OBESITY

This study tested a weekly injection of semaglutide (2.4 mg) in 201 teenagers ages 12 to 17 with overweight or obesity. Participants received either the drug or a placebo for about 15 months, along with lifestyle counseling. The main goal was to see how much their body mass index…

This study tested a new medicine called CagriSema, which combines two drugs (cagrilintide and semaglutide), to help people with excess weight lose weight. About 300 adults with a BMI of 30 or higher (or 27 with related health issues) received either CagriSema or a dummy shot once…

This study tested a new magnetic system (MagDI) that creates a connection in the small intestine to help with weight loss and type 2 diabetes. 27 adults with obesity (BMI 30-50) and some with diabetes took part. The goal was to see if the device could be placed safely and work as…

This study compared daily fasting to traditional calorie restriction for weight loss in 115 obese adults. Participants followed either a fasting schedule or reduced their daily calories for 12 weeks. The goal was to see if fasting is a practical alternative for people who struggl…

This early-stage study tested a new medicine, NNC0519-0130, given as a weekly shot. The goal was to check its safety and how it affects body weight and blood sugar in 82 adults with obesity or type 2 diabetes. Participants received either the drug or a placebo for up to 37 weeks.…

This study tested a mobile app designed to help small corner stores in low-income Baltimore neighborhoods buy and sell more healthy foods and drinks. Researchers worked with 38 stores and about 310 regular customers to see if the app improved the availability and sales of healthi…

This study tested a new way to help adults with obesity lose weight using personalized health planning in group medical visits. Eleven motivated adults aged 30 to 60 with a BMI between 35 and 50 took part. The approach tracked weight, blood pressure, waist size, and mood changes …

This study tested a newer, simpler weight loss surgery called SADI-S against a standard, more complex surgery (BPD-DS) in 62 adults with severe obesity. The goal was to see if SADI-S is safer and just as effective for weight loss and related health problems like diabetes. Researc…

This study looked at whether a low-carb, high-fat (ketogenic) diet with fewer calories can reduce harmful substances in the blood and improve insulin function in adults with prediabetes and obesity. 90 participants aged 18-40 were split into three groups: one on a keto diet, one …

This study looked at whether adding vitamin D supplements to a healthy diet and exercise program could improve blood vessel function in obese teenagers. 49 teens participated over 3 months. The main goal was to see if the vitamin helped the arteries relax and work better, which i…

This study looked at whether adding a new drug, mibavademab, to the existing weight-loss drug tirzepatide helps adults with obesity lose more weight than tirzepatide alone. About 392 participants took part over 74 weeks. The goal was to see if the combination leads to greater wei…

This study tested whether a capsule containing pasteurized Akkermansia muciniphila bacteria could help overweight or obese adults lose weight and improve metabolism. Sixty-one participants took either the probiotic or a placebo for a period, while following a low-carb diet. The g…

This study looked at whether combining digital tools (like an app for tracking health and communicating with doctors) with regular in-person visits works as well as standard care for children and teens with obesity. About 100 families in Sweden took part. The goal was to see if t…

This early-stage study tested a single dose of the investigational drug eloralintide in 30 Chinese adults who are overweight or have obesity. The main goal was to check for side effects and see how the drug moves through the body. Participants received either the drug or a placeb…

This study looked at whether eating only during a set window each day (time-restricted eating) and doing short, intense workouts (high-intensity interval training) can help people with metabolic syndrome. 200 overweight or obese adults with metabolic syndrome took part for 16 wee…

This study tested whether taking a probiotic called Hafnia alvei for 90 days after gastric bypass surgery helps people lose more weight and control their blood sugar better. 49 adults who had the surgery took either the probiotic or a placebo. Researchers tracked their weight, bl…

This study looked at 100 people who were still obese 6 months after weight-loss surgery. Researchers wanted to see if starting the drug liraglutide early helps with more weight loss. The goal is to find the best time to add this medication for better results.

