OBESITY

This study tests a once-weekly injection called retatrutide to help people with obesity or overweight lose weight. About 250 adults who do not have diabetes will receive either the drug or a placebo for 65 weeks. The main goal is to see how much weight they lose and if the treatm…

This study looks at whether adding a low dose of the diabetes medication insulin detemir to a low-calorie diet helps people with obesity and type 2 diabetes lose more weight and improve brain function related to food reward. 240 adults aged 31-60 will be randomly assigned to eith…

This study planned to test a dietary supplement called WM Formula for weight loss in adults with obesity. Researchers wanted to see if it helped with weight, blood sugar, and gut health. However, the study was withdrawn before any participants were enrolled, so no results are ava…

This study looks at whether combining high-intensity interval training, recovery in low-oxygen conditions, and taurine supplements can improve health in women with obesity. Researchers will measure body composition, blood fats, inflammation, and muscle cell function. The goal is …

This study looks at whether endoscopic sleeve gastroplasty (ESG), a procedure that makes the stomach smaller using a flexible tube through the mouth, can improve liver health in 20 adults with obesity and advanced NASH (a severe fatty liver disease with scarring). Researchers wil…

This study compares two weight-loss surgeries—standard duodenal switch and a newer version called SADI—in 56 adults with severe obesity (BMI over 45). Researchers track weight loss, health problems like diabetes and high blood pressure, and risks like malnutrition. The goal is to…

This study tests an investigational drug called taldefgrobep alfa to help adults with overweight or obesity lose weight. About 150 participants receive either the drug or a placebo injection weekly for 24 weeks, with an option to continue in an open-label extension. The main goal…

This study tests a new weight-loss medicine called survodutide in over 5,500 adults with obesity or overweight who also have heart or kidney disease or related health problems. Participants receive weekly injections of survodutide or a placebo for up to 2 years and 3 months, alon…

This study looks at two different ways to use weight loss medications over 21 months in 150 adults with obesity. Participants first take a weekly injection (tirzepatide or semaglutide) for 9 months, then switch to a daily pill (either phentermine-topiramate/naltrexone-bupropion o…

This large Phase 3 trial tests a once-daily tablet called orforglipron against a placebo in 1,200 adults who are obese or overweight, some of whom also have type 2 diabetes. The study is split into two parts: one for people without diabetes and one for those with diabetes. The go…

This early study tests a new, non-surgical procedure called endoscopic Gastric Mucosal Ablation (GMA) for weight loss in 15 people with obesity. The procedure uses a tool to treat the stomach lining, aiming to mimic some effects of weight loss surgery without incisions. The main …

This study was designed to test the safety of an experimental drug called garetosmab in healthy men and postmenopausal women with obesity. Researchers planned to measure side effects, drug levels in the blood, and effects on hormones and blood clotting. However, the study was wit…

This study tests whether a probiotic called Limosilactobacillus fermentum CRL 1446 can improve health in 80 adults with heart disease risk factors like obesity, high blood pressure, and high cholesterol. Participants take either the probiotic or a placebo daily, and researchers m…

This study tests a daily injection called setmelanotide in 18 people aged 6 to 65 with Prader-Willi syndrome, a condition causing severe obesity and constant hunger. The goal is to see if the drug safely reduces body weight and controls appetite over 52 weeks. Participants must h…

This study tests a new tablet called VCT220 to help overweight or obese adults lose weight. About 840 participants will take either a high dose, low dose, or a placebo pill once daily for 12 months. The main goal is to see how much weight they lose and if they achieve at least a …

This study tests a new once-weekly injection called MET097 to help people with obesity or overweight lose weight. About 225 adults will receive either MET097 or a placebo for 28 weeks. The main goal is to see how much weight they lose compared to those on placebo.

This study tests a program called TOTAL that uses an educational video and motivational coaching sessions over video calls to help veterans with obesity start and stick with proven treatments like the MOVE! weight management program, weight loss medications, or bariatric surgery.…

This study tests whether tirzepatide, a GLP-1 drug, can help people with severe obesity lose more weight a year after gastric bypass surgery. About 30 adults will either take the drug or continue standard care. Researchers will track weight, body fat, and side effects to see if t…

This study planned to help toddlers with obesity by improving what they eat. Parents would join a free online nutrition program and could also take weight-loss medication. The idea was that helping parents eat better would also improve their toddler's diet and weight. However, th…

This study tests a special low-calorie, high-protein tube feeding formula in 12 obese adults who rely on tube feeding for most of their nutrition. The goal is to see if it helps them lose weight while keeping muscle mass and improving blood pressure, blood sugar, and cholesterol.…

This study tests a new weekly injection called IBI362 against the existing drug semaglutide in 349 Chinese adults with early type 2 diabetes and obesity. The goal is to see if IBI362 is better at lowering blood sugar and helping people lose weight. Participants will receive eithe…

This study tests whether adding trevogrumab (with or without garetosmab) to the weight-loss drug semaglutide (Wegovy) helps people with obesity lose more fat while preserving muscle. About 1005 participants will be enrolled across three parts, including healthy volunteers and peo…

This study tests a new magnetic system (MagDI) that creates a connection in the small intestine to help with weight loss and type 2 diabetes. About 60 adults with obesity (BMI 30-50) and either diabetes or weight regain after previous surgery will be enrolled. The goal is to see …

This study tests a new medicine called survodutide to see if it helps people with obesity burn more energy and fat. About 64 adults aged 18 to 65 with a BMI between 30 and 45 will take part. They will receive either survodutide or the existing drug semaglutide once a week for sev…

This study tests a smartphone app that uses artificial intelligence to predict and prevent unhealthy eating, combined with a continuous glucose monitor. The goal is to help 300 adults with overweight or obesity improve their eating habits and lose weight. Participants will use th…

This study looks at whether phentermine, a weight-loss drug approved for short-term use, can be taken safely for up to 2 years to help manage obesity. About 870 adults with obesity or overweight plus related health issues will take the drug and be monitored for weight loss, blood…

This study aimed to see if the weight-loss drug Wegovy (semaglutide) could help active-duty military personnel with obesity lose weight and improve their fitness. It planned to follow participants for 24 weeks on the drug and then 52 weeks off it. However, the study was withdrawn…

This study tests whether virtual group visits can help adults with type 2 diabetes and related heart conditions better manage their health. About 720 participants will join online group sessions led by healthcare providers. The main goal is to see if these visits lower blood suga…

