SLEEP APNEA

This study follows 225 adults with moderate-to-severe obstructive sleep apnea who receive the Inspire hypoglossal nerve stimulation implant. The device is for people who cannot use or tolerate CPAP machines. Researchers will track how well the implant reduces breathing pauses dur…

This study tests a new device called the remedē Dual Channel System for people with severe sleep apnea. The device is implanted in the body and works during sleep to prevent breathing interruptions. The study will check if the device is safe and if it improves breathing during sl…

This study tests whether bexagliflozin, a drug used for diabetes, can reduce the severity of sleep apnea in overweight or obese adults. About 164 participants will receive either the drug or a placebo for 6 months while continuing routine care. The goal is to see if the drug impr…

This study tests a new device called the Lunair Alpha System, which uses mild nerve stimulation to treat moderate to severe sleep-disordered breathing (like sleep apnea). It is for people who cannot use or do not get relief from standard treatments. The study will check if the de…

This study looks at whether a sleep medication (eszopiclone) can help people with obstructive sleep apnea use their CPAP machine more consistently and improve their thinking skills. Researchers will study 250 adults with sleep apnea over 3 months. The goal is to see if raising th…

This study looks at whether oxygen, finasteride, and acetazolamide can help reduce sleep apnea in people aged 60 and older with mild to moderate sleep apnea. Researchers will measure breathing stability and sleep quality. The goal is to find new, non-invasive treatments to improv…

This study looks at ways to treat sleep apnea in people who have had a cervical spinal cord injury for more than 6 months. Researchers will measure changes in breathing and sleep quality. About 100 adults aged 18 to 89 with chronic spinal cord injury (T6 and above) can join. The …

This study tests whether breathing air with slightly higher carbon dioxide (hypercapnia) for two weeks can improve breathing and reduce sleep apnea in veterans with spinal cord injury. About 30 adults with chronic spinal cord injury or able-bodied people with sleep apnea will tak…

This study will follow 1,000 adults who are referred to a sleep clinic with possible sleep apnea. Participants will have a sleep test, 24-hour blood pressure monitoring, and fill out questionnaires about sleepiness and quality of life. Those diagnosed with sleep apnea will receiv…

This study looks at whether a daytime sleep test works as well as an overnight one to adjust the Inspire device for people with obstructive sleep apnea. About 110 adults who already have the Inspire implant will take part. The goal is to see if daytime testing can save time and r…

This study looks at how sleep apnea changes pressure in the brain and belly during sleep, which can affect how well a cerebrospinal fluid shunt works. Researchers will measure these pressures in 30 people with normal-pressure hydrocephalus to help decide whether to drain fluid in…

This study follows 35 people with severe obesity who are having mini-gastric bypass surgery as part of their routine care. Researchers want to see how the surgery helps improve related health issues like type 2 diabetes, sleep apnea, high blood pressure, and fatty liver disease. …