This study tested a new medicine called survodutide to help people with obesity lose weight. About 274 Japanese adults with a high body mass index and weight-related health problems took part. Participants received either the drug or a placebo injection once a week for 76 weeks, …

This study tested whether combining two minimally invasive procedures—Hybrid Argon Plasma Coagulation (HAPC) and Endoscopic Sleeve Gastroplasty (ESG)—is safer and more effective for weight loss than ESG alone. 45 adults with obesity (BMI 30-40) who had not succeeded with non-surg…

This study tested a 6-month, peer-led weight loss program for 116 older African American women with obesity. The program aimed to help them lose weight and improve physical function through community support. Results could show how a low-cost, group-based approach can reduce heal…

This study looked at whether community health workers (CHWs) can improve health outcomes for people with chronic conditions like diabetes, high blood pressure, and obesity. Over 10 months, 202 low-income adults from specific zip codes received either CHW support plus standard car…

This study tested whether a mental technique called WOOP (Wish, Outcome, Obstacle, Plan) could help veterans with obesity lose more weight when added to the VA's telephone-based MOVE! program. About 405 veterans took part. The goal was to see if combining WOOP with standard weigh…

This study looked at whether losing weight before in vitro fertilization (IVF) helps overweight and obese women have a live birth. Researchers followed 197 women aged 20-36 who were having their first IVF treatment. Some women followed a diet and exercise program for 3 months bef…

This study tested a weight management program designed specifically for veterans with PTSD who are overweight or obese. The program added extra support to standard PTSD care to help overcome barriers like stress and low motivation. 174 veterans took part, and researchers measured…

This study tested if standing on a vibrating platform (whole-body vibration) could help overweight and obese university students lose weight and improve body composition. Thirty-two students with a BMI of 25 or higher took part. Researchers measured changes in BMI, waist size, an…

This study looked at whether taking spirulina supplements along with reducing calories can help men with obesity lose weight and improve cholesterol, blood sugar, and stress markers. Thirty-five men took spirulina or a placebo for 30 days. The goal was to see if this combination …

This study looked at using deep brain stimulation (DBS) in the lateral hypothalamic area to help with severe obesity. Three people who already had DBS electrodes placed in a previous study took part. The goal was to find the best stimulation settings to change their metabolic rat…

This study tested a new magnetic system that creates a connection between two parts of the small intestine, bypassing a section to help with weight loss and blood sugar control. Nine adults with obesity and type 2 diabetes received the procedure. The goal was to see if the magnet…

This study looked at whether weight-loss surgery (vertical sleeve gastrectomy) can improve diabetes and kidney health in teens aged 12-21 with type 2 diabetes. Researchers measured how well the pancreas and kidneys worked before and after surgery. The goal was to see if surgery c…

This study tested whether the drug tirzepatide helps people with obesity or overweight maintain weight loss they already achieved. About 441 adults took either tirzepatide or a placebo once a week for up to 60 weeks. The goal was to see if the drug could help them keep off at lea…

This study tested a smartphone app called ANíMATE designed to help people with obesity better manage their weight and health habits. 36 adults with a BMI between 30 and 40 used the app for 16 weeks alongside standard care. The goal was to see if the app helped them lose more weig…

This study tested whether a virtual weight management program combined with a continuous glucose monitor could help adults with type 2 diabetes lower their blood sugar levels. 152 overweight or obese adults with type 2 diabetes participated. The program was delivered through a di…

This study tested a drug called enobosarm in 168 adults aged 60 and older who were already taking GLP-1 weight-loss medications. The goal was to see if enobosarm could help prevent muscle loss, a common side effect of these weight-loss drugs. Participants received enobosarm or a …

This study looked at whether a class of diabetes drugs called GLP-1 receptor agonists can reduce fat stored in and around the heart, and improve heart function, in 44 obese adults with type 2 diabetes. Participants received the drug and were monitored using heart MRI scans. The g…

This study tested whether a combination of two medications (naltrexone and bupropion) can help people with binge-eating disorder and obesity reduce their binge-eating episodes and lose weight. Participants were adults aged 18 to 64 who met criteria for binge-eating disorder and h…

This early-stage trial tested an investigational injection called PB-119 in 32 Chinese adults with obesity. The main goal was to check safety and how the drug moves through the body, while also measuring weight loss. Participants received either the drug or a placebo, and the stu…

This study looked at whether gastric bypass surgery or the best available medical treatment is more effective for obese patients with poorly controlled type 2 diabetes. Researchers tracked 66 participants to compare death rates, weight loss, blood sugar control, quality of life, …

This study tested whether a diet high in boron (a natural mineral) or a Mediterranean-style diet could improve health in 40 obese adults. Over 4 weeks, researchers measured changes in body mass index, gut bacteria, appetite hormones, and heart-related blood markers. The goal was …

This study tested whether using technology (like apps or video calls) to check in with doctors from home helps obese teenagers lose weight better than regular in-person visits. 91 teens aged 11-17 took part. The main goal was to see if the tech-based approach led to a bigger drop…

