GASTROESOPHAGEAL REFLUX

This study aims to see if a new office-based test can detect Barrett's esophagus—a condition that can lead to esophageal cancer—in people who do not have chronic heartburn. About 800 adults will answer a questionnaire, swallow a capsule balloon to collect cells, and have a lab te…

This study tests whether wearing an external band around the upper throat can reduce nighttime symptoms like cough, choking, or regurgitation in people with GERD. About 350 adults with reflux-related ear, nose, and throat issues will try the band and report how their symptoms cha…

This study tests two common treatments for infant reflux: a cow-milk-protein-free diet and the medication omeprazole. About 96 infants under 1 year old with frequent reflux and symptoms like crying or poor weight gain will take part. The goal is to see which approach works better…

This program gives domperidone to teens aged 12 to 21 who have severe stomach or reflux symptoms that haven't gotten better with standard treatments. The goal is to see if the drug can reduce their symptoms. Up to 20 participants will be enrolled.

This study looks at whether hydrotalcite (Talcid) can relieve acid-related symptoms like heartburn that occur after stopping long-term use of proton pump inhibitors (PPIs). About 167 adults in Germany who have stopped taking PPIs and are experiencing rebound symptoms will take hy…

This study looks at whether a special probe can predict who will develop acid reflux after gastric sleeve surgery. Researchers will follow 200 adults to see if measurements taken during surgery can spot early warning signs. The goal is to help doctors prevent or manage this commo…

This study looks at how often people who take proton pump inhibitors (PPIs) for acid reflux develop a condition called small intestinal bacterial overgrowth (SIBO). Researchers will use breath tests and symptom questionnaires to measure this in 50 adults. The goal is to better un…