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New daily pill could ease knee pain and help weight loss in obesity

NCT ID NCT07153471

Symptom relief Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Sep 09, 2026 · Updated 8 times

Summary

This study tests a once-daily pill called orforglipron in 800 adults with obesity or overweight who also have painful knee osteoarthritis. The goal is to see if the drug reduces knee pain and improves physical function over about 74 weeks. Participants will be randomly assigned to receive the drug or a placebo.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 800 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

May 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a body mass index (BMI) of 27 kilograms per square meter (kg/m2) or higher at screening * Have tried at least once to lose weight through diet but were unsuccessful * Have osteoarthritis of the knee and at least one of the following conditions: * Be over 50 years old * Have morning knee stiffness that lasts about 30 minutes * Have a crackling or grinding sound or feeling in the knee Exclusion Criteria: * Have gained or lost more than 11 pounds within 90 days prior to screening * Have had a surgery for obesity or plan to have one in the next 18 months * Have an active knee infection * Have type 1 diabetes, type 2 diabetes, or any other type of diabetes * Have had a recent heart condition or New York Heart Association Functional Classification Class IV congestive heart failure * Have used any glucagon-like peptide-1 (GLP-1) receptor agonist medication within 180 days of screening

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Conditions

The condition(s) this trial relates to.

arthritic joint disease arthropathy musculoskeletal system disorder nutritional disorder Obesity obesity disorder osteoarthritis osteoarthritis, knee overnutrition

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Osteoarthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    67 sites in 5 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • ALPHA Recherche Clinique

    RECRUITING

    Québec, G3K 2P8, Canada

  • AMR Clinical

    RECRUITING

    Tempe, Arizona, 85281, United States

  • AMR Clinical

    RECRUITING

    Newton, Kansas, 67114, United States

  • AMR Clinical

    RECRUITING

    Kansas City, Missouri, 64114, United States

  • AMR Clinical

    RECRUITING

    Knoxville, Tennessee, 37909, United States

  • Activian Clinical Research

    RECRUITING

    Kingwood, Texas, 77339, United States

  • Advanced Rheumatology of Houston - Woodlands

    RECRUITING

    The Woodlands, Texas, 77382, United States

  • Aggarwal and Associates Limited

    RECRUITING

    Brampton, L6T 0G1, Canada

  • Alpha Recherche Clinique

    RECRUITING

    Québec, G2J 0C4, Canada

  • AmBeNet GmbH

    ACTIVE_NOT_RECRUITING

    Leipzig, 04107, Germany

  • Ando Orthopedic

    RECRUITING

    Kawasaki, 213-0001, Japan

  • Arizona Research Center

    RECRUITING

    Phoenix, Arizona, 85053, United States

  • Biopharma Informatic, LLC

    RECRUITING

    Houston, Texas, 77084, United States

  • Bluewater Clinical Research Group Inc.

    RECRUITING

    Sarnia, N7T 4X3, Canada

  • CDG Studienambulanz Hartard

    ACTIVE_NOT_RECRUITING

    München, 80809, Germany

  • Cardio Metabolic Institute

    RECRUITING

    Somerset, New Jersey, 08873, United States

  • Care Access - Decatur

    RECRUITING

    Decatur, Georgia, 30030, United States

  • Care Access - Huntington Beach

    RECRUITING

    Huntington Beach, California, 92648, United States

  • Care Access - Rapid City

    RECRUITING

    Rapid City, South Dakota, 57701, United States

  • Care Access - Thousand Oaks

    RECRUITING

    Thousand Oaks, California, 91360, United States

  • Carolina Research Center

    RECRUITING

    Shelby, North Carolina, 28150, United States

  • Centro Medico del Angel

    RECRUITING

    Mexicali, 21100, Mexico

  • Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C.

    RECRUITING

    Ciudad Madero, 89440, Mexico

  • Charlottesville Medical Research

    RECRUITING

    Charlottesville, Virginia, 22911, United States

  • Chase Medical Research, LLC

    RECRUITING

    Waterbury, Connecticut, 06708, United States

  • Clínica Gaias - Santiago

    ACTIVE_NOT_RECRUITING

    Santiago de Compostela, 15702, Spain

  • Clínica García Flores SC

    RECRUITING

    Monterrey, 64610, Mexico

  • Clínica nuevas Tecnologías en Diabetes y Endocrinología (NTDE)

    ACTIVE_NOT_RECRUITING

    Seville, 41003, Spain

  • Dedicated Research Site FutureMeds

    ACTIVE_NOT_RECRUITING

    Offenbach, 63065, Germany

  • Diex Recherche Inc. Division Joliette

    RECRUITING

    Joliette, J6E 6A9, Canada

  • Fukuoka Wajiro Hospital

    RECRUITING

    Fukuoka, 811-0213, Japan

  • G.R.M.O. (Groupe de recherche en maladies osseuses) Inc.