This study looks at how two popular weight-loss medications, semaglutide and tirzepatide, change the way the stomach empties food. Thirty adults with obesity or overweight will receive weekly shots of either drug or a placebo for 24 weeks. Researchers will measure stomach emptyin…

This study compares an intensive weight loss program—including meal replacements, counseling, and weight-loss medication—to standard care for adults with obesity. About 480 participants aged 18 to 60 with a BMI of 30 or higher (or lower for certain ethnic groups) are involved. Th…

This study tests two drugs, LY3841136 and tirzepatide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 350 people will take part for 64 weeks. The goal is to see if these treatments are safe and effective for chronic weight mana…

This study was designed to see if adding an experimental drug called ofirnoflast to the standard diabetes medication semaglutide helps obese or overweight adults with type 2 diabetes control their blood sugar and lose more weight. The trial planned to compare the combination agai…

This study tests a procedure that reroutes part of the small intestine to help control blood sugar in people with type 2 diabetes and obesity. About 15 participants with a BMI between 30 and 50 will be followed for a year to see if their HbA1c levels improve. The goal is better d…

This study looks at whether adding stress management techniques to a standard weight loss program helps Black women with obesity lose more weight. About 341 women with high stress levels will take part. The goal is to see if a culturally-tailored approach improves weight loss res…

This study tests a smartphone app that helps people with obesity stay on track with their diet during a 3-month online weight loss program. About 200 adults with obesity and heart disease risk factors will use the app, which sends surveys and offers tips when it detects a risk of…

This study tests different doses of the investigational drug tirzepatide in people with type 2 diabetes and obesity who already take metformin. The main goal is to see how much weight participants lose and how their blood sugar control improves. About 414 adults will take part fo…

This study tests a new drug called MET097 to help people with obesity or overweight lose weight. Participants receive weekly injections for 12 weeks, then switch to monthly doses for up to 64 weeks. The goal is to see if the drug is safe and effective compared to a placebo. About…

This study compares a new esophageal stent (Luso-Cor) with standard stents and vacuum therapy for closing leaks that can happen after weight-loss or cancer surgery on the stomach or esophagus. About 180 adults who develop these leaks will be enrolled. The goal is to see which met…

This study tests a new drug called nimacimab, given as a weekly injection, to see if it helps people who are overweight or obese lose weight. Some participants will receive nimacimab alone, some with another weight-loss drug (semaglutide), and some a placebo. The trial involves 1…

This study tests a once-weekly medicine called retatrutide in about 1000 adults with type 2 diabetes who are overweight or have obesity. The goal is to see if it helps with weight loss and, for a subset with sleep apnea, improves breathing during sleep. Participants receive eithe…

This study tests an online version of a treatment program called Step by Step for people with obesity. The program includes six group meetings over 6-8 months to teach about obesity, support lifestyle changes, and reduce stigma. The goal is to see if it improves quality of life a…

This study tests a new weekly pill, VRB-101, to help people with obesity or overweight who also have weight-related health problems lose weight. About 206 participants will receive either the drug or a placebo. The main goal is to see how much weight they lose over the treatment …

This study looks at whether giving people with obesity and diabetes a monthly $160 subsidy for fruits and vegetables helps them buy more healthy food. 214 adults will be split into groups, some getting the subsidy and some not, for 3 months. Researchers will track how much produc…

This study tests whether gamification—using game-like elements and social rewards—can help overweight veterans with high blood pressure become more physically active. About 725 veterans will take part in a 9-month program where they either compete or cooperate to increase their d…

This study tests a new weekly injection called petrelintide in 221 adults who are overweight or obese and have type 2 diabetes. The goal is to see if it helps with weight loss and blood sugar control compared to a placebo. Participants must be on stable diabetes medication like m…

This study tests an oral medication called orforglipron, taken once daily, to help adults with obesity or overweight who also have weight-related conditions like high blood pressure or sleep apnea. About 3,100 participants will receive either the drug or a placebo for 72 weeks, w…

This study tests a weekly medicine called tirzepatide in adults with type 1 diabetes who are also overweight or have obesity. The goal is to see if it helps control blood sugar and reduce weight better than a placebo. About 465 people will take part for around 20 months, and all …

This study tests a new, non-surgical weight loss method called Gastric Mucosal Ablation (GMA) for people with class III obesity (BMI over 40). Instead of surgery, doctors use a thin tube and a special device to treat the stomach lining. The main goal is to check if the procedure …

This study tests whether a weekly injection of semaglutide can help 500 adolescents with obesity lose weight and keep it off for at least 3 years. All participants receive the medicine, which is injected into the stomach, thigh, or upper arm. The goal is to see if the treatment c…

This study tests a new drug called HM15275 to help people with obesity lose weight. It involves 267 adults who are obese or overweight but do not have diabetes. Participants receive either the drug or a placebo for 36 weeks to see how much weight they lose and if the drug is safe…

This study tests a once-weekly injection called CagriSema (a mix of two medicines) to help people with obesity or overweight lose weight. About 3,400 adults will receive either CagriSema, one of its components, or a placebo for 1.5 years, followed by a 2-year extension to see if …

This study tests whether adding a weight-loss drug (tirzepatide) to a standard psoriasis medication (ixekizumab) helps people with moderate-to-severe psoriasis and obesity or overweight lose weight while clearing their skin. About 250 adults will receive either ixekizumab alone o…

This early-stage study tests a new drug called BMF-650 in 80 healthy adults who are overweight or obese. The main goal is to check if the drug is safe and how the body processes it. Participants receive either the drug or a placebo, and researchers monitor side effects and vital …

This study looks at how well the weight-loss drug Wegovy works for Korean adults with obesity in everyday doctor visits. About 500 people will take the weekly shot as prescribed, and researchers will track weight changes and safety over 52 weeks. The goal is to see real-world res…

This study tests whether a natural substance called spermidine can improve heart and muscle health in people aged 65 and older with coronary artery disease. Participants take spermidine or a placebo for a period, and researchers measure changes in heart mass, muscle mass, inflamm…

This study tests whether adding an experimental drug (RO7204239) to an existing weight-loss medication (tirzepatide) helps people with obesity or overweight lose more weight over 48 weeks. About 285 adults who have at least one weight-related health issue (like high blood pressur…

This study tests a new magnetic device that creates a shortcut in the intestines to help people with obesity and type 2 diabetes lose weight and control blood sugar. Ten adults aged 18-65 with a BMI of 30-35 and diabetes will receive the device. The goal is to see if the procedur…

