OBESITY

This study looks at two popular weight-loss medications, semaglutide and tirzepatide, and whether adding a structured exercise program helps people with obesity lose more fat while keeping muscle. About 48 adults aged 25-60 with a BMI between 30 and 40 will take one of the drugs …

This 12-week study tests whether Vibegron, a drug already approved for overactive bladder, can improve energy use, heart health, and physical and mental function in 40 middle-aged and older adults with obesity. Participants will be randomly assigned to receive either Vibegron or …

This study looks at whether professional dental cleaning can make semaglutide work better for children with severe obesity. About 50 kids will either get dental cleaning plus oral hygiene tips, or just the tips. Researchers will track changes in gum health, inflammation, and othe…

This study tests whether a probiotic called Akkermansia muciniphila can help obese children and adolescents aged 7 to 18 lose weight and improve their metabolic health. Participants will take the probiotic or a placebo for a period, and researchers will measure changes in weight,…

This study looks at whether a low-calorie diet rich in medium-chain triglycerides (MCTs) from traditional Minangkabau foods (like coconut milk) can improve metabolic health in 40 obese adults. Researchers will measure weight, waist size, blood pressure, blood sugar, cholesterol, …

This study tests whether adding the weight-loss drug orlistat to standard gout treatment helps obese patients lower uric acid levels and reduce gout attacks. 120 adults with both gout and obesity will take orlistat or a placebo for 24 weeks, along with diet and exercise advice. T…

This study tests a once-monthly injection called berobenatide to help adults with overweight or obesity lose weight. About 954 participants will receive either the drug or a placebo for 20 months. The goal is to see if the drug is safe and effective for weight loss, including in …

This study tests a program for women with severe obesity (BMI 40+) and early-stage endometrial cancer. The program includes weight loss medication, a hormone-releasing IUD, diet, and exercise to help them lose weight and improve health before surgery. The goal is to see if this a…

This study tests a program that combines medication (Naltrexone + Bupropion) with behavior therapy to help adults lose weight and quit smoking before bariatric surgery. Researchers will compare this approach to standard care in 64 people aged 18-65 who smoke and have obesity. The…

This study tests a new medicine called CagriSema to help people with obesity lose weight, whether or not they also have type 2 diabetes. About 2500 adults with a BMI of 35 or higher will get either CagriSema or the existing drug semaglutide for 83 weeks. The goal is to see which …

This study tests two different versions of the drug cagrilintide in 50 adults with overweight or obesity. Participants will receive injections of either version B or D for about 14 weeks to compare how the drug behaves in the body. The goal is to find which version works best for…

This large Phase 3 study tests whether a new weekly injection, NNC0487-0111, can reduce death and hospital stays in people with a common type of heart failure who also have obesity. About 5,600 participants will be randomly assigned to receive the drug or a placebo. The goal is t…

This study tests whether a probiotic called Akkermansia muciniphila, given as a capsule, can help overweight or obese adults lose weight and improve their metabolism. About 76 participants will take either the probiotic or a placebo for a period, while following a low-carb diet. …

This early study will test whether adding a new drug (CS0159) to a standard diabetes medication (semaglutide) can help people with fatty liver disease, obesity, and type 2 diabetes lose weight and improve their health. About 30 adults will take the combination or a placebo for 12…

This study tests whether setmelanotide can help a single patient with pseudohypoparathyroidism type 1a (a rare genetic disorder) lose weight. The patient will take the drug for 6 months, and researchers will measure weight loss, body fat, and blood sugar levels. The goal is to se…

This early study tests if injecting a person's own fat-derived stem cells into the upper intestine is safe and can improve blood sugar control in type 2 diabetes. The goal is to help the body respond better to insulin and manage the disease long-term. Fifteen adults with type 2 d…

This study tests a new drug called IBI362 in people with mild to moderate high blood pressure who are also overweight or obese and not taking blood pressure medication. The goal is to see if the drug can lower blood pressure and help with weight loss compared to a placebo. About …

This study tests whether tracking only high-calorie, low-nutrition foods (simplified approach) works as well as tracking all foods and calories for weight loss. About 328 adults with overweight or obesity will use a digital program for 12 months. The goal is to see if the simpler…

This early-stage study tests two versions of the medicine cagrilintide in 234 adults with overweight or obesity (BMI 27-35). Participants receive either version D or version B by chance, and researchers compare how the drug behaves in the body over about 6 months. The goal is to …

