University Of Minnesota

This early-stage trial compares an experimental flu vaccine (H1ssF) with the standard seasonal flu shot (Flucelvax) in 112 adults aged 18-70. Some participants have had flu shots before, while others have never been vaccinated. The main goal is to check safety and how the immune …

This study looks at how much lifestyle support teens with obesity need when they also take new weight-loss medications. About 1020 teens aged 12 to 17 with a BMI in the 95th percentile or higher will join. Researchers will compare a low-intensity program (less than 26 hours) to a…

This early study tests a new deep brain stimulation (DBS) approach that adjusts stimulation based on whether the person is awake or asleep. Four adults with Lennox-Gastaut syndrome will receive a Medtronic Percept DBS device. Researchers will compare personalized day/night stimul…

This study tests a new combination of antibiotics (BPaLMZ) against the standard treatment for tuberculous meningitis, a serious brain infection. About 240 adults, including those living with HIV, will take part. The goal is to see if the new combo reduces deaths and improves reco…

This study tests whether taking an oral supplement with certain amino acids after leg fracture surgery can lower the risk of infection, poor bone healing, and muscle loss. Researchers will compare the supplement to a placebo in 1,000 adults aged 18-55 with leg fractures. The supp…

This study tests whether empagliflozin, a diabetes drug, can improve blood sugar control in people who have had islet transplants but still have partial pancreas function. About 40 adults will take either a placebo or one of two doses of the drug for 3 months. The goal is to see …

This study adapts a proven smoking cessation program for Somali immigrant parents who smoke. About 50 parents will receive coaching, nicotine replacement therapy, and referrals to quitlines during their child's pediatric visit. The goal is to help parents stop smoking and reduce …

This study tests if a single high dose of an IV antifungal works as well as the standard daily dose for treating moderate to severe histoplasmosis, a serious lung infection. It also compares two oral medications and shorter treatment duration (6 vs 12 months) for people with HIV.…

This early-stage study tests a new way to deliver deep brain stimulation (DBS) for Parkinson's disease. Instead of constant high-level pulses, 'Coordinated Reset' DBS uses lower, patterned stimulation. Researchers will check if it is safe and can improve movement in 24 adults alr…

This study tests a new diet designed to meet the protein needs of people with ulcerative colitis while reducing harmful gas (hydrogen sulfide) made by gut bacteria. Researchers will measure gas levels in stool samples from 40 adults with mild to moderate disease. The goal is to s…

This study aims to prevent obesity in adolescents and young adults (ages 18-25) who are at high risk due to family history and higher starting weight. Researchers will test a program that combines lifestyle coaching with medication to target the body's energy regulation. The goal…

This study tests whether metformin, a common diabetes drug, can help treat depression in people living with HIV. Depression is common in this group and can make it harder to stick with HIV treatment. The trial has three parts, starting with dose testing, then a placebo comparison…

This study tests whether a chatbot can help Black adults in Minnesota quit smoking. About 120 participants will either get the chatbot or not. Researchers will see if people find it useful and if it helps them smoke less.

This study tests whether applying heat to the jaw can reduce pain and fatigue caused by teeth clenching in people with chronic temporomandibular disorder (TMD). Ten adults will clench their teeth and receive heat therapy, and researchers will track their pain levels for 8 days. T…

This early study tests a brain stimulation technique for people with long-term nerve pain that hasn't responded to other treatments. About 20 adults will receive a surgically placed device to stimulate specific brain networks. The main goal is to see if the procedure is feasible …

This study looks at how the amount of phosphorus in food affects phosphorus and calcium balance in people with moderate chronic kidney disease (CKD). Fourteen adults aged 30-75 with moderate CKD will eat either a low-phosphorus or high-phosphorus diet for 19 days each, in random …

This study looks at how cystic fibrosis medications (CFTR modulators) change in the body during pregnancy and after childbirth. Researchers will measure drug levels in the blood, breast milk, and umbilical cord blood of 30 women. The goal is to understand how these drugs behave i…

This study looks at how two medications, modafinil and d-serine, affect decision-making and brain activity in people who have had psychosis symptoms for less than five years. About 24 participants will take each drug or a placebo before playing computer brain games and having fMR…

This study looks at whether using a continuous glucose monitor and a Fitbit activity tracker can help people aged 55 and older with type 2 diabetes sit less and control their blood sugar better. Researchers will track how often participants respond to the Fitbit's 'stand' prompts…

This study uses a special dental MRI to watch how local anesthesia affects the mouth during dental procedures. About 102 adults will have their numbness and sensation measured before and after numbing shots. The goal is to better understand how dental numbing works, not to test a…

This study aims to see if a special training program can help doctors in Vietnam treat people with HIV and men who have sex with men more fairly. About 155 medical providers will take part. Researchers will measure changes in how doctors offer tests and care to see if stigma decr…

This small study tests whether a non-invasive device that stimulates the vagus nerve through the ear can affect blood sugar levels, food cravings, and the urge to move in healthy college-aged adults. Eight participants will receive the stimulation while their glucose and cravings…

This study aims to see if special MRI scans can help doctors better understand how well a transplanted kidney is working. Researchers will scan 140 kidney transplant patients to see if MRI can detect different levels of kidney function and tell the difference between normal chang…

This study looks at whether moving words to different parts of the visual field can help people with central vision loss read faster and more accurately. About 100 adults with dense blind spots in the center of their vision will take part. Researchers will measure reading speed a…

This study will use advanced MRI scans to learn more about chronic kidney disease, kidney transplants, and how kidney problems may affect the brain. Researchers will scan 180 people, including healthy volunteers and those with kidney disease, to see if MRI can help track disease …

This study aims to understand why some former smokers remain at higher risk for lung cancer years after quitting. Researchers will have 100 participants (former and never-smokers) inhale a harmless marker chemical called phenanthrene through a vape, then measure how their lungs p…