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New weekly shot aims to tackle diabetes, obesity, and sleep apnea

NCT ID NCT05929079

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jul 31, 2026 · Updated 2 times

Summary

This Phase 3 trial tests retatrutide, a once-weekly injection, in 1000 adults with type 2 diabetes who are overweight or obese. The study also looks at a subset of participants with obstructive sleep apnea. Over 89 weeks, researchers will measure weight loss, changes in sleep apnea severity, and other health markers. The goal is to see if the drug is safe and effective for managing these conditions together.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
retatrutide (a once-weekly injection)
What this could lead to
If it works, this could offer a new weekly injection to help people with type 2 diabetes and obesity lose weight and improve sleep apnea.
What could go wrong
This is a large Phase 3 trial, but results are not yet available. The drug may cause side effects or not work better than placebo. It is not a cure and requires ongoing use.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

1,152 people

The number who actually took part.

Started

Jul 2023

Finished

Jun 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a body mass index (BMI) greater than or equal to 27.0 kilogram/square meter (kg/m ²) * Have Type 2 Diabetes (T2D) * Are on stable treatment for T2D for at least 90 days * Have a history of at least one unsuccessful dietary effort to lose body weight. GSA2 Inclusion Criteria * Previously diagnosed with OSA * Have AHI ≥15 on polysomnography at screening (definition of moderate-to-severe OSA) * For participants not on positive airway pressure (PAP) therapy: unable or unwilling to use PAP therapy and have not used PAP for at least 4 weeks prior to screening. * If on PAP therapy, have been on PAP therapy for at least 3 consecutive months prior to screening, and willing to temporarily stop using PAP therapy for approximately 7 days prior to each of the sleep study (PSG) visits. Exclusion Criteria: * Have a self-reported or documented change in body weight \>5 kg (11 pounds) within 90 days. * Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening. * Have a prior or planned surgical treatment for obesity. * Have Type 1 diabetes * Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2) * Have had pancreatitis GSA2 Exclusion Criteria * Use stimulants (for example, modafinil, armodafinil, solriamfetol, pitolisant, amphetamine) less than 3 months prior to screening. * Use hypnotics, mirtazapine, opioids, trazodone, and zonisamide less than 3 months prior to screening. * Use a dental appliance or other device to treat OSA other than PAP therapy.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder obstructive sleep apnea syndrome Overweight type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity Obstructive sleep apnea Overweight Type 2 diabetes

Contacts and locations

Locations

  • Advanced Research Institute

    Ogden, Utah, 84405, United States

  • Advara HeartCare Joondalup

    Joondalup, Western Australia, 6027, Australia

  • All India Institute of Medical Sciences

    Raipur, Chhattisgarh, 492099, India

  • Arké SMO S.A de C.V

    Veracruz, Veracruz, 91910, Mexico

  • Austin Health - Repatriation Hospital

    Heidelberg West, Victoria, 3081, Australia

  • Avron Hospitals

    Ahmedabad, Gujarat, 380013, India

  • BR Trials - Ensaios Clinicos e Consultoria

    São Paulo, São Paulo, 01236030, Brazil

  • Box Hill Hospital

    Box Hill, Victoria, 3128, Australia

  • Brengle Family Medicine

    Indianapolis, Indiana, 46260, United States

  • CARE CHL-Hospitals

    Indore, Madhya Pradesh, 452008, India

  • CEPIC - Centro Paulista de Investigação Clínica

    São Paulo, São Paulo, 04266-010, Brazil

  • CMI Dr.Pletea Noemi SRL

    Bacau, Bacău, 600154, Romania

  • CPQuali Pesquisa Clínica

    São Paulo, São Paulo, 01228-000, Brazil

  • CTI Clinical Research Center

    Cincinnati, Ohio, 45212, United States

  • Cardiolink Clin Trials

    Monterrey, Nuevo León, 64060, Mexico

  • Care Hospitals Hyderabad- Banjara Hills

    Hyderabad, Telangana, 500034, India

  • Carteret Medical Group

    Morehead City, North Carolina, 28557, United States

  • Centricity Research Rincon Pulmonology

    Rincon, Georgia, 31406, United States

  • Centro Especializado En Diabetes, Obesidad Y Prevencion De Enfermedades Cardiovasculares