This study tests whether two experimental drugs, macupatide and eloralintide, can help people with obesity or overweight lose weight safely. About 400 adults who do not have type 2 diabetes will take the drugs alone, together, or a placebo for around 64 weeks. The main goal is to…

This study tests a procedure called endoscopic sleeve gastroplasty (ESG) that reduces stomach size using a flexible tube through the mouth, avoiding traditional surgery. It involves 300 adults with obesity who have not succeeded with diet, exercise, or medication. The main goal i…

This study looks at how exercise and a diet rich in fruits and vegetables affect the heart and metabolic health of teenagers with obesity. About 120 teens aged 13-17 will be placed into one of four groups: standard care, exercise only, diet only, or both exercise and diet. Over 1…

This study looks at how two weight-loss surgeries—sleeve gastrectomy and gastric bypass—affect acid reflux in people with obesity. About 128 adults with mild to moderate reflux will be randomly assigned to one surgery and monitored before and after. The goal is to see which surge…

This study tests a new medicine, CagriSema, to help people with overweight or obesity lose weight. About 1,400 adults will receive either CagriSema or a placebo injection for one year. The study compares two different injection devices to see if they work the same way.

This study tests if virtual, culturally tailored classes on healthy eating and physical activity can help Puerto Rican men lose at least 5% of their body weight. Forty-eight men over age 35 with a BMI of 25 or higher will join either the lifestyle program or a general health grou…

This study tests a weekly oral medication called ecnoglutide (VRB-101) to see if it can help people with obesity or overweight maintain their body weight. Participants must have already been on weekly injections of similar drugs for at least 6 months. The goal is to find the best…

This study looks at whether adding pork protein to the diet helps middle-aged women with overweight or obesity who are taking GLP-1 medications (like Ozempic or Wegovy). Over 12 weeks, 75 women will eat protein-rich pork products daily while continuing their medication. Researche…

This study tests whether a natural dietary fiber called oligofructose (found in onions, garlic, and bananas) can help improve blood sugar control, reduce inflammation, and support healthy gut bacteria in adults with type 2 diabetes. 100 Saudi adults (50 with diabetes and 50 witho…

This study will test the safety and effectiveness of the drug tirzepatide (Spartina) for weight loss in 15 adults with chronic kidney failure who also have diabetes or a BMI over 27. The goal is to see if this medication can help manage weight and blood sugar while avoiding side …

This study compares a minimally invasive procedure called POSE2.0, which uses sutures to reshape the stomach without cuts, combined with a moderate diet and exercise program, to diet and exercise alone. About 186 adults with obesity who have not succeeded with non-surgical weight…

This study looks at how well the drug tirzepatide works for weight loss and blood sugar control in everyday medical practice in Paraguay. It will include 160 adults: 80 with obesity but no diabetes, and 80 with type 2 diabetes (with or without obesity). All participants will take…

This early-stage study tests whether a new drug called NNC0113-5840 is safe for people with overweight or obesity. About 48 adults will receive either the drug or a placebo by chance. The main goal is to check for side effects and how the drug moves through the body.

This study tests whether taking a supplement (alpha-lipoic acid) with a drug (mirabegron) can improve how the body handles sugar and insulin in people with obesity. About 60 adults aged 18-65 with a BMI between 30 and 45 will take the combo or a placebo for 4 weeks. The goal is t…

This study tests two experimental drugs, PF-08653945 and PF-08653944, given alone or together, to help adults with overweight or obesity lose weight. About 872 participants will receive either the drugs or a placebo. The main goal is to see how much weight they lose and if the dr…

This study looks at whether a GLP-1 RA drug (used for diabetes and weight loss) can improve fat levels in the liver and blood of people with MASLD (fatty liver disease). About 30 adults with MASLD, diabetes, and obesity will take the drug and have liver biopsies and blood tests t…

This study tests whether vericiguat, a drug that boosts a natural signaling molecule called cGMP, can improve how the body uses energy and responds to insulin. It involves 200 Black adults with obesity and insulin resistance. Over 12 weeks, participants will receive either verici…

This study tests whether a once-daily oral cannabis pill can help people with obesity lose weight. Researchers will compare weight changes in 40 adults who take either the cannabis pill or a placebo. The goal is to see if this approach is effective and safe for weight management.