This study tests whether giving people free boxes of fruits and vegetables along with nutrition tips can help manage conditions like diabetes, high blood pressure, and obesity. About 300 adults from three Mississippi counties with high poverty and health disparities will take par…

This study tests a new drug called XW003 against an existing weight-loss drug, semaglutide, in 163 Chinese adults with obesity. Participants must have a BMI of 30 or higher and a large waist size. The main goal is to see how much weight they lose and how safe the drugs are. This …

This study tests a special magnet system that creates a new connection between the stomach and intestine without traditional surgery. The goal is to help adults with obesity and type 2 diabetes lose weight and control blood sugar. About 35 participants will be enrolled to see if …

This study looks at whether adding kefir, a fermented milk drink, to the diet of obese children can help lower their body mass index (BMI) and improve related health problems like insulin resistance and fatty liver. About 60 children with a BMI above the 95th percentile will take…

This study tests a once-weekly injection called retatrutide for weight loss in people with obesity or overweight who do not have diabetes. About 2,335 participants will receive the drug or a placebo for up to 89 weeks. The study also looks at how the drug affects knee osteoarthri…

This study looks at how well the Joslin Why WAIT? program works for people with type 2 diabetes and a BMI over 35. The program focuses on weight loss and intensive treatment to improve health. Researchers are measuring weight loss, blood sugar control, and cholesterol levels in 1…

This study tests a new magnetic system that creates a connection in the small intestine to help with weight loss and type 2 diabetes. It involves 25 adults with obesity and diabetes who have not had success with other treatments. The goal is to see if the procedure is safe and wo…

This study tests whether a game-like mobile app, combined with brain-training games, can help overweight men lose weight and keep it off. About 228 men will use either a standard weight-loss app or a gamified version with team challenges and rewards. The goal is to see if making …

This study tests if semaglutide, a drug used for diabetes, can reduce harmful belly fat and improve heart health in people with HIV who have extra belly fat. About 108 participants will receive either the drug or a placebo for 32 weeks. The goal is to see if the drug can lower fa…

This study tests a once-daily pill called orforglipron against a placebo in 600 adults with obesity or overweight who also have type 2 diabetes. The goal is to see if the pill helps lower blood sugar and body weight over about 18 months. Participants must have a BMI of 25 or high…

This study tests a new medicine called CagriSema (a mix of two drugs) for weight loss in 400 adults with severe obesity (BMI 35 or higher). Participants receive either CagriSema or a placebo for 2 years, then an extra year where some switch to CagriSema or reduce their dose. The …

This study is testing whether Contrave, a prescription weight-loss medication, increases the risk of serious heart problems like heart attacks, strokes, or heart-related death. About 8,600 obese or overweight adults with heart risk factors are taking either the drug or a placebo.…

This study tests if tirzepatide, a once-weekly injection, is safe and effective for adults with type 1 diabetes who are overweight or have obesity. About 905 participants will receive either tirzepatide or a placebo for 49 weeks. The main goals are to see if it improves blood sug…

This early-stage study tests the safety of an experimental drug called LY3537031 in 302 people who are overweight, obese, or healthy. Researchers will monitor side effects, measure how the drug moves through the body, and track weight changes over about 49 weeks. The goal is to s…

This study looks at whether a new digital weight-management program can help people with obesity lose weight and improve their quality of life. About 580 adults referred to NHS weight-loss services will use the program for 12 months. Researchers will measure weight change, cost-e…

This study compares two approaches to help rural adults with obesity lose weight. One group meets one-on-one with their doctor every three months. The other joins a group lifestyle program over Zoom plus quarterly team meetings with their doctor and a lifestyle coach. Researchers…

This study compares a diet focused on fiber to standard weight loss advice in 63 adults with obesity. Researchers want to see if fiber improves eating behavior, weight, and health markers. Participants must be 18-65, have a BMI of 30 or higher, and eat 25 grams or less of fiber d…

This study tests an experimental medicine called cagrilintide to help people with overweight or obesity and type 2 diabetes lose weight. About 330 adults will receive either cagrilintide or a placebo for around 18 months. The main goals are to see how much weight they lose and ho…

This study tests a new medicine, cagrilintide, to help people with obesity or overweight lose weight. About 300 adults will receive either the drug or a placebo for around 18 months. The main goals are to see how much weight they lose and how many achieve at least a 5% reduction.…

This study tests a new, remotely delivered weight-loss program (EVO) against the current gold-standard Diabetes Prevention Program (DPP) in adults with obesity (BMI 30-45). Over 500 participants will use a smartphone app and video calls to lose weight. The goal is to see which pr…

This study aimed to test two drugs, bimagrumab and tirzepatide, alone or together, for helping adults with obesity or overweight and type 2 diabetes lose weight. Participants would have taken injections for about 13 months. However, the study was withdrawn before enrolling anyone…

This study tests a new once-weekly medicine called NNC0662-0419 in 224 adults with overweight or obesity. Participants receive either the active drug or a placebo to see if it is safe and helps with weight loss. The main goals are to check for side effects and measure changes in …

This study tests a new drug called IBI362 in Chinese adults aged 18-55 with moderate to severe obesity (BMI 32.5 or higher). The goal is to see if the drug is safe, what side effects it may cause, and how the body processes it. Participants receive either IBI362, a placebo, or an…

This study tests an experimental drug called AZD6234 to see if it helps people with overweight or obesity and type 2 diabetes lose more weight when added to their current diabetes medication. About 69 adults will receive either AZD6234 or a placebo for 26 weeks. The main goal is …

This pilot study tests whether a 6-month low-carbohydrate diet can improve blood sugar control and body composition in 40 obese adults, some with prediabetes or diabetes. Participants will also be monitored for changes in gut-brain communication. The goal is to understand how die…

This study follows about 1,000 people with obesity in Japan who are taking Wegovy as part of their normal care. Researchers will track side effects and weight changes over 2 years to see how the drug works in everyday life. The goal is to better understand the drug's safety and e…

This large phase 3 study is testing whether tirzepatide, a medication for weight management, can reduce the risk of serious health events like heart attacks, strokes, and death in over 15,000 adults with obesity or overweight. Participants either have existing heart disease or ar…

This study tests whether two drugs, bimagrumab and tirzepatide, work better together than alone for weight loss in adults with obesity or overweight who do not have type 2 diabetes. About 240 participants will take the drugs or a placebo for 70 weeks. The main goal is to see how …

This study tests a new drug called HRS9531 against a standard weight-loss drug, semaglutide, in adults with obesity. About 572 people will receive weekly injections for 52 weeks to see which drug leads to more weight loss and better health measures like waist size. The goal is to…

