500 obese adults donate samples to unlock secrets of weight loss
NCT ID NCT05874726
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study collects blood, urine, and tissue samples from 500 obese adults to help researchers understand why people gain weight, lose weight, or regain weight after treatment. Participants must be over 18 with a BMI of 30 or higher. The samples will be stored for up to 10 years and used to study obesity, diabetes, and related conditions.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could help identify biomarkers that predict who will respond best to weight-loss treatments, leading to more personalized care.
- What could go wrong
- This is an observational sample-collection study, not a treatment trial. It will not directly benefit participants and may not yield actionable findings for years.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 500 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Jul 2023
- Expected to finish
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Apr 2029
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
The purpose of this repository is to study obesity, as well as the effects of weight loss therapies on several clinical, physiological, hormonal and biochemical parameters. Therefore, enrollment in this repository will be limited to patients with obesity undergoing evaluation for weight loss through medical, endoscopic or surgical means. Obesity is a condition that affects all ethnic and racial groups. Investigators do not anticipate that any particular group of patients will be disproportionately represented. Although obesity affects both children and adults, this repository will be limited to adult patients, which represent the practices of the physicians involved in this protocol.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Be older than 18 years of age, * Suffer from obesity, defined by BMI≥30 kg/m2 (body mass index: weight in kilograms divided by the square of the height in meters). Exclusion Criteria: * Positive laboratory tests for any of the following pathogens: Hepatitis B virus (HBV); Hepatitis C virus (HCV); Human Immunodeficiency Virus Types 1 and 2 (HIV); Human T-Lymphotropic virus Types I and II (HTLV); Treponema pallidum (syphilis); Clostridium Difficile (C. Diff) * History of gastrointestinal malabsorptive disorders including a known history of celiac disease, and/or chronic pancreatitis, * History of any inflammatory disease of the gastrointestinal tract, * Patient is of childbearing age and not practicing effective birth control method, pregnant or lactating * History of a myocardial infarction or cerebro-vascular accident in the last year, or history of unstable cardiovascular disease, * History of cancer or life expectancy of \< 2 yrs, * Use of any medications (prescription or OTC), including herbal or other supplements for treatment of obesity, * History of known hormonal or genetic cause for obesity, * History of any psychiatric disorders including dementia, active psychosis, severe depression requiring \> 2 medications, history of suicide attempts, alcohol or drug abuse within the previous 12 months, * Any condition or major illness that, in the investigator's judgment, places the subject at undue risk of participating in the repository, * Unable to understand the risks, realistic benefits and requirements of the repository, * Use of investigational therapy or participation in any other clinical trial within 12 weeks prior to signing the ICF.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Brigham and Women's Hospital
Boston, Massachusetts, 02115, United States
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