This study tests a new weekly injection, NNC0487-0111, against the approved drug semaglutide in 1000 adults with overweight or obesity and type 2 diabetes. Participants will receive two weekly shots (one active, one placebo) for about a year. The main goal is to see how much weig…

This study tests a new device called the Trans-Duodenal Barrier, a temporary implant placed in the upper small intestine for 6 months. It aims to lower blood sugar (HbA1c) and help with weight loss in adults with type 2 diabetes and obesity. Researchers will also check if it impr…

This study tests whether disulfiram, a drug already approved for alcohol use disorder, can safely reduce joint inflammation in people with rheumatoid arthritis who are also overweight or obese. Twenty adults with active arthritis despite standard treatment will receive either dis…

This study will check how safe and effective the drug tirzepatide is for 300 adults with obesity or overweight plus related health problems like type 2 diabetes. Participants will take the medicine as part of their regular care and be followed for 12 months. The main goal is to t…

The ROOT study tests a personalized nutrition program for pregnant women. By analyzing genes and nutrients, the program creates custom diet plans to reduce risks of preterm birth, preeclampsia, and gestational diabetes. The study will enroll 500 women in North Carolina and compar…

This study looks at whether brief, intense stair-climbing sessions, called 'exercise snacks,' can improve blood vessel function and body composition in overweight adults aged 18-35. Sixty participants will be split into four groups, including a no-exercise control group, for 6-8 …

This study looks at whether a TAP block—a type of nerve block given during surgery—can help the stomach and intestines work better after laparoscopic sleeve gastrectomy (weight-loss surgery). About 60 adults having this surgery will either get the block or not, and their recovery…

This study tests whether a non-invasive nerve stimulation device placed on the ear can help men with central obesity (belly fat) lose inches and reduce inflammation. Sixty men aged 25-35 with a BMI of 30 or higher will receive the treatment. The goal is to see if this approach ca…

This study aims to find the best combination of four dietary strategies—limiting high-calorie foods, eating within a set time window, increasing protein, and increasing fiber—for weight loss in adults with overweight or obesity. Over 12 weeks, 208 participants will track their we…

This early-stage study tests a new medicine, NNC0497-0040, given as a weekly shot. It will include healthy people, those who are overweight or obese, and people with type 1 diabetes who are also overweight. The main goal is to check if the drug is safe and tolerable, and how the …

This study tests if an experimental drug called BIO101 can help prevent muscle strength loss in people taking the weight-loss medication semaglutide. About 164 obese or overweight adults will take either BIO101 or a placebo pill twice daily for 21 weeks, along with semaglutide an…

This study tests whether a flexible, symptom-guided dosing plan for tirzepatide can reduce nausea and vomiting in adults with obesity who do not have diabetes. About 68 participants will be randomly assigned to either the standard dosing schedule or a flexible approach that allow…

This study tests whether a mobile app can help obese children aged 8-10 improve their eating attitudes, awareness, and confidence in making healthy food choices. About 52 children and their parents will use the app and complete surveys. The goal is to support healthier habits, no…

This study looks at whether using a device that strengthens breathing muscles can improve lung function, exercise ability, and pain in adults with obesity and long-term low back pain. About 48 people will either do aerobic exercise plus the breathing trainer or just exercise alon…

This study compares two ways of placing stitches in the stomach to help people lose weight. Ten adults with obesity will get one of two patterns using a device called Endomina. The goal is to see which pattern leads to more weight loss and fewer side effects over a year.

This study tests two different medicines (dexmedetomidine and low-dose ketamine) to see which one works better for pain control after weight-loss surgery. 90 adults will be randomly assigned to receive one of these medicines or a placebo during surgery. The goal is to find a safe…

This study tests a 6-session group skills program for people with obesity. The program teaches participants to notice and respond to body signals like hunger and emotions, which may help with emotional eating. Ten adults from an NHS weight management service will take part, and t…

This study looks at how obesity is linked to oral health problems like gum disease and cavities. Researchers will follow 400 adults who are getting weight-loss treatment (diet or surgery) and check their mouth health over 18 months. The goal is to see if losing weight improves de…

This study looks at how to help VA medical centers better serve women Veterans, especially those in midlife. Researchers will test two different strategies to get more women involved in programs for heart health, weight management, and stress. The study involves 18 VA sites and f…