This study tests a year-long program that teaches cooking, nutrition, mindfulness, and exercise to adults with obesity. The goal is to see if learning these skills can lead to better eating habits, weight loss, and improved lab results like blood sugar and cholesterol. About 320 …

This study tests a once-weekly injection called CagriSema (a combination of two medicines) for weight loss and long-term weight maintenance in adults with obesity. About 600 participants will receive either CagriSema or a placebo for up to 3 years. The goal is to see how much wei…

This study compares two types of weight-loss surgery (standard bypass vs. a simpler single-loop bypass) in people who have already had a partial stomach removal (parietal gastrectomy) but still have obesity or have regained weight. The goal is to see if the simpler surgery causes…

This study tests a procedure called Revita DMR, which uses heat to treat the lining of the upper gut, to help people with obesity keep weight off after they stop taking the weight-loss drug tirzepatide. About 315 adults who lost at least 15% of their body weight on tirzepatide wi…

This study tests whether a daily injection of liraglutide (3.0 mg) helps children aged 6 to 12 with obesity lose weight. About 78 children will receive either the drug or a placebo for 56 weeks, along with healthy eating and exercise advice. The main goal is to see how much their…

This study tests whether a new drug, retatrutide, works better than the existing drug tirzepatide for weight loss in adults with obesity. About 800 participants will receive either drug for 89 weeks. The main goal is to see how much body weight they lose and check for side effect…

This study tests whether the drug retatrutide can help people with obesity maintain weight loss over time. About 643 participants will first take the drug for 80 weeks, then some will switch to placebo while others continue the drug for another 36 weeks. The goal is to see if ret…

This study follows 1,250 people with obesity who are starting Wegovy as part of their regular medical care. Researchers will track changes in weight, waist size, and quality of life over two years to see how the drug works in everyday life. The goal is to understand real-world ef…

This study tests whether teaching kidney transplant recipients to eat a whole-food plant-based diet can improve their blood pressure, blood sugar, and weight, and reduce hospital visits. About 49 adults who had a kidney transplant in the past year and have high blood pressure, hi…

This study was designed to test a new combination of two drugs (sibutramine and topiramate) for helping overweight adults with conditions like high blood pressure or diabetes lose weight. It was a large, carefully controlled trial that planned to compare the new drug against a pl…

This study tests a once-daily tablet called orforglipron to see if it helps people with obesity or overweight lose weight. About 600 adults who do not have diabetes will take either the drug or a placebo for around 18 months. The main goal is to measure how much weight they lose …

This study tests a weight management program for Mexican American women that adds relationship skills counseling for mothers and adult daughters. The goal is to improve family communication and teamwork around eating and exercise to support long-term weight control. About 236 wom…

This early-stage study tests whether the drug RO7204239 can improve how the body uses insulin in people with type 2 diabetes who are also overweight or obese. About 30 participants will receive either the drug or a placebo for 24 weeks. The main goal is to measure changes in insu…

This early-phase study tests a single injection of HRS-5817 in 40 obese adults aged 18-55 with a BMI of 30-40. The main goal is to check safety and side effects, not to cure obesity. Researchers will also measure how the drug moves through the body and how the immune system respo…

This study tests a new medication called aleniglipron in adults with type 2 diabetes who are also overweight or have obesity. The main goal is to check if the drug is safe and tolerable at different doses. Researchers will also measure changes in body weight and blood sugar level…

This study tests a new drug called maridebart cafraglutide to help adults with obesity or overweight lose weight. About 3853 people took the drug or a placebo for 72 weeks. The main goal is to see how much weight they lose and if it is safe.

This study tests a drug called setmelanotide in people aged 6 to 65 with obesity linked to specific gene variants (POMC, PCSK1, LEPR, SRC1, or SH2B1). Participants are randomly assigned to receive the drug or a placebo to see if it helps reduce body weight and BMI. The goal is to…

This study tests whether tirzepatide, a medication for weight and diabetes management, can improve kidney health in 140 adults with overweight or obesity and chronic kidney disease (with or without type 2 diabetes). Researchers will use MRI scans to measure changes in kidney fat …

This study aimed to see if using an exercise phone app and a continuous glucose monitor could help teenagers with obesity, prediabetes, or type 2 diabetes lose weight and improve their health. Participants would have worn a glucose sensor and used the app with coaching support. H…

This study tests whether a combination of two drugs, phentermine and topiramate, can help teens aged 12 to 18 with severe obesity maintain weight loss after a meal replacement program. The body often fights weight loss by increasing appetite and slowing metabolism, making it hard…

This study tests whether a weekly injection of semaglutide helps children aged 6 to 17 with obesity or overweight lose weight. About 210 kids will receive either the drug or a placebo, plus lifestyle advice. The study lasts about 2.5 years and focuses on safety and long-term weig…

This study looks at whether limiting eating to a 10-hour period each day can help people with obesity lose weight and reduce body fat. About 61 adults who typically eat over 14 hours daily will either get standard nutrition advice or combine that advice with a 10-hour eating wind…

This study tests whether guiding people to use free online weight loss tools helps them lose weight. About 473 adults with obesity or overweight plus related health issues will take part. Half will get a 52-week program with support, and the other half will receive educational ma…

This study aimed to see if a virtual weight control program (WW) could lower blood sugar levels in adults with type 2 diabetes and obesity. It planned to enroll about 0 participants aged 18-74 with high blood sugar and overweight. However, the study was withdrawn before any parti…

This study tests whether adding an experimental drug (NT-0796) to semaglutide (a weight-loss medication), along with diet and exercise, helps people with obesity lose more weight and reduce inflammation. About 82 adults with a BMI of 30 or higher will receive either the combinati…

This study compares two versions of a procedure called Transoral Outlet Reduction (TORe) for people who regained weight after Roux-en-Y gastric bypass. About 70 adults will be randomly assigned to one of the two methods. Researchers will track weight loss, safety, and success rat…

This study compares a very-low-calorie ketogenic diet (VLCKD) to a standard Mediterranean diet in 100 adults with severe obesity and metabolic syndrome. Researchers will track weight, blood sugar, cholesterol, blood pressure, and artery health over 36 months to see which diet lea…

This study tests a video-based healthy lifestyle program for adults aged 50 to 74 who are overweight and have conditions like prediabetes, diabetes, or high blood pressure. Participants use a tablet and fitness tracker at home, and some get extra support from a coach by video or …

