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New obesity drug retatrutide takes on tirzepatide in major trial

NCT ID NCT06662383

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jul 21, 2026 · Updated 3 times

Summary

This phase 3 trial tests whether retatrutide is better than tirzepatide for weight loss in 800 adults with obesity. Participants receive one of the two drugs for about 89 weeks. The study measures changes in body weight, BMI, waist size, and other health markers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
retatrutide (a drug) compared to tirzepatide (a drug)
What this could lead to
If retatrutide works better than tirzepatide, it could offer a more effective weight-loss option for people with obesity.
What could go wrong
This is a head-to-head comparison, not a cure. Both drugs are already approved for other uses, but retatrutide may not prove superior or could have unexpected side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

About 800 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2024

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have obesity and a history of at least one self-reported unsuccessful dietary effort to reduce body weight. Exclusion Criteria: * Have a self-reported change in body weight \>5 kilograms (kg) (11 pounds) within 90 days before screening. * Have a prior or planned surgical treatment for obesity. * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity. * Have taken weight loss drugs, including over-the-counter medications, within 90 days prior to screening. * Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN-2). * Have had within the past 90 days before screening: * acute myocardial infarction * cerebrovascular accident (stroke) * coronary revascularization * hospitalization for unstable angina, or * hospitalization due to congestive heart failure. * Have New York Heart Association Functional Classification Class IV congestive heart failure. * Have a history of chronic or acute pancreatitis.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity

Contacts and locations

Locations

  • Accellacare - Wilmington

    Wilmington, North Carolina, 28401, United States

  • Albany Medical College, Division of Community Endocrinology

    Albany, New York, 12203, United States

  • AmBeNet GmbH

    Leipzig, Saxony, 04107, Germany

  • Artemis Institute for Clinical Research

    San Diego, California, 92103, United States

  • Bridgeport Hospital

    Bridgeport, Connecticut, 06610, United States

  • Centro Medico Dra. Laura Maffei- Investigacion Clinica Aplicada

    Buenos Aires, Buenos Aires F.D., C1425AGC, Argentina

  • Centro Médico Viamonte

    Buenos Aires, Buenos Aires F.D., C1120AAC, Argentina

  • Centro de Investigaciones Metabólicas (CINME)

    Buenos Aires, C1056ABI, Argentina

  • Centrum Terapii Wspolczesnej J. M. Jasnorzewska Spolka Komandytowo-Akcyjna

    Lodz, Łódź Voivodeship, 90-338, Poland

  • Centrum Zdrowia Metabolicznego Pawel Bogdanski

    Poznan, Greater Poland Voivodeship, 60-589, Poland

  • Charlottesville Medical Research

    Charlottesville, Virginia, 22911, United States

  • Chrysalis Clinical Research

    St. George, Utah, 84790, United States

  • ClinCept Clinical Research - MH

    Columbus, Georgia, 31904, United States

  • Consano Clinical Research, LLC

    Shavano Park, Texas, 78231, United States

  • Consultorio de Investigación Clínica EMO SRL

    Buenos Aires, Buenos Aires F.D., C1405BUB, Argentina

  • DIM Clínica Privada

    Ramos Mejía, Buenos Aires, B1704ETD, Argentina

  • Diabetes Zentrum Wilhelmsburg

    Hamburg, 21109, Germany

  • Diabeteszentrum Hamburg West

    Hamburg, 22607, Germany

  • Diabetologische Schwerpunktpraxis Dr. Staudenmeyer & Dr. Schiwietz

    Lingen, Lower Saxony, 49808, Germany

  • Diablo Clinical Research, Inc.