This study looks at whether very obese patients have more breathing-tube problems during emergency care. Researchers will compare two groups—morbidly obese and super obese—to see if higher body weight leads to more complications like low oxygen. The goal is to better understand r…

This observational study looks at adults with obesity who are already planning weight loss surgery. Researchers will use heart CT scans and ultrasounds before and six months after surgery to see if fat inside the heart muscle decreases and if the heart's ability to relax improves…

This study will collect health information and samples (blood, saliva, urine, stool) from up to 1,000 people aged 8 to 65 who are overweight, have high blood sugar, or metabolic problems. Researchers want to learn how diabetes and obesity develop and change over many years. Parti…

This study looks at whether taking a calcium butyrate supplement for 4 weeks can improve how immune cells (monocytes) work and change gut bacteria in adults with obesity. Butyrate is a natural substance made by healthy gut bacteria, but people with obesity often have less of it. …

This pilot study looks at whether a new program can help people manage their weight after they stop taking anti-obesity medications like Wegovy or Ozempic. Researchers want to see if the program is easy to run and acceptable to patients. About 214 adults with obesity will either …

This study looks at how weight-loss surgery affects the way people sense and interpret signals from their own bodies, like hunger and fullness. Researchers will follow 300 adults with severe obesity before and up to two years after surgery. The goal is to understand how these cha…

This study checks if a computer program called Soma can correctly measure muscle and fat from CT scans. Researchers will compare Soma's results to measurements made by three expert radiologists using 200 CT scans from public databases. The goal is to see if the software is accura…

This study follows 400 children ages 5 to 7, some with obesity and some of normal weight, to see what factors like genes, hormones, diet, and chemical exposures affect when puberty starts. Children will have check-ups every 6 months until age 12, including blood tests, physical e…

This early-stage study is testing a new medicine for overweight and obesity in 35 adults with and without liver problems. The goal is to see how the drug moves through the body and if it is safe. Results will help guide future use in people with reduced liver function.

This study tests a free online platform called Precare for people waiting for bariatric surgery. The goal is to see if it helps patients feel more ready and reduces the number who cancel surgery. About 1,050 adults on the waiting list at one hospital in Quebec will use the platfo…

This study looks at how the weight-loss drug semaglutide changes the gut bacteria in 40 adults with obesity. Participants will take semaglutide for 12 weeks, and researchers will analyze their stool samples to see how the bacteria in their intestines shift. The goal is to better …

This study looks at how the body makes new sugar from fat and blood molecules in people with and without type 2 diabetes. Researchers will give special tracers and take blood samples to track this process. The goal is to find new ways to lower blood sugar more effectively. About …

This study looks at how body fat and muscle affect the way anesthetic drugs work in overweight and obese patients. Researchers will measure body composition and track drug levels and complications during surgery. About 2,100 adults aged 18-65 will take part. No new treatments are…

This study looks at how two different exercise programs—moderate steady walking versus short bursts of brisk walking—affect heart health and inflammation in women with obesity and high blood pressure. Researchers will measure a protein called Sestrin-2, which may help control inf…

This study is testing a new AI-powered tool called AIManage that helps doctors and patients manage medications for diabetes and obesity. The tool will provide guidance on adjusting doses. The study involves 16 participants and will first gather feedback on how useful and easy the…

This study looks at how tirzepatide, a diabetes and weight-loss drug, helps people with obesity and a type of heart failure called HFpEF. Researchers will measure blood volume and body fat in 50 patients over 15 months to understand why the drug improves symptoms. The goal is to …

This study looks at the gut bacteria of 270 adults in New Caledonia to understand how they relate to obesity and type 2 diabetes. Participants include healthy people, those with obesity, and those with both obesity and diabetes. Researchers will analyze stool samples to find link…

This study looks at how cartoon characters and warning labels on food packages influence what Colombian children aged 12 to 17 think about the product and whether they want to buy it. About 1,960 kids will take an online survey where they see different package designs. The goal i…

This study looks at how body fat, muscle mass, and breathing endurance are connected in 100 adults with obesity who also have a restrictive breathing pattern. Participants will have their body composition measured, take breathing tests, and do a six-minute walk test. The goal is …

This study compares two devices that measure muscle relaxation during anesthesia in 30 obese adults having weight-loss surgery. One device uses motion (acceleromyography) and the other uses electrical signals (electromyography). The goal is to see which is more accurate and easie…

This study looks at how changing insulin levels affects the liver's production of sugar and fat in people with insulin resistance and fatty liver disease. About 36 adults with overweight or obesity will undergo two procedures where insulin is either kept high or lowered by half. …

This study looks at whether smartphone addiction is connected to obesity and physical fitness in young adults. Researchers will measure walking ability and body shape in 212 people aged 18 to 25 who use their phones over 5 hours daily. No treatment is given—this is an observation…

This study looks at obese adults who use a CPAP machine for sleep apnea to see if they still have low oxygen levels at night. Researchers will use a special skin sensor to measure breathing. The goal is to find out how common this hidden breathing problem is in this group.