This study is testing whether two markers in the blood, PLIN2 and RAB14, can accurately diagnose non-alcoholic steatohepatitis (NASH) and advanced liver scarring. Researchers will analyze blood samples from 828 people with NASH, type 2 diabetes, or obesity. If successful, this ap…

This study tests a mobile health program to help young Air Force personnel prevent weight gain over two years. About 350 active-duty members aged 18-39 with a BMI of 21-30 will use a Fitbit and a smartphone app to track their weight and activity. The goal is to see if this approa…

This study tests whether a family-focused lifestyle program can lower type 2 diabetes risk and improve quality of life in high-risk Latino families. About 132 Latino children aged 10-16 with obesity will take part. The program focuses on healthy eating and physical activity to pr…

This study tests whether a mobile app for parents can help prevent overweight and obesity in school children aged 5-11 in Mexico City. About 743 children from four schools will take part, with some families using the app and others not. The app gives tips on healthy eating and ph…

This study compares time-restricted eating (eating only during a set daily window) to traditional calorie counting for weight loss and reducing colorectal cancer risk. About 193 adults with obesity, aged 45-70, will follow one of the two diets for a period. The goal is to see if …

This study tests a program called 'Healthy Dads, Healthy Kids' adapted for Hispanic families. It aims to help fathers lose weight and increase their children's physical activity to prevent obesity. About 187 fathers and their children (ages 5-11) from the Houston area are taking …

This study tests a family program called Turtle Island Tales for American Indian families living in poverty. The program aims to prevent obesity and cancer by encouraging healthy eating, physical activity, less screen time, and better sleep. About 200 caregivers with children age…

This study aims to prevent childhood obesity by promoting healthy eating and physical activity in disadvantaged urban communities across six countries. About 36,000 children aged 6-13 will take part in programs designed to improve their diet, exercise habits, and quality of life.…

This study tests a personalized program to help Hispanic/Latino families with young children (ages 4-6) prevent obesity. The program is designed to overcome everyday barriers to healthy eating and activity. About 301 parent-child pairs will take part, and researchers will track c…

This study tests if encouraging water instead of sugary drinks at childcare centers can help prevent obesity in preschool-aged children. Researchers will track 882 kids' drink choices and weight changes over time. The goal is to see if this simple change early in life can make a …

This study is testing a digital health platform called STELA that helps adults without heart disease lower their risk factors like obesity, high cholesterol, and insulin resistance. About 100 participants will get a full health check, a personalized prevention plan, and support t…

This pilot study looks at whether adding hunger training to a standard diabetes prevention program helps obese women at high risk for breast cancer lose weight and potentially lower their cancer risk. About 51 participants will learn weight-loss strategies and how to recognize tr…

This study looks at whether making dietary guidelines more culturally relevant can help African American adults eat healthier and lower their risk for type 2 diabetes. About 198 participants will be randomly assigned to one of three eating patterns: a standard healthy U.S. diet, …

This study looks at whether a community-based diet and exercise program for pregnant women can lower the chances of obesity and diabetes for both mothers and their children. About 1,000 pregnant women in urban areas will take part during and after pregnancy. The goal is to see if…

This study tests a program designed to help new bus operators avoid weight gain and adjust to their jobs. About 284 new hires from several transit authorities will take part for two years. Some will receive the special program, while others will follow usual work practices. The g…

This study tests whether a personalized nutrition plan can help people with traumatic spinal cord injury avoid gaining excess body fat and becoming obese during the first year after injury. The trial involves 56 participants with spinal cord injuries between levels C1 and L2. Res…

This small pilot study tests whether taking oral probiotics for 12 weeks can improve asthma control and insulin resistance in obese adults with asthma. Researchers will measure changes in gut and airway bacteria, inflammation, and breathing tests. Only 7 participants are enrolled…

This pilot study is testing a new exercise-focused group for people who are overweight or have obesity. The goal is to see if the group helps increase physical activity without raising the risk of unhealthy eating behaviors. The study will enroll 12 adults who have had weight los…

This pilot study tests whether an 8-week program combining mindful eating and gentle yoga is practical and well-liked by adults with overweight or obesity. Researchers will see if the program improves mindfulness, eating habits, physical activity, and body measurements. Participa…

This study planned to compare a new type of airway device with a standard one to see if it could prevent dangerously low oxygen levels during anesthesia. It was designed for adults at high risk, such as those with obesity or sleep apnea. However, the study was withdrawn before an…

This early-stage study tests a new injectable medicine for people who are overweight or have obesity. The main goal is to check if the medicine is safe and how the body handles it. About 63 participants will receive either the study drug or a placebo. This is a phase 1 trial, so …

This study looks at how losing weight through either bariatric surgery or a standard diet program affects sexual function and sperm quality in men with severe obesity. About 59 men with a BMI over 25 will take part. The goal is to see which approach leads to better sexual health …

This study tests whether adding online weight loss classes to standard cardiac rehab helps people with atrial fibrillation (AFib) and obesity lose at least 10% of their body weight and feel better. About 120 adults with AFib and a BMI of 30 or higher will take part. The goal is t…

This study tests a non-invasive device that sends mild electrical pulses to a nerve in the ear (the vagus nerve) to help people with obesity lose weight and feel better. About 131 adults with mild to moderate obesity will use the device and be tracked for changes in body fat, BMI…

This study looks at whether adding online yoga classes to an internet-based weight loss program helps people with obesity lose more weight. About 210 adults with a BMI between 25 and 40 will take part. After 3 months of weight loss treatment, they are randomly assigned to either …

This pilot study looks at how the weekly medication tirzepatide affects body composition, bone density, and physical abilities in 40 older adults with obesity over nine months. Participants take the drug, track their diet and activity, and attend regular check-ins. The goal is to…

This study compares two types of weight-loss surgery—sleeve gastrectomy alone versus sleeve gastrectomy with transit bipartition—to see which leads to fewer digestive issues (dumping syndrome) and better quality of life. About 200 adults with obesity will be followed for 6 months…

This study tests whether virtual reality exposure therapy can improve how people feel about their body after bariatric surgery. It involves 11 patients who are 18 to 30 months past surgery and unhappy with their body image. Participants use VR to address body concerns, and result…

This study tests whether aggressive weight loss using semaglutide can improve symptoms in people with obesity-related heart failure with preserved ejection fraction (HFpEF). About 81 participants will receive either semaglutide or a placebo, and researchers will measure heart pre…