    RECRUITING

    Québec, G1V 4K5, Canada

  • Gershon Pain Specialists

    RECRUITING

    Virginia Beach, Virginia, 23454, United States

  • Goto Orthopedic Surgery Clinic

    RECRUITING

    Miyazaki, 880-0835, Japan

  • HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T

    ACTIVE_NOT_RECRUITING

    Hamburg, 20095, Germany

  • Hamanomachi Hospital

    RECRUITING

    Fukuoka, 810-8539, Japan

  • Hospital Clínico Universitario de Valladolid

    ACTIVE_NOT_RECRUITING

    Valladolid, 47010, Spain

  • Hospital Quiron Infanta Luisa

    ACTIVE_NOT_RECRUITING

    Seville, 41010, Spain

  • Hospital Quirón Málaga

    ACTIVE_NOT_RECRUITING

    Málaga, 29004, Spain

  • Hospital San Rafael - La Coruña

    ACTIVE_NOT_RECRUITING

    A Coruña, 15006, Spain

  • Hospital Universitari Vall d'Hebron

    ACTIVE_NOT_RECRUITING

    Barcelona, 08035, Spain

  • Hospital Universitario Marqués de Valdecilla

    ACTIVE_NOT_RECRUITING

    Santander, 39008, Spain

  • Huashan Hospital, Fudan University

    RECRUITING

    Shanghai, 200040, China

  • IMED Internal Medicine Clin Trials

    RECRUITING

    Monterrey, 64020, Mexico

  • Investigacion y Biomedicina de Chihuahua

    RECRUITING

    Chihuahua City, 31000, Mexico

  • Japan Community Health Care Organization - Saitama Medical Center

    RECRUITING

    Saitama, 330-0074, Japan

  • Jiangsu Province Hospital

    RECRUITING

    Nanjing, 210029, China

  • Jinan Central Hospital

    RECRUITING

    Jinan, 250013, China

  • Juno Research

    RECRUITING

    Houston, Texas, 77040, United States

  • Kariya Toyota General Hospital

    RECRUITING

    Kariya, 448-8505, Japan

  • Kato Orthopedic Clinic

    RECRUITING

    Morioka, 020-0021, Japan

  • Klinische Forschung Dresden

    ACTIVE_NOT_RECRUITING

    Dresden, 01069, Germany

  • Klinische Forschung Hamburg

    ACTIVE_NOT_RECRUITING

    Hamburg, 20253, Germany

  • Klinische Forschung Hannover-Mitte

    ACTIVE_NOT_RECRUITING

    Hanover, 30159, Germany

  • Klinische Forschung Karlsruhe

    ACTIVE_NOT_RECRUITING

    Karlsruhe, 76137, Germany

  • Kohler & Milstein Research S.A. De C.V.

    RECRUITING

    Mérida, 97070, Mexico

  • Legacy Clinical Trials

    RECRUITING

    Colorado Springs, Colorado, 80909, United States

  • Masumoto Orthopedics Clinic

    RECRUITING

    Suginami City, 167-0051, Japan

  • MedVadis Research Corporation

    RECRUITING

    Waltham, Massachusetts, 02451, United States

  • Mercy Family Clinic

    RECRUITING

    Dallas, Texas, 75208, United States

  • Nanjing First Hospital

    RECRUITING

    Nanjing, 210006, China

  • Nanjing Medical University - Nanjing Jiangning Hospital

    RECRUITING

    Nanjing, 211100, China

  • North Georgia Clinical Research

    RECRUITING

    Woodstock, Georgia, 30189, United States

  • Northwest Clinical Research Center

    RECRUITING

    Bellevue, Washington, 98007, United States

  • Northwestern University

    RECRUITING

    Chicago, Illinois, 60611, United States

  • Pingxiang People's Hospital

    RECRUITING

    Pingxiang, 337055, China

  • Private Practice - Dr. Jochen Walter

    ACTIVE_NOT_RECRUITING

    Rendsburg, 24768, Germany

  • Sapporo Maruyama Orthopedic Hospital

    RECRUITING

    Sapporo, 060-0007, Japan

  • Shimane University Hospital

    RECRUITING

    Izumo, 693-8501, Japan

  • Siteworks - Karlsruhe

    ACTIVE_NOT_RECRUITING

    Karlsruhe, 76137, Germany

  • Siteworks GmbH - Bochum

    ACTIVE_NOT_RECRUITING

    Bochum, 44787, Germany

  • Siteworks GmbH - Hannover

    ACTIVE_NOT_RECRUITING

    Hanover, 30449, Germany

  • StudyMetrix Research

    RECRUITING

    City of Saint Peters, Missouri, 63303, United States

  • Taizhou Hospital of Zhejiang Province

    RECRUITING

    Taizhou, 317000, China

  • The First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technolo -T

    RECRUITING

    Baotou, 014010, China

  • The First Affiliated Hospital of Henan University of Science &Technology

    RECRUITING

    Luoyang, 471003, China

  • The First Affiliated Hospital of Shantou University Medical College

    RECRUITING

    Shantou, 515041, China

  • The First Hospital of Qinhuangdao

    RECRUITING

    Qinhuangdao Shi, 066000, China

  • The Fourth Affiliated Hospital of Harbin Medical University

    RECRUITING

    Harbin, 150001, China

  • The Second Affiliated Hospital Chongqing Medical University

    RECRUITING

    Chongqing, 400010, China

  • The Second People's Hospital of Hefei

    RECRUITING

    Hefei, 230011, China

  • The University of Hong Kong-Shenzhen Hospital

    RECRUITING

    Shenzhen, 518053, China

  • Tokyo Saiseikai Central Hospital

    RECRUITING

    Minatoku, 108-0073, Japan

  • Universitaetsklinikum Wuerzburg

    ACTIVE_NOT_RECRUITING

    Würzburg, 97074, Germany

  • University Orthopedics Center

    RECRUITING

    Altoona, Pennsylvania, 16602, United States

  • Winterberry Research Inc.

    RECRUITING

    Stoney Creek, L8J 0B6, Canada

  • Xuanwu Hospital Capital Medical University

    RECRUITING

    Beijing, 100053, China

  • Your Research Network

    RECRUITING

    Niagara Falls, L2H 1H5, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.