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Can a 60-year-old diet pill finally be approved for long-term weight loss?

NCT ID NCT05176626

First seen Apr 25, 2026 · Last updated Apr 30, 2026 · Updated 2 times

Summary

This study looks at whether the weight-loss drug phentermine, which is currently only approved for short-term use (up to 12 weeks), is safe and effective when taken for up to 2 years. About 870 adults with obesity or overweight plus related health issues will take the drug and be monitored for weight loss, blood pressure changes, and side effects. The goal is to see if long-term use can help manage obesity as a chronic disease.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Atrium Health Wake Forest Baptist Weight Management Center

    Winston-Salem, North Carolina, 27104, United States

  • HealthPartners Institute

    Saint Louis Park, Minnesota, 55416, United States

  • Kaiser Permanente Southern California

    Los Angeles, California, 90034, United States

  • UT Center for Obesity Medicine and Metabolic Performance

    Bellaire, Texas, 77401, United States

Conditions

Explore the condition pages connected to this study.