This study looks at whether adding a small bypass (gastroenteroanastomosis, or GEA) to vertical sleeve gastrectomy (VSG) can lower the chance of acid reflux after surgery. About 60 adults with obesity will be split into two groups: one gets VSG with GEA, the other gets VSG alone.…

This study tests whether an 8-session nutrition education program is practical and well-liked by patients in a general medicine clinic. The program focuses on eating more fiber-rich foods like fruits, vegetables, and whole grains. It includes 42 adults with prediabetes, diabetes,…

This study tests whether high doses of vitamin D3 can improve asthma control and reduce severe attacks in adolescents aged 12-17 who have obesity, asthma, and low vitamin D levels. Participants receive either a single high dose plus daily supplements or a lower daily dose for thr…

This study looks at whether exercising once a week or three times a week is better for reducing liver fat in adults with non-alcoholic fatty liver disease (NAFLD) and central obesity. 300 participants will follow exercise programs that match World Health Organization guidelines. …

This study tests whether a daily mulberry extract called Reducose can lower blood sugar and insulin spikes after meals in obese children and teens. Researchers will measure changes in glucose and insulin levels during a sugar-drink test, along with weight and BMI, over 12 weeks. …

This study was designed to learn how body weight changes the way etanercept works in obese adults and children with arthritis. Researchers planned to measure drug levels and disease activity scores. The study was withdrawn before enrolling any participants, so no results are avai…

This study looks at how obesity may cause fertility problems by disrupting hormones and metabolism. Researchers will measure hormone levels and insulin response in 84 women with a healthy weight. The goal is to understand the link between obesity and infertility to guide future t…

This early-stage study compares how two different injection versions of the experimental drug maridebart cafraglutide are absorbed by the body. About 348 adults with overweight or obesity will receive a single dose of one version. The main goal is to measure drug levels in the bl…

This observational study follows 728 pregnant women who took Wegovy for weight management and compares their babies' health to those not exposed. Researchers will track birth defects and infant development through the first year of life. The goal is to understand if Wegovy poses …

This study looks at why some people store fat around their belly (apple shape) while others store it around their hips and thighs (pear shape). Researchers will take small fat samples from 27 healthy adults and study the epigenetic marks—chemical tags that control how genes work—…

This study aimed to see if exercising in the morning versus the evening changes how the body handles sugar in adults with prediabetes. Participants would have completed short exercise sessions at different times, with their blood sugar and sleep tracked. However, the study was wi…

This study was designed to test whether a fasting-mimicking diet (a low-calorie, high-unsaturated-fat diet) could activate beige/brown adipose tissue (BAT) — a type of body fat that burns calories — in adults with overweight. The researchers planned to measure BAT activity using …

This study looks at how emotions, attachment, and feeding work together in mothers and babies during the first year of life. Researchers want to understand why some babies gain weight quickly, which can lead to obesity later. About 250 mother-infant pairs will be observed to see …

This study looks at how giving glucagon (a hormone) for 72 hours changes the amount of energy the body uses in healthy, non-diabetic adults with obesity. Researchers compare glucagon to a placebo to see if it boosts energy expenditure. The goal is to learn more about how glucagon…

This study looks at how immune cells in different types of body fat (belly fat vs. fat under the skin) are linked to insulin resistance and weight loss. Researchers will analyze fat samples from 50 people having weight-loss surgery. The goal is to understand why some people with …

This study looks at how amino acids change the release of glucagon and insulin compared to glucose alone. Researchers will test 30 people who are healthy, have type 2 diabetes, or are obese. The goal is to better understand hormone regulation in these conditions.

This study follows about 3,000 adults in Port-au-Prince, Haiti, for up to 7 years to learn how common heart disease risk factors like high blood pressure, diabetes, and smoking are, and how they lead to heart attacks, strokes, and other problems. Participants give blood, stool, a…

This study looks at whether regular endurance exercise during breastfeeding changes the makeup of breastmilk in mothers who are overweight or have obesity. Researchers will also check if any changes affect the baby's growth and health. About 62 mothers and their infants are takin…

This study uses insurance records to compare health outcomes for mothers and babies when Wegovy is taken during pregnancy versus when it is not. Researchers will look at birth defects and other issues in about 1,139 women aged 15-45. The goal is to help patients and doctors make …

This early-stage study looks at how a single dose of an experimental medicine (PF-08653944) is absorbed when injected into the abdomen, thigh, or upper arm. It involves 54 overweight or obese adults who are otherwise healthy. The goal is to understand safety and how the body proc…

This study looks at why people on a weight loss program sometimes break their diet rules. Researchers will use smartphone surveys and wrist sensors to track eating, activity, and mood in 150 adults over 18 months. The goal is to find patterns in diet slip-ups so future treatments…

This study looks at how often acid reflux (GERD) happens in people with obesity after they have a weight-loss procedure, either surgery or an endoscopic treatment. Researchers will track 250 adults over time to see who develops reflux symptoms, silent reflux, or related complicat…

This early-stage study checks whether maridebart cafraglutide, a drug for overweight or obesity, changes the heart's electrical activity. About 81 adults aged 18-60 will receive the drug, a placebo, or a positive control to compare effects. The main goal is to see if the drug cau…

This study looks at how amino acids (building blocks of protein) trigger the liver to release certain hormones, and why this process may be different in people with fatty liver disease. Researchers will give amino acid infusions to 30 healthy volunteers and patients with fatty li…

This study follows over 5,000 Black and White adults from age 18-30 for decades to see how their lifestyle and health changes affect heart disease risk later in life. Researchers measure things like blood pressure, weight, and cholesterol over time. The goal is to understand what…

This study looks at how exercise affects signals from muscles that help burn fat. Researchers will compare obese, lean, and athletic adults aged 18-40. They measure muscle energy use and proteins in blood and tissue samples. No treatment is given; the goal is to learn more about …

This early-stage study looks at how a new drug called RAY1225 interacts with four common medicines (warfarin, atorvastatin, metformin, and digoxin) in 32 healthy adults. The goal is to measure drug levels in the blood and check for side effects when taken together. This helps ens…

This study was designed to see if changing when you eat affects natural body chemicals linked to pleasure eating and metabolism. Researchers planned to measure hunger, blood sugar, and weight changes in healthy adults. However, the study was withdrawn before any participants were…

This study gathers information from about 2,500 adults in Australia, Germany, UAE, and Spain who have been prescribed injectable semaglutide for weight management. Participants complete online surveys about their health, weight changes, and quality of life. No new treatment or la…