This study tested a once-weekly injection of semaglutide (2.4 mg) to help people with overweight or obesity lose weight. About 375 adults took part, some receiving the drug and others a placebo, along with lifestyle advice. The main goal was to see how much weight they lost over …

This study looked at whether a three-month supervised exercise program can help men with type 2 diabetes, prediabetes, or obesity improve their blood sugar, body composition, and fitness. Three hundred sedentary men aged 35-65 took part in regular training sessions at a fitness c…

This study looked at whether adding a whey protein supplement to a reduced-calorie diet helps overweight and obese adults lose more weight and improve their metabolism. A total of 110 people aged 25 to 35 with a BMI of 24 or higher took part. The results will help guide better di…

This study tested a 24-week program that combines WeightWatchers behavioral support with medical weight management (including prescription drugs like Wegovy or Mounjaro). 180 adults with obesity or overweight plus related conditions took part. The goal was to see how much weight …

This study tested whether a high-intensity medical weight loss program, supported by a digital platform, could help people with type 2 diabetes achieve remission. 64 participants with recent diabetes diagnosis and obesity were enrolled. The program used tailored treatment plans, …

This study tested whether an 8-week circuit exercise program (combining aerobic and resistance moves) could improve inflammation markers in 22 overweight women aged 20-30. Participants exercised four times a week at moderate-to-high intensity. Results showed the program increased…

This study looked at whether eating only during a set window each day (time-restricted eating) combined with supervised exercise can reduce liver fat and improve heart health in adults with obesity. 187 people took part in a 12-week program. The goal was to see if combining these…

This early-stage study tested an oral tablet called ecnoglutide in 87 healthy adults to see if it is safe and how the body processes it. The drug is designed to help manage type 2 diabetes and obesity by mimicking a natural hormone that controls blood sugar and appetite. Particip…

This study looked at whether taking fish oil supplements while exercising can lower inflammation linked to obesity. 129 overweight or obese adults with high triglycerides and prediabetes took part. Researchers measured changes in blood markers of inflammation, cholesterol, blood …

This study tested whether a probiotic called Lactobacillus gasseri can help overweight women manage their weight and balance sex hormones. 110 women took part. The main focus was on changes in belly fat and estrogen levels. Results may offer a natural way to support weight contro…

This study looked at whether having a spouse, partner, or other adult living with them helps Veterans lose more weight in a VA weight management program. About 300 Veterans with obesity took part, and their weight was tracked for 72 weeks. The goal was to see if social support fr…

This study tested a new magnetic system that creates a shortcut in the digestive tract to help adults with obesity and type 2 diabetes lose weight and control blood sugar. Fifteen participants received the procedure to see if the connection could be made safely and effectively. T…

This study tested whether a drug called bromocriptine, which boosts dopamine in the brain, can help people with obesity lose weight. The key twist: the drug's effect may depend on a person's genetic makeup, specifically a gene called FTO. 120 participants took either bromocriptin…

This study looked at whether sharing digital self-monitoring data (like weight, activity, and food logs) with a friend or family member helps adults with overweight or obesity lose more weight over 24 months. 322 adults used digital tools to track their progress daily. The goal w…

This study tested whether a 6-week mindfulness program could help teens at risk for type 2 diabetes who also have depression. 120 teens aged 12-17 took part. The goal was to see if the program was practical and well-received, and if it could lower depression and insulin resistanc…

This study followed 1581 adults aged 18-65 who had bariatric surgery (gastric bypass or sleeve gastrectomy) to see how it affects metabolic syndrome over 10 years. Researchers tracked weight, blood pressure, blood sugar, and cholesterol levels. The goal was to understand if surge…

This study looked at over 285,000 people with overweight or obesity to see if the weekly injection semaglutide (used for weight loss and diabetes) lowers the risk of heart problems like heart attacks, strokes, and death. Researchers analyzed medical records from 2016 to 2024. The…

This study looked at whether limiting when you eat each day can help adults who have recently lost weight keep it off. 29 adults who had lost at least 5% of their body weight were asked to eat all their meals within either a 6-hour or a 10-hour window each day. The study measured…

This study tested an experimental drug called CT-868 in 103 overweight or obese adults with type 2 diabetes. The goal was to see if the drug could lower blood sugar levels and help with weight loss over 26 weeks. Participants received either the drug or a placebo, and researchers…

This study tested two ways to help people keep weight off after losing at least 5% of their body weight. One group got monthly phone calls, while the other got calls only when a computer algorithm predicted they were at high risk of regaining weight. The goal was to see which app…