    Mexico City, Mexico City, 11650, Mexico

  • Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

    Buenos Aires, Buenos Aires F.D., C1425AGC, Argentina

  • Centro Médico Viamonte

    Buenos Aires, Buenos Aires F.D., C1120AAC, Argentina

  • Centro Periférico de Especialidades Bola Azul

    Almería, Almería, 04009, Spain

  • Centro de Investigacion en Artritis y Osteoporosis SC

    Mexicali, Estado de Baja California, 21200, Mexico

  • Centro de Salud e Investigaciones Médicas

    Santa Rosa, La Pampa Province, 6300, Argentina

  • Centrul Medical Mediab

    Târgu Mureş, Mureș County, 540142, Romania

  • Centrul Medical NutriLife

    Bucharest, Bucharest, 013764, Romania

  • Chase Medical Research, LLC

    Waterbury, Connecticut, 06708, United States

  • Christian Medical College Vellore

    Vellore, Tamil Nadu, 632004, India

  • Clinica Omega

    Mexico City, Mexico City, 06700, Mexico

  • Clinical Research Center of Florida

    Pompano Beach, Florida, 33060, United States

  • Clinical Site Partners LLC, dba Flourish Research

    Miami, Florida, 33186, United States

  • Clinical Site Partners, LLC dba Flourish Research

    Winter Park, Florida, 32789, United States

  • Complejo Asistencial Universitario de León - Hospital de León

    León, Castille and León, 24071, Spain

  • Consultorio de Investigación Clínica EMO SRL

    Buenos Aires, Buenos Aires F.D., 1405, Argentina

  • Core Healthcare Group

    Cerritos, California, 90703, United States

  • Core Research Group

    Brisbane, Queensland, 4064, Australia

  • Cullman Clinical Trials

    Cullman, Alabama, 35055, United States

  • Diabdana

    Oradea, Bihor County, 410147, Romania

  • Diabetes Research Center

    Hyderabad, Telangana, 500082, India

  • Diablo Clinical Research, Inc.

    Walnut Creek, California, 94598, United States

  • Diseno y Planeacion en Investigacion Medica

    Guadalajara, Jalisco, 44130, Mexico

  • East-West Medical Research Institute

    Honolulu, Hawaii, 96814, United States

  • Emeritus Research

    Botany, New South Wales, 2019, Australia

  • Emeritus Research

    Camberwell, Victoria, 3124, Australia

  • Excel Medical Clinical Trials

    Boca Raton, Florida, 33434, United States

  • FAICIC S. de R.L. de C.V.

    Veracruz, Veracruz, 91900, Mexico

  • Fleming Island Center for Clinical Research

    Fleming Island, Florida, 32003, United States

  • Flinders University

    Bedford Park, South Australia, 5042, Australia

  • FutureSearch Trials of Neurology

    Austin, Texas, 78731, United States

  • Gama Diamed

    Mangalia, Constanța County, 905500, Romania

  • Geea Medical Easy Diet

    Bucharest, Bucharest, 010627, Romania

  • H.R.U Málaga - Hospital Civil

    Málaga, Andalusia, 29009, Spain

  • Hospital Universitario Ramón y Cajal

    Madrid, Madrid, Comunidad de, 28034, Spain

  • Hospital Universitario Virgen Del Rocio

    Seville, Sevilla, 41013, Spain

  • Hospital Universitario Virgen de la Victoria

    Málaga, Andalusia, 29010, Spain

  • Institute of Post Graduate Medical Education and Research and Seth Sukhlal Karnani Memorial Hospital

    Kolkata, West Bengal, 700020, India

  • Intrepid Research

    Cincinnati, Ohio, 45245, United States

  • Investigacion En Salud Y Metabolismo S.C / Nutricion Clinica / Unidad de Base de Datos