This study looks at how iron levels in the brain, gut bacteria, and blood sugar are connected to thinking and memory in people with obesity. Researchers will track 138 adults aged 30-65 using brain scans, glucose monitors, sleep trackers, and cognitive tests. The goal is to under…

This study tests a web-based tool that gives personalized estimates of benefits and risks of obesity treatments (like surgery or medications) to help doctors and patients with type 2 diabetes and severe obesity make informed decisions. About 10,000 adults across 40 primary care c…

This study looks at 54 obese women getting knee replacements to see if a stemmed implant (with a long rod) helps prevent the bone from collapsing inward or the implant from loosening compared to a standard implant. The goal is to find which design works better for heavier patient…

This study looks at how tirzepatide, a weight-loss drug, changes breast tissue and blood markers linked to breast cancer risk. About 20 women with obesity and other breast cancer risk factors will take tirzepatide for 3-6 months. Researchers will measure changes in breast density…

This study aimed to find the best air pressure settings on a breathing machine for very obese patients to help them breathe on their own after a breathing tube is removed. It planned to test different pressure levels in about 20 patients. However, the study was withdrawn before a…

This study looks at how the type of protein you eat on a high-protein ketogenic diet changes weight loss and body inflammation. Researchers will follow 60 adults with obesity for 12 weeks, measuring weight, body fat, and immune cells in fat tissue. The goal is to understand which…

This study looks at how long you need to fast and how stopping the diabetes drug tirzepatide changes the amount of food and liquid left in your stomach after a meal. Researchers will use ultrasound to check stomach contents in 40 adults with type 2 diabetes or obesity. The goal i…

This study looks at how nutritional counseling and physical exercise affect aging markers in elderly women. Researchers will measure telomere length and other signs of cellular aging in 80 women aged 60-75, some with obesity and some without. The goal is to see if lifestyle chang…

This study looks at whether patient navigators (health coaches) can help more adults with obesity sign up for and attend weight management programs. About 171 participants will be split into two groups: one gets a navigator, the other does not. The goal is to see if this support …

This study follows 240 teenagers and young adults aged 13-21 to see how weight-loss surgery (gastric bypass or sleeve gastrectomy) impacts bone density and strength over two years. It compares those who have surgery with overweight teens who do not. The goal is to understand if t…

This observational study follows 163 obese adults undergoing bariatric surgery in Bahrain. Researchers aim to create a non-invasive scoring system using blood markers and ultrasound to diagnose and monitor fatty liver disease (MASLD), potentially replacing the need for liver biop…

This early-phase study aims to understand how well people with obesity tolerate glucagon, a hormone that may help with weight loss. About 20 healthy obese adults will receive increasing doses of glucagon through an IV, and researchers will measure when they start feeling nauseous…

This study looks for biological markers that may explain why some people experience a larger-than-expected drop in their resting metabolism when they lose weight. Researchers will follow 60 adults with obesity for 18 months, measuring metabolism and hormone levels. The goal is to…

This study looks at whether taking weekly cold water baths (18°C) for at least 12 weeks can boost brown fat activity in adults with obesity. Brown fat is a type of body fat that burns energy to generate heat. Researchers will use special scans to measure blood flow and fuel use i…

This study follows 60 adults who completed an 18-month weight loss program 3 years ago. Researchers will measure changes in weight, body fat, and muscle, and track physical activity, sleep, and eating patterns using wearable devices and a phone app. The goal is to understand how …

This study looks at how eating habits affect weight loss after bariatric surgery. Researchers will compare people who lost a lot of weight with those who lost less, to see if diet plays a role. About 44 adults who had sleeve gastrectomy surgery will take part. The goal is to unde…

This study follows over 31,000 adults aged 45 and older to understand how being overweight or having high blood pressure increases the risk of heart problems like heart attacks and strokes. Researchers will track participants until 2026, recording major heart events. No treatment…

This study was designed to see if adding pramlintide to semaglutide helps control appetite and eating habits in obese people with prediabetes. Researchers planned to give 40 participants weekly semaglutide injections for 24 weeks, then add either pramlintide or a placebo for two …

This study looks at how exercise changes fat (adipose) tissue and how those changes might improve health as we age or if we have obesity. Researchers will measure immune cells and inflammatory markers in fat tissue samples from 56 healthy adults before and after exercise. The goa…

This study collects blood, urine, and tissue samples from 500 adults with obesity to help researchers learn why people gain or lose weight, and why some regain weight after treatment. Participants must be over 18 and have a BMI of 30 or higher. The samples will be stored for up t…

This study looks at whether weight loss from Roux-en-Y gastric bypass (RYGB) surgery changes bile acids differently than weight loss from cutting calories alone. Researchers will measure bile acid levels in stool samples from 21 adults with severe obesity. The goal is to understa…

This study aimed to see if using wearable devices and game-like features could encourage hospital patients with heart conditions to walk more. It was designed for adults aged 50 and older admitted to medicine or cardiology floors. However, the study was withdrawn before any parti…

This study looks at how negative emotions change the way the brain processes food rewards and choices in people with binge eating disorder or bulimia. Researchers will use brain scans and real-life mood tracking to understand these links. The goal is to find brain-based targets f…

This study looks at how losing weight with prescription drugs changes certain inflammatory cells and blood fats that may be linked to cancer risk. About 30 adults with obesity (BMI over 30, ages 35-60) will be followed for 6 months. Researchers will measure weight loss, inflammat…

This study tracks how GLP-1 medications like semaglutide and tirzepatide affect food cravings and diet quality in people with overweight or obesity. Over 24 weeks, up to 150 adults will fill out questionnaires about their eating habits and cravings. The goal is to understand how …

This study looks at whether an 8-week eccentric (lengthening) strength training program is better than standard concentric (shortening) training for improving muscle strength, body composition, and blood sugar in obese, inactive women aged 25-45. Participants will train twice and…

This study looked at how the body's internal clock affects heart disease risk in people with obesity. Researchers compared lean and overweight adults by measuring blood pressure and other heart markers at different times of day. Because only 17 people took part, the results are n…

This study looks at whether giving Fitbit smartwatches to adults aged 65 and older in a doctor-referred exercise program helps them become more active. Researchers want to see if the program is easy to use and if participants like wearing the devices. The goal is to improve physi…

This study looks at whether measuring body water using a harmless electrical test can help detect obstructive sleep apnea (OSA) in pregnant women with severe obesity. OSA is common but often missed in this group and can be dangerous for both mother and baby. The goal is to find a…

