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Brain zaps timed to brain waves may boost addiction recovery

NCT ID NCT06790576

Knowledge-focused Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 02, 2026 · Updated 2 times

Summary

This study tests if timing magnetic brain stimulation to match a person's own brain waves can improve treatment for stimulant use disorder. Researchers will enroll 50 adults who are currently in treatment and have been drug-free for at least 2 weeks. Participants will get an MRI and then receive brain stimulation either randomly or timed to the peak or trough of their brain's theta waves. The goal is to see which timing method produces the best brain and behavior changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18 or older * Ability to provide consent and comply with all study procedures. * Meets Diagnostic and Statistical Manual of Mental Disorders criteria for StUD (As assessed by MINI and self-report; Participants may have current comorbid drug use, but primary diagnosis must be StUD; does not apply to healthy control participants). * At least 2 weeks of abstinence from substance use (other than caffeine or nicotine). * Intention to remain in an addiction treatment program until intervention completion (does not apply to healthy control participants). * Confident level of English language proficiency. Exclusion Criteria: * Any organic brain disorder (e.g. TBI, stroke). * Head injury resulting in skull fracture or loss of consciousness exceeding 30 minutes. * TMS contraindication (history of seizures, metallic cranial plates/screws or implanted device). * MRI contraindications (unapproved metallic implants, pacemakers or any other implanted electrical device, shrapnel, metallic braces, non-removable body piercings, pregnancy, breathing or movement disorder, claustrophobia). * Any psychotic disorder (Participants with other treated and stable psychiatric disorders will be included). * Presence of a condition that would render study measures impossible to administer or interpret. * Primary current substance use disorder diagnosis on a substance other than stimulants or cocaine, except for caffeine or nicotine. * Greater than 9 months abstinence from substance use (does not apply to healthy control participants). * Pregnancy or breastfeeding.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Stimulant use disorder

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Minnesota

    RECRUITING

    Minneapolis, Minnesota, 55414, United States

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