    Chihuahua City, Chihuahua, 31110, Mexico

  • Las Vegas Medical Research

    Las Vegas, Nevada, 89128, United States

  • Life Care Hospital and Research Centre

    Bangalore, Karnataka, 560092, India

  • Lillestol Research

    Fargo, North Dakota, 58104, United States

  • Madras Diabetes Research Foundation

    Chennai, Tamil Nadu, 600086, India

  • MedVadis Research Corporation

    Waltham, Massachusetts, 02451, United States

  • Mid Hudson Medical Research

    New Windsor, New York, 12553, United States

  • Monroe Biomedical Research

    Monroe, North Carolina, 28112, United States

  • Mysore Medical College

    Mysore, Karnataka, 570001, India

  • NeuroTrials Research Inc

    Atlanta, Georgia, 30328, United States

  • Nightingale Research

    Adelaide, South Australia, 5000, Australia

  • Northwest Clinical Research Center

    Bellevue, Washington, 98007, United States

  • Palm Beach Research Center

    West Palm Beach, Florida, 33409, United States

  • Pinnacle Research Group, LLC

    Anniston, Alabama, 36207, United States

  • Preferred Primary Care Physicians

    Uniontown, Pennsylvania, 15401, United States

  • Preferred Primary Care Physicians, Preferred Clinical Research (Ofc 18)

    Pittsburgh, Pennsylvania, 15236, United States

  • Preferred Research Partners

    Little Rock, Arkansas, 72211, United States

  • Private Practice - Dr. Arechavaleta Granell Maria del Rosario

    Guadalajara, Jalisco, 44670, Mexico

  • Quantum Clinical Trials

    Miami Beach, Florida, 33140, United States

  • RM Pharma Specialists

    Mexico City, Mexico City, 03100, Mexico

  • Renstar Medical Research

    Ocala, Florida, 34470, United States

  • Royal Brisbane and Women's Hospital

    Brisbane, Queensland, 4029, Australia

  • Sawai Man Singh Medical College Hospital (SMS Hospital)

    Jaipur, Rajasthan, 302004, India

  • Southern Adelaide Diabetes & Endocrine Services

    Oaklands Park, South Australia, 5046, Australia

  • StudyMetrix Research

    City of Saint Peters, Missouri, 63303, United States

  • Sushruta Multispeciality Hospital & Research Centre

    Hubli, Karnataka, 580021, India

  • Teradan Clinical Trials, LLC

    Brandon, Florida, 33511, United States

  • The AIM Centre / Hunter Diabetes Centre

    Merewether, New South Wales, 2291, Australia

  • Therafirst Medical Center

    Fort Lauderdale, Florida, 33308, United States

  • Trial Management Associates

    Myrtle Beach, South Carolina, 29572, United States

  • Tribe Clinical Research - Spartanburg

    Spartanburg, South Carolina, 29301, United States

  • Tribe Clinical Research, LLC

    Greenville, South Carolina, 29607, United States

  • Unidad biomedica avanzada monterrey

    Monterrey, Nuevo León, 64460, Mexico

  • Unidad de Investigación Clínica y Atención Médica HEPA

    Guadalajara, Jalisco, 44670, Mexico

  • V.S. General Hospital

    Ahmedabad, Gujarat, 380006, India

  • Valley Clinical Trials, Inc.

    Northridge, California, 91325, United States

  • Velocity Clinical Research, Dallas

    Dallas, Texas, 75230, United States

  • Velocity Clinical Research, Westlake

    Los Angeles, California, 90057, United States

  • Vithas Hospital Sevilla

    Seville, Sevilla, 41950, Spain

  • Woolcock Institute of Medical Research

    Macquarie Park, New South Wales, 2113, Australia

  • Zydus Hospitals & Healthcare Research Pvt.Ltd.

    Ahmedabad, Gujarat, 380054, India

More trials for these conditions

Other studies related to the condition(s) this trial covers.