    Walnut Creek, California, 94598, United States

  • East-West Medical Research Institute

    Honolulu, Hawaii, 96814, United States

  • Einstein Clinical Research

    Vero Beach, Florida, 32960, United States

  • Ekamed

    Lublin, Lublin Voivodeship, 20-718, Poland

  • Encompass Clinical Research

    Spring Valley, California, 91978, United States

  • Encore Medical Research

    Hollywood, Florida, 33024, United States

  • Gabinet Leczenia Otylosci i Chorob Dietozaleznych - dr hab. n. med. Lucyna Ostrowska

    Bialystok, Podlaskie Voivodeship, 15-281, Poland

  • Gabinety TERPA

    Lublin, Lublin Voivodeship, 20-333, Poland

  • Gemeinschaftspraxis Prof. Dr. med. Stephan Jacob, Dr. med. Frohmut Jacob

    Villingen-Schwenningen, Baden-Wurttemberg, 78048, Germany

  • Great Lakes Research Group, Inc.

    Bay City, Michigan, 48706, United States

  • Great Lakes Research Institute

    Southfield, Michigan, 48075, United States

  • Headlands Horizons LLC

    Brownsville, Texas, 78526, United States

  • Houston Research Institute

    Houston, Texas, 77079, United States

  • InnoDiab Forschung Gmbh

    Essen, North Rhine-Westphalia, 45136, Germany

  • Integrated Clinical Trial Services, Inc.

    West Des Moines, Iowa, 50265, United States

  • Las Vegas Endocrinology

    Henderson, Nevada, 89074, United States

  • Lillestol Research

    Fargo, North Dakota, 58104, United States

  • Lynn Institute of Denver

    Aurora, Colorado, 80012, United States

  • Mary & Dick Allen Diabetes Center

    Newport Beach, California, 92663, United States

  • Medical Advancement Centers of Arizona

    Tempe, Arizona, 85283, United States

  • Medizentrum Essen Borbeck

    Essen, North Rhine-Westphalia, 45355, Germany

  • Monroe Biomedical Research

    Monroe, North Carolina, 28112, United States

  • NZOZ Przychodnia Specjalistyczna Andrzej Wittek, Henryk Rudzki

    Ruda Śląska, Silesian Voivodeship, 41-709, Poland

  • NZOZ Specjalistyczny Ośrodek Internistyczno-Diabetologiczny

    Bialystok, Podlaskie Voivodeship, 15-435, Poland

  • New York Gastroenterology Associates

    New York, New York, 10075, United States

  • Next Level Urgent Care

    Houston, Texas, 77057, United States

  • Northeast Georgia Medical Center

    Gainesville, Georgia, 30501, United States

  • Northwestern University

    Chicago, Illinois, 60611, United States

  • Nzoz Neuro-Kard Ilkowski i Partnerzy SPL

    Poznan, Greater Poland Voivodeship, 61-853, Poland

  • Onhealth Research Center

    Miami, Florida, 33186, United States

  • Pennington Biomedical Research Center

    Baton Rouge, Louisiana, 70808, United States

  • PharmQuest Life Sciences, LLC

    Greensboro, North Carolina, 27408, United States

  • Pivotal Research Solutions

    Stonecrest, Georgia, 30038, United States

  • Ponce Medical School Foundation Inc.

    Ponce, 00716, Puerto Rico

  • Precision Clinical Research

    Sunrise, Florida, 33351, United States

  • PriMED Clinical Research

    Dayton, Ohio, 45429, United States

  • RED-Institut GmbH

    Oldenburg in Holstein, Schleswig-Holstein, 23758, Germany

  • StudyMetrix Research

    City of Saint Peters, Missouri, 63303, United States

  • Suncoast Research Group

    Miami, Florida, 33135, United States

  • Tribe Clinical Research, LLC

    Greenville, South Carolina, 29607, United States

  • Uniwersytecki Szpital Kliniczny w Białymstoku

    Bialystok, Podlaskie Voivodeship, 15-276, Poland

  • WR-Clinsearch, LLC

    Chattanooga, Tennessee, 37421, United States

  • Westchester Medical Center

    Valhalla, New York, 10595, United States

  • Yale University School of Medicine

    New Haven, Connecticut, 06519, United States

  • Zdrowie Osteo-Medic

    Bialystok, Podlaskie Voivodeship, 15-351, Poland

  • Zentrum fur klinische Forschung - Köln

    Cologne, North Rhine-Westphalia, 51069, Germany

More trials for these conditions

Other studies related to the condition(s) this trial covers.