This early-stage study tested a new drug called LY3532226 in 132 people with obesity to see if it is safe and how the body processes it. Participants received weekly or monthly doses for up to 20 weeks. The goal was to check for side effects and measure drug levels in the blood, …

This early-stage study tested an experimental drug called LY3437943 against a placebo in 85 adults with obesity. The goal was to see how the drug affects calorie intake, energy metabolism, and appetite while participants followed a calorie-restricted diet. The study lasted up to …

This study looked at how semaglutide, a weekly injection for weight loss, affects appetite, eating habits, and food preferences in adults with obesity. 120 participants received either the drug or a placebo, along with diet and exercise advice, for 72 weeks. The goal was to measu…

This early-stage study tested a new drug called AMG 133 in 110 adults with obesity. The main goal was to see if the drug is safe and how the body processes it. Participants received either the drug or a placebo, and researchers tracked side effects and drug levels in the blood.

This study compared two types of gastric bypass surgery for obesity to see which one causes fewer problems like acid reflux and stomach ulcers. 200 adults with a BMI between 30 and 50 took part. The goal was to find out which surgical method leads to better long-term outcomes.

This study looked at whether losing fat through a controlled diet helps obese older adults get more out of exercise. 180 sedentary seniors with a BMI of 30-35 took part. Researchers measured improvements in heart fitness and walking endurance to see if combining calorie restricti…

This study looked at what works best for keeping weight off after stopping popular GLP-1 drugs like Wegovy or Zepbound. About 226 adults who had lost at least 15% of their body weight on these medications were followed for 12 weeks after stopping. The goal was to see which step-d…

This early-stage study tested whether adding a new drug (LY3841136) to an existing weight-loss medication (tirzepatide) is safe and tolerable in overweight and obese adults. A total of 96 healthy volunteers with a BMI between 27 and 45 took part. The study lasted up to 42 weeks a…

This study tested two weight loss programs in 223 adults with overweight or obesity. One group followed a fixed daily calorie limit, while the other varied their calorie intake day-to-day. The goal was to see which approach leads to more weight loss.

This study tested whether a weight-loss medication (phentermine/topiramate) can help shrink kidney stones and improve health in obese adults with uric acid stones and type 2 diabetes or pre-diabetes. Nineteen participants were randomly assigned to either the drug or standard care…

This study tested a 5-week hospital program combining exercise, nutrition advice, and education for adults with Prader-Willi syndrome. The goal was to help patients stabilize or lower their body mass index (BMI) for 6 months after leaving the hospital. 128 participants were rando…

This study tested a new daily injection called LY3549492 to help adults with obesity or overweight lose weight. About 288 participants received either the drug or a placebo for roughly one year. The main goal was to see how much weight people lost and how safe the treatment was.

This study tested a workplace weight loss program for hospital employees with obesity (BMI 27 or higher). Over 500 participants used the So99 app to track healthy eating, exercise, and teamwork. The main goal was to see how much weight they lost from the start of the program.

This study tested a high dose (7.2 mg) of semaglutide, a once-weekly injection, in 512 adults with obesity and type 2 diabetes. Participants received either the high dose, a lower dose, or a placebo, along with lifestyle counseling. The main goals were to measure weight loss and …

This study tested whether a personalized lifestyle program could help adults with insulin resistance, obesity, diabetes, or related conditions improve their metabolic health. Forty participants first received either nutrition or exercise counseling. Those who didn't improve after…

This early-stage study tested a single injection of a new drug called AMG 133 (Maridebart Cafraglutide) in 20 Chinese adults who are overweight or have obesity. The main goal was to see how the drug moves through the body and to check for any safety issues. Participants were heal…

This study looked at whether two different low-calorie Mediterranean diet plans, combined with moderate aerobic exercise, could improve liver health, gut function, and metabolic risk in 36 adults with obesity and non-alcoholic fatty liver disease (NAFLD). Participants followed on…

This study tested a new medication called aleniglipron (GSBR-1290) to help people with obesity or overweight lose weight. 85 adults took different doses of the drug or a placebo for 44 weeks, along with diet and exercise. The main goals were to check safety and side effects, and …

This study looked at whether a program of physical exercise combined with a daily supplement of leucine and arginine could help obese adults with metabolic syndrome lose body fat and improve their health. About 79 participants took part. The goal was to see if this approach could…

This study looked at three different weight loss strategies for adults with chronic spinal cord injury who are overweight. The goal was to find which approach—prepackaged meals, better self-monitoring, or a combined program—works best. 110 participants tried each method for 13 we…

