GERD

This study tests a procedure called TIF for people with GERD who still have symptoms despite medication. TIF rebuilds the valve between the stomach and esophagus using a tube inserted through the mouth, avoiding surgery cuts. The goal is to reduce acid reflux and the need for dai…

This study tests whether Vonaprazan, a newer acid blocker, works better than the standard drug Esomeprazole for healing moderate-to-severe esophagitis caused by acid reflux after POEM surgery for achalasia. About 300 adults who had POEM and developed reflux esophagitis will take …

This study tests if using a special mesh (Ovitex) during hernia repair surgery works better than stitches alone to keep the hernia from coming back within two years. About 164 adults with large hiatal hernias will take part. Researchers will also check how patients feel and their…

This study is testing a new FDA-approved device that measures electrical signals in the throat to help doctors diagnose GERD and eosinophilic esophagitis more accurately. About 50 adults with chronic reflux or swallowing problems will use the device during an upper endoscopy. The…

This study compares two medications, zastaprazan and esomeprazole, to see which one better relieves nighttime heartburn in people with erosive GERD. About 160 Korean adults with nighttime heartburn for over 3 months will take one of the drugs and report sleep disturbances. The go…

This study tests whether a new drug called vonaprazan (at 10 mg or 20 mg) works better than the standard medicine esomeprazole (40 mg) for healing damage to the esophagus caused by acid reflux. About 414 adults with moderate to severe reflux esophagitis will take one of the three…

This study tests if special breathing exercises can help people with GERD (heartburn and reflux). 42 adults will either do diaphragmatic breathing, use a spirometer (a breathing device), or receive standard care for 6 weeks. Researchers will check if these exercises reduce acid r…

This program gives domperidone to teens aged 12 to 21 who have severe stomach or reflux symptoms that haven't gotten better with standard treatments. The goal is to see if the drug can reduce their symptoms. Up to 20 participants will be enrolled.

This study is a registry that will collect medical information from up to 10,000 people with esophageal problems like GERD, achalasia, and other swallowing disorders. Researchers will gather data from standard tests to better understand these conditions. The goal is to improve di…

This study aims to understand how the upper part of the esophagus and throat normally prevent stomach contents from flowing backward into the throat. Researchers will measure muscle pressures and use a camera to detect when acid actually reaches the throat. The study includes 300…

This study checks if a new orally disintegrating tablet of Trimedat (76.95 mg) works the same as the standard 100 mg tablet in 36 healthy adults. Participants take both forms at different times to compare how the drug is absorbed and processed. The goal is to see if the new versi…