This study tests if two different ways of giving survodutide—a pre-filled syringe and a pre-filled pen—deliver the drug into the body in the same way. About 56 healthy or overweight adults will receive a single dose of each method and have their blood levels measured. The goal is…

This study looks at how the weight-loss drug Saxenda (liraglutide) changes brain activity related to appetite and food cravings. Researchers will use brain scans to see how the drug affects areas that control eating. The study involves 28 obese adults and aims to understand the b…

This study looks at how a personalized, calorie-restricted diet affects metabolism in overweight or obese Chinese adults. Researchers will measure how the body uses energy and burns fat and carbs before and after a 12-week diet plan. The goal is to understand why people respond d…

This study will follow 5,000 adults who have had an endoscopic procedure for weight loss or to fix a previous weight-loss surgery. Researchers will track changes in weight, blood pressure, diabetes, and cholesterol for up to 10 years. The goal is to learn how well these procedure…

This study looks at why some people with obesity develop health problems like diabetes and heart disease while others don't. Researchers will compare three popular weight loss diets—Mediterranean, low-carb, and very-low-fat plant-based—in 180 people with obesity. The goal is to u…

This study looks at whether liraglutide (Saxenda®), a drug used for weight loss, can increase a brain-health marker called BDNF in people with multiple sclerosis, long-COVID, or leukemia (in remission) who also have obesity and memory or thinking problems. About 30 participants w…

This study is a review of many smaller trials that looked at what happens when people replace animal proteins (like meat, dairy, eggs) with plant proteins (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weigh…

This study looks at how different types of dairy fat affect inflammation in people with metabolic syndrome or obesity. Participants eat a high-fat meal and have their blood tested over six hours. The goal is to understand how dairy fat components influence the body's inflammatory…

This study was designed to see if taking fish oil before exercise could help reduce inflammation in people with obesity. Researchers planned to measure changes in blood markers and gut bacteria over 6 weeks. However, the study was withdrawn before any participants were enrolled, …

This study looks at how two types of weight-loss surgery—gastric bypass and sleeve gastrectomy—affect people's social experiences and feelings of well-being. About 113 adults scheduled for surgery will track their daily social interactions and mood for two weeks, both before and …

This study looks at how the weight-loss drug lorcaserin affects brain areas that control appetite and eating. About 40 adults with obesity will have brain scans (fMRI) and body composition tests before and after treatment. The goal is to understand the brain changes behind the dr…

This study uses a mobile app to figure out which types of help work best for people who struggle with binge eating and obesity. About 300 adults will use the app, and researchers will track changes in binge eating episodes. The goal is to learn what helps, for whom, and in what o…

This study tests whether a patient navigator (a personal guide) can help adults with overweight or obesity choose and stick with a weight loss program. 68 participants will work with a navigator for 12 months. The goal is to see if this approach improves weight loss and program e…

This study looks at how eating foods that are highly rewarding (like tasty treats) versus less rewarding foods affects brown fat—a type of fat that burns energy. Researchers will scan the brain and brown fat of 30 volunteers (some lean, some with obesity) to see how food cues and…

This study aims to understand how bariatric surgery improves the way the body handles sugar and fat. Researchers will collect tissue and blood samples from 500 people having weight-loss surgery or other procedures. By studying these samples, they hope to learn the molecular signa…

This study looks at how eating cheese, compared to a non-dairy cheese substitute, affects inflammation in the body over six hours. Researchers will measure inflammatory markers in the blood of 20 adults with metabolic syndrome or obesity. The goal is to understand whether dairy f…

This study looks at how a hormone called angiotensin-(1-7) affects how many calories people with obesity burn at rest. Researchers will measure energy use and check fat tissue for signs of heat production. The goal is to better understand the body's energy balance, not to test a …

This study looks at how to help VA medical centers offer virtual programs that prevent heart disease, diabetes, and depression in women Veterans. It involves 20 VA sites across 4 regions, testing two different support strategies. The goal is to see which approach gets more women …

This study looks at why a special type of body fat (brown fat) that burns calories stops working in people with obesity. Researchers will take small samples of fat and blood from 8 volunteers before and after warming up to find the molecules that turn off this calorie-burning pro…

This study looks at how the body handles carbohydrates and fats after eating, in African American and white adults with obesity. Participants will eat a standard or low-carb meal before and after losing about 16-18% of their weight through a low-calorie diet or gastric bypass sur…

This study looks at how insulin in the brain changes blood flow and nerve activity in healthy adults aged 18-45. Researchers will measure blood flow in the brain and legs, and nerve signals to muscles. No treatment is given—this is an observation-only study to better understand h…

This study looks at how changing what you eat can help people lose more weight after bariatric surgery. About 44 patients who had sleeve gastrectomy will take part. Researchers will measure hunger, calorie intake, and energy use to see if diet habits make a difference.

This study looks at why Black people with HIV are more likely to develop kidney disease, diabetes, and heart problems. Researchers are analyzing genetic and health data from over 3,000 participants to find risk factors. The goal is to better understand these diseases and improve …

This study looks at how the tightening of blood vessels (called sympathetic vasoconstriction) may reduce the ability of insulin to widen blood vessels and take up sugar. Researchers will test this by temporarily blocking the tightening signal in the forearm of 36 adults with obes…

This study looks at why storing fat in and around organs like the liver affects some people's health more than others. Researchers will measure insulin sensitivity and inflammation in 144 lean and obese adults. The goal is to better understand these differences to help develop fu…

This study tests whether a special belt (EIT) can help doctors set the right breathing machine pressure for obese patients during abdominal surgery. About 20 adults with a BMI of 40 or higher will take part. The goal is to see if the belt works better than standard methods to avo…

This study looks at why some people lose more weight than others after bariatric surgery. Researchers will use brain scans (PET) to measure changes in the brain's reward system, specifically dopamine receptors, in 30 adults who had surgery 2-3 years ago. The goal is to understand…

This study aims to find genetic variations that increase the risk of type 2 diabetes, its complications like kidney disease, and related conditions such as obesity. Over 2,300 adults, especially American Indians and Mexican Americans, will provide health history, blood samples, a…

This study tests a 6-month program for adults with obesity (BMI 30 or higher) that aims to improve mental, social, and physical health without focusing on weight loss. Participants learn intuitive eating and body acceptance techniques. The goal is to see if this approach is feasi…

The design is an open-ended prospective observational (non-interventional) registry for subjects living with excess weight or obesity under the care of a qualified provider with documented experience treating patients with obesity