This study tested an investigational injection called GZR18 in 340 Chinese adults with obesity or overweight. Participants received either the drug or a placebo, along with diet and exercise advice. The main goal was to see how much weight they lost after 30 weeks. The study is c…

This study looked at whether alternating between a day of fasting and a day of normal eating, combined with exercise, can reduce liver fat in people with non-alcoholic fatty liver disease (NAFLD). The trial included 80 obese adults who were not very active. Researchers measured c…

This study looked at whether eating strawberries can help improve cholesterol, blood sugar, and blood vessel function in overweight or obese adults at risk for heart disease and metabolic syndrome. 48 participants ate strawberries as part of their diet, and researchers measured c…

This study tested a new investigational medicine called CagriSema (a combination of two drugs) against tirzepatide, another weight-loss injection, in 809 adults with obesity. Participants received weekly injections under the skin for about one and a half years. The goal was to se…

This study tested a new medicine called petrelintide, given once a week, to help people with obesity or overweight (plus related health problems like high blood pressure) lose weight. About 493 adults took part, receiving either different doses of petrelintide or a placebo, along…

This study tested a new weekly injection called CagriSema (a mix of two medicines) to help people with overweight or obesity and type 2 diabetes lose weight. About 1,200 adults took part, receiving either CagriSema or a placebo for around 1.5 years. The main goals were to see how…

This study tested a weekly injection of semaglutide (2.4 mg) in 207 adults with obesity and prediabetes. Participants received either the drug or a placebo for 12 months, plus lifestyle advice. The goal was to see if the drug could help them lose weight and return to normal blood…

This study looked at whether having a peer coach—someone like you who has lost weight—can help people with obesity lose more weight than trying on their own. 375 adults with a BMI between 30 and 50 took part. The program used phone calls and group sessions to support healthy eati…

This study tested whether a weight-loss drug (semaglutide) combined with a very low-calorie diet could help people with idiopathic intracranial hypertension (IIH), a condition where high brain pressure causes headaches and vision problems. 38 adults with new-onset IIH and obesity…

This study tested whether adding a weekly semaglutide injection to a reduced dose of insulin glargine works as well as a higher insulin dose alone for controlling blood sugar in people with type 2 diabetes and overweight. About 573 participants were followed for 11 months. The go…

This study tested a wellness coaching program called 'house chats' to help African American adults in Petersburg, Virginia, lose weight and improve their health. Twenty-two participants received coaching on physical activity, diet, and weight management. The goal was to see if th…

This study looked at whether using a non-invasive breathing mask (NIV) right after removing a breathing tube can prevent serious breathing problems in obese patients in the intensive care unit. About 1000 obese adults who needed a breathing tube for at least 6 hours took part. Th…

This study tested a culturally-tailored program that combines nutrition, exercise, and stress management to help African American women improve their heart health. 175 women with risk factors like high blood pressure or prediabetes took part. The goal was to see if the program co…

This study tested whether intermittent fasting (eating only during certain hours) helps people with obesity lose more weight than simply cutting calories every day. Over one year, 165 adults followed either approach with similar weekly calorie goals and support. The main goal was…

This study looked at whether taking aspirin twice a day (100 mg each time) works better than the usual once-a-day dose to prevent another heart attack, stroke, or urgent heart procedure in people with diabetes who have had a recent heart attack or unstable angina. About 2,500 par…

This study tested two medications, tirzepatide and semaglutide, to see which works better for weight loss in adults with obesity or overweight who also have related health problems like high blood pressure. About 751 people took part, and the trial lasted around 74 weeks. The mai…

This study tested a medicine called survodutide in 218 adults with overweight or obesity and a liver condition called NASH (fatty liver with inflammation). Participants received weekly injections of survodutide or a placebo for about a year, along with diet and exercise advice. T…

This study tested a lifestyle program for pregnant women with obesity to help them maintain weight and lose fat mass. About 100 women joined early in pregnancy and were randomly assigned to the program or usual care. Researchers measured weight, fat mass, and safety for both moth…

This study tested a daily oral semaglutide tablet (25 mg) in 307 adults with overweight or obesity to see how well it helps reduce body weight. Participants took the drug or a placebo for 64 weeks, followed by 7 weeks of follow-up. The main goals were percentage weight loss and t…

This early-stage study tested an investigational drug called XW003 in 48 Chinese teenagers with obesity. The main goal was to check safety and how the drug moves through the body, while also measuring weight changes. Participants received multiple doses of the drug or a placebo, …

