS. Researchers will chec…

This early study will test a new way to use deep brain stimulation (DBS) in 4 adults with Lennox-Gastaut syndrome, a severe form of epilepsy. The device will automatically adjust stimulation based on whether the person is awake or asleep. Researchers want to see if this personali…

This study adapts an existing smoking cessation program (CEASE) for Somali immigrant parents who smoke. Researchers will test whether brief counseling, nicotine patch prescriptions, and quitline referrals delivered during pediatric visits can help parents quit. The study enrolls …

This study tests whether the drug Qsymia, combined with lifestyle coaching, can prevent obesity in 140 adolescents and young adults (ages 18-25) who are overweight (BMI 25-30) and have a family history of obesity. Participants will receive either Qsymia or a placebo, plus coachin…

Very preterm infants often leave the neonatal intensive care unit with developmental needs that continue at home. This study tests whether a program called SPEEDI can be delivered to families in the first weeks after NICU discharge. Parents learn to read their baby's behavioral c…

This study tests whether applying local heat to the jaw can reduce pain and fatigue caused by teeth clenching in people with chronic temporomandibular disorder (TMD). Ten adults with TMD will receive heat therapy and report their pain levels daily for 8 days. Researchers will com…

This pilot study tests a smoking cessation approach that combines mindful smoking practice with a smartphone-based sensor-band. Adults who smoke at least five cigarettes a day will be randomly assigned to either receive the mindful smoking intervention plus standard quitting info…

This trial tests a mobile app called the Social Reminder System, designed to help people with memory concerns stay socially engaged. The app sends reminders on a home tablet when a trusted friend or family member is nearby, potentially encouraging more visits and interactions. Re…

This early study tests a brain stimulation device for people with long-term nerve pain that hasn't responded to other treatments. The device is surgically placed to send mild electrical pulses to specific brain areas. The main goal is to see if the procedure is feasible and accep…

This study will use advanced MRI scans to look at kidney transplants in 140 patients. The goal is to see if MRI can measure how well the kidney is working and tell the difference between stable function and problems like rejection. Researchers hope this could lead to a non-invasi…

Researchers at the University of Minnesota are studying why chronic pain varies so much from person to person. The study enrolls 400 adults with chronic low back pain or spinal cord injury-related neuropathic pain. Participants answer brief surveys four times a day for at least t…

This study uses a special dental MRI to watch how local anesthesia affects the mouth during dental procedures. About 102 adults will have their numbness and sensation tested right after numbing and again one hour later. The goal is to see if MRI can help measure how well dental n…

This pilot study is testing whether wearable patch monitors can help detect heart problems early in adults undergoing treatment for breast cancer, blood cancers, or multiple myeloma. Participants will wear two patches—one that tracks heart rhythm continuously and another that rec…

This study tests a new handheld device called the Dinomometer, designed to measure grip strength in children ages 2 to 12. Researchers will collect data from about 600 kids at the Minnesota State Fair to establish normal grip strength values. The goal is to create reference stand…

This study looks at how the amount of phosphorus in food affects phosphorus and calcium balance in people with moderate chronic kidney disease (CKD). Fourteen participants will follow two different controlled diets (low phosphorus then high phosphorus, or vice versa) for 19 days …

This study tests whether a multi-day training program can reduce stigma that doctors in Vietnam show toward people with HIV and men who have sex with men. Researchers will send trained actors ("standardized patients") to clinics to pose as real patients and measure how doctors tr…

This study investigates whether computerized cognitive training can change brain metabolism and excitatory/inhibitory balance in adults with schizophrenia. Participants will undergo brain imaging and EEG before and after about 10 hours of either perceptual discrimination or cogni…

This study will test whether a noninvasive device can accurately measure how much oxygen is being delivered to the body during heart surgery. Researchers will compare readings from the new monitor to those from standard invasive catheters in 150 adult patients. If the new method …

This study tests a new way to deliver two common Parkinson's medications, carbidopa and levodopa, using a small pouch placed between the cheek and gum. The pouch releases the drugs slowly, allowing absorption through both the cheek lining and the stomach. Researchers are measurin…

This study looks at whether shifting text to a different part of the eye can help people with central vision loss read faster and more accurately. Researchers will test 100 participants with conditions like macular degeneration using various reading tasks. The goal is to find bet…

This study tests a method to help clinics prescribe long-acting injectable PrEP, a shot that prevents HIV. Researchers will work with 20 healthcare providers and staff to improve how they offer this option. The goal is to see if a simple, flexible strategy can increase the number…

This study aims to develop and test advanced MRI methods to study kidney disease, including in patients with chronic kidney disease, those on dialysis, and kidney transplant recipients. Researchers will also use brain MRI to explore links between kidney function and cognitive pro…

This study looks at how cystic fibrosis medications (CFTR modulators) change in the body during pregnancy and after childbirth in 30 women. Researchers will measure drug levels in blood, breast milk, and umbilical cord blood. The goal is to understand how these drugs work in preg…