This study will test a mobile app designed to help adults taking GLP-1 medications for obesity or type 2 diabetes improve their eating habits. Fifty participants will use the app for 6 weeks to track their diet and learn about nutrition. The goal is to see if the app is helpful, …

This study looks back at medical records of 500-800 children aged 2-18 who had severe obesity starting before age 5 and already received NHS genetic tests. Researchers want to learn how often these tests find a genetic cause and which symptoms (like developmental delays or eating…

This early-stage study looks at how a new drug called HDM1005 affects stomach emptying and interacts with common medications like metformin, atorvastatin, warfarin, and digoxin in 42 overweight or obese Chinese adults aged 18-45. The goal is to understand how the body processes t…

This study is creating a large collection of health information and blood samples from 25,000 adults with obesity. Researchers will use this data to learn more about obesity, its related health problems, and what treatments work best. The goal is to improve care and prevention st…

This study looks at how children's eating behaviors, like eating quickly or eating large portions, are linked to brain activity and body fat. Researchers will follow 420 children aged 7-9 for one year, using brain scans, meal observations, and questionnaires. The goal is to under…

This study looks at how body roundness (a measure of fat distribution) relates to lung function and exercise ability in 120 adults with obesity. Participants will have their breathing muscles, lung capacity, and walking endurance tested. The goal is to see if body roundness can h…

This study looks at how different Enneagram personality types are linked to eating habits, emotional eating, and overall well-being in 250 adults with obesity. Participants will fill out questionnaires about their personality, eating behaviors, and spirituality. The goal is to be…

This study looks at how a healthy, calorie-controlled diet (the DASH diet) affects weight and gut bacteria compared to a typical American diet. Twenty-eight Black and White women with obesity will eat study-provided meals for 4 weeks. Researchers will collect stool samples to see…

This study looks at whether certain autoantibodies (proteins that attack the body's own cells) are present in people with obesity and if they are linked to how severe the obesity is. Researchers will also check if these antibodies are connected to obesity-related health problems …

This study looks at how genetics and what we eat might cause brain inflammation that leads to obesity. Researchers will study 110 identical twins who eat differently to see if their brains show signs of inflammation. They will also test how the brain responds to overfeeding and u…

This study aims to find the best ways to help people with obesity enroll in digital weight-loss programs offered at community health centers. Over 5,000 adults with a BMI of 30 or higher will take part. Researchers will test different strategies, like clinic reminders and patient…

This study will use ultrasound to take pictures of the stomach in 10 patients who are having weight-loss surgery. The goal is to learn how the stomach looks before and after the operation. Patients will be asleep during the imaging, so there is little discomfort.

This study looks at how fat tissue in the upper body reacts after a meal, comparing normal-weight people to those with obesity. Researchers will measure blood flow and tiny particles called exosomes released by fat cells. The goal is to better understand how fat tissue works, not…

This early-stage study tests two similar experimental injections for obesity in 40 healthy adults aged 19 to 65. Each person receives both injections at different times to compare safety and how the drug moves through the body. The goal is not to treat obesity but to gather safet…

This study will check stress, sleep quality, and bad breath in 110 adults who are getting ready for weight-loss surgery. Participants will fill out questionnaires and use a small device to measure breath. The goal is to learn more about these issues so doctors can offer better su…

This study tests whether a bedside lung ultrasound can help doctors see how well collapsed lung areas reopen in obese patients on breathing machines. About 45 adults with a BMI of 33 or higher will be scanned before, during, and after a standard lung-opening procedure. The goal i…

This study will compare different ways to measure body changes in 20 adults with severe obesity who are scheduled for weight-loss surgery. Researchers want to see if advanced tools like MRI and 3D body scans give more useful information than simple scales and tape measures. The g…