This pilot study tested two health coaching strategies for Black adults with stage 1 obesity and conditions like high blood pressure, prediabetes, or high cholesterol. One strategy focused on weight loss, while the other focused on increasing physical activity without targeting w…

This study tested whether a personalized electronic program could help pregnant women with obesity gain a healthy amount of weight and reduce the need for delivery procedures like C-sections or forceps. Over 800 women participated, using an online tool to track weight and get adv…

This study compared a once-daily pill called orforglipron to insulin glargine in about 2,700 adults with type 2 diabetes who were also overweight or obese and had increased heart or kidney risk. The main goal was to see if orforglipron could delay or prevent major heart problems …

This study followed 262 adults with type 2 diabetes and obesity for up to 13 years to see if bariatric surgery or medical/lifestyle management works better over time. Researchers measured blood sugar levels and how many people achieved diabetes remission without needing medicatio…

This study tested a new medicine called survodutide (BI 456906) in 755 adults with overweight or obesity and type 2 diabetes. Participants received weekly injections of either the drug or a placebo for about 76 weeks, along with diet and exercise advice. The main goal was to see …

This study tested a once-weekly medicine called semaglutide in 115 adults with type 1 diabetes and obesity who already use an automated insulin pump. The goal was to see if adding semaglutide helps improve blood sugar control and reduce weight. Participants received either semagl…

This study looked at whether eating quinoa and buckwheat instead of rice or bulgur helps overweight adults lose weight and improve their gut health. 148 healthy adults aged 25-45 with a BMI between 25 and 35 took part. Researchers measured weight, blood sugar, cholesterol, and ch…

This study tested a 3-month remote program for people who regained at least 10% of their weight after sleeve gastrectomy. The program included support from a team of experts and motivational text messages. 100 participants were split into two groups: one received the remote progr…

This study tested a daily tablet called semaglutide to help people with overweight or obesity lose weight. 667 adults took either the real tablet or a dummy pill for 68 weeks, along with diet and exercise advice. The main goals were to see how much weight they lost and how many l…

This study looked at whether walking downstairs is a good exercise for women with obesity who don't exercise regularly. 24 women did stair walking twice a week for 8 weeks. Researchers measured changes in cholesterol, blood sugar, and body fat to see if this simple activity could…

This study tested a new, non-surgical procedure called Gastric Mucosal Ablation (GMA) to help people with obesity lose weight. The procedure uses a special tool to remove a thin layer of stomach tissue, which may affect hormones that control weight. Fifteen adults with a BMI betw…

This study tested whether taking sodium butyrate tablets for 12 weeks, along with a reduced-calorie diet, helps overweight or obese people lose more weight and improve blood sugar control compared to a placebo. The trial included 46 adults aged 30-70 with or without type 2 diabet…

This study tested a program where trained peer mentors (older students) helped 9th and 10th graders in Appalachian high schools become more physically active. The program was compared to a teacher-led version. The goal was to see if peer support could improve health behaviors lik…

This study tested whether a virtual coach (through MyChart) helps people with obesity lose weight before ventral hernia surgery. Researchers compared weight loss over six months between those using the coach and those receiving usual care. The goal was to see if better pre-surger…

This study tested a surgery that combines a sleeve gastrectomy (stomach reduction) with a rerouting of the small intestine to help people with obesity and type 2 diabetes lose weight and control blood sugar. 18 adults aged 19-65 with a BMI between 35 and 50 and stable diabetes to…

This study looked at a procedure called endoscopic sleeve gastroplasty to help people with obesity lose weight. 75 adults who had trouble losing weight with diet and exercise alone took part. The procedure reduces stomach size using a tube inserted through the mouth, and particip…

This study tested whether using behavioral economics (like rewards and reminders) can help adults from low-income backgrounds lose weight. 195 participants aged 18-75 with a BMI between 25-55 were enrolled. The main goal was to see how much weight they lost over the study period.

This study tested whether a daily tablet of semaglutide (50 mg) helps Chinese adults with overweight or obesity lose weight. About 200 participants took either the drug or a placebo for 44 weeks, along with receiving advice on diet and exercise. The main goals were to see how muc…

This study tested a drug called tesamorelin in 51 obese adults with nonalcoholic fatty liver disease (NAFLD). The drug aims to boost growth hormone levels, which may reduce liver fat and inflammation. Researchers measured liver fat with special scans and biopsies to see if the tr…

This study tested a medicine called survodutide (BI 456906) in 726 adults with overweight or obesity who do not have type 2 diabetes. Participants received weekly injections of either the drug or a placebo for about 76 weeks, along with diet and exercise advice. The main goals we…

This study tested a 12-month remote weight loss program for 696 veterans with obstructive sleep apnea and obesity. Participants watched videos, tracked food and activity, and had coaching calls. The goal was to improve sleep-related quality of life and reduce weight. The program …

This study tested if a 1-year text messaging program, with or without monthly calls from a community health worker, could help 316 public housing residents in Boston lose weight. Participants were split into three groups: text messages only, texts plus phone coaching, or a contro…

This study tested whether a medication (polyethylene glycol loxenatide) combined with a hormone-releasing IUD (LNG-IUS) can better treat atypical endometrial hyperplasia, a precancerous condition of the uterine lining. The 30 participants were women with obesity who wanted to pre…

This study tested whether an online family skills training program is practical and well-liked by Black adults trying to lose weight. 21 participants joined with a family member and attended online sessions. The goal was to see if this approach could support healthier eating and …

This study tested whether adding a weight-loss drug (tirzepatide) to a standard psoriatic arthritis treatment (ixekizumab) helps people with both active psoriatic arthritis and obesity or overweight. About 279 adults took part, receiving either ixekizumab alone or both drugs toge…

This study tested whether a health program delivered through the WeChat app could help children with autism (ages 8-12) manage their weight. 276 families in China were split into three groups: usual care, a 16-week WeChat program, or the same program plus weekly group video chats…

This study tested whether providing free, culturally tailored healthy meals (14 per week for 10 weeks) plus weekly group support sessions could help Black adults with high blood pressure, type 2 diabetes, obesity, or metabolic syndrome. 75 participants were split into three group…

This study tested two 12-month behavioral weight-management programs in 321 adults with obesity and high blood pressure. Participants were followed for 3 years to see if they could lose at least 7% of their starting weight and keep off most of it. The goal was to find better ways…

This study tested three different doses of a new drug, AMG 133, against a placebo in 592 adults with overweight or obesity. Some participants also had type 2 diabetes. The main goal was to see how much weight people lost after 52 weeks of treatment. The drug aims to help control …

This study compared two types of weight-loss surgery—Omega Loop Bypass and Roux-en-Y Gastric Bypass—in 256 adults with severe obesity. The goal was to see which surgery works better for weight loss and has fewer complications. Both surgeries aim to help people lose weight and imp…

This study tested a new medicine called survodutide in 307 Chinese adults with obesity or overweight who also had weight-related health problems. Participants received weekly injections of either survodutide or a placebo for about 19 months. The main goals were to see how much we…

This study tested a new weekly injection called CT-388 to help people with obesity or overweight lose weight. About 469 adults took part, receiving either a low, middle, or high dose of the drug or a placebo for 48 weeks. The main goal was to see how much weight they lost and if …

This study tested how well semaglutide helps people with obesity lose weight compared to four other approved weight loss medications. About 500 adults from three US employers took part. The goal was to see if semaglutide leads to at least 10% weight loss and improves quality of l…

This study looked at whether taking phytosterols (natural plant compounds) for 3 months could improve liver health, cholesterol, and insulin levels in 27 adults with nonalcoholic fatty liver disease (NAFLD). Participants took daily supplements while researchers tracked changes in…

This study tested a new medication called Mazdutide to help adults with obesity or overweight lose weight. About 179 participants took the drug or a placebo for 32 weeks to see how much weight they lost. The goal was to find a safe and effective way to manage weight, but ongoing …

This study tested how orforglipron, an experimental pill, changes body fat compared to a placebo in 120 adults with obesity or overweight (but without diabetes). Participants were followed for about 8 months. The main goal was to see if the drug reduces visceral fat—the deep bell…

This study tested whether adding a new medicine (NNC0165-1875) to the existing weight-loss drug semaglutide helps people with obesity lose more weight. 120 adults with a BMI between 30 and 45 took part. Participants received either the new drug plus semaglutide or a placebo plus …

This study looked at the safety and effectiveness of the weight-loss medicine Saxenda in 300 obese adults and teenagers in Taiwan. Participants took the medicine as part of their regular care for about 26 weeks. The main goal was to track any side effects, and the results help co…

This study tested a once-daily pill called orforglipron to see if it helps people with obesity or overweight maintain weight loss they achieved in a previous study. 376 adults who completed the earlier weight-loss program took either the pill or a placebo. The goal was to measure…

This early-stage study tested a new drug called AMG 133 in 120 adults with overweight or obesity. Researchers gave multiple doses under the skin to see how the drug behaves in the body and whether it is safe. The goal was to gather information for future studies, not to treat or …

This study tested a new magnetic system (MagDI) in 10 adults with obesity and type 2 diabetes. The device creates a new connection in the small bowel to help with weight loss and blood sugar control. The main goals were to see if the procedure is safe and works as intended, witho…

This study compared time-restricted eating (eating only during a 6-8 hour window each day) to daily calorie restriction for weight loss and blood sugar control in 32 adults with type 1 diabetes and obesity. Participants followed their assigned diet while continuing insulin and gl…

This study tested two lifestyle programs for overweight or obese pregnant women to help them manage weight gain during pregnancy. 123 women participated, receiving either weekly group sessions on diet and activity or enhanced standard care. The goal was to see if these programs c…

This study tested whether a probiotic called Bifidobacterium breve, taken alongside exercise, helps healthy but overweight adults lose more body fat. About 95 people with a BMI between 25 and 30 took either the probiotic or a placebo for 12 weeks. Researchers measured changes in …

This study tested a virtual health program for African immigrants aged 25-75 who are uninsured and have at least two risk factors like high blood pressure, prediabetes, or obesity. Participants used Bluetooth scales and blood pressure monitors to track their health over six month…

This study tested whether a capsule containing heat-killed Akkermansia bacteria can help overweight or obese adults lose weight and improve their metabolism. 61 participants took either the probiotic or a placebo for a period of time. Researchers measured changes in body weight, …

This study tested a new medicine called PF-07976016 in 263 adults with obesity to see if it is safe and helps with weight loss. Participants received either the study drug or a placebo (fake pill) for a period of time. The main goal was to measure changes in body weight and any s…

This study looked at whether receiving daily text messages on your phone can help with weight loss. 120 adults with obesity were split into two groups: one got standard weight-loss classes, and the other got those classes plus daily texts. The goal was to see if the text group lo…

This study tested a once-weekly injection of semaglutide (2.4 mg) in 150 Asian adults with obesity (BMI 25 or higher). Participants received either the drug or a placebo, plus lifestyle advice, for about a year. The main goal was to see how much weight they lost. Results showed t…

This study tested whether a new investigational medicine called CagriSema (a combination of two drugs) can reduce kidney damage in people with chronic kidney disease, type 2 diabetes, and overweight or obesity. About 626 participants received either CagriSema, one of its componen…

This study tested whether a new drug called VTX3232, taken alone or with semaglutide, is safe for people with obesity. About 176 adults with a BMI between 30 and 42 took part. The study lasted 12 weeks and checked for side effects and changes in inflammation levels.

This study tested whether colchicine, a common anti-inflammatory medicine, could improve metabolism in people with obesity who have high inflammation and high insulin levels but not yet high blood sugar. About 152 adults and teens took colchicine or a placebo daily for 12 weeks. …

This study tested a once-daily oral medication called orforglipron against a placebo in over 1,600 adults who are overweight or have obesity and also have type 2 diabetes. The goal was to see if the drug helps with weight loss and improves blood sugar control. Participants took t…

This study tested a weekly injection of semaglutide (2.4 mg) to help adults with excess body weight lose weight. 242 participants received either the drug or a placebo for about one year. The main goal was to see how much weight they lost and if at least 5% of body weight was red…

This study looked at whether the medication lisdexamfetamine (LDX) can help adults with binge-eating disorder and obesity avoid relapsing after initial treatment. 61 participants who responded to acute treatment were randomly assigned to continue LDX or switch to a placebo. The g…

This study tested a new medicine called NNC0519-0130 in 354 adults with overweight or obesity. Participants received 1-2 injections once a week for about 42 weeks. The main goal was to see how much weight they lost as a percentage of their body weight. The study also looked at ho…

This study tested a high dose (7.2 mg) of semaglutide, a once-weekly injection, in 1407 adults with obesity. Participants also received lifestyle advice. The goal was to see how much weight they lost compared to those on a lower dose or placebo. Results showed significant weight …

This study looked at whether pea protein can help people with obesity keep their muscle mass while losing weight. About 60 adults aged 30 to 50 took part. Researchers compared the effects of pea protein and whey protein on muscle size and strength.

This study tested a new blood test called LLIFT to see if it can accurately diagnose fatty liver and NASH without needing a liver biopsy. Researchers studied 158 people at high risk due to obesity, diabetes, or high blood pressure. The goal is to find a simple, non-invasive way t…

This study tested whether a mindfulness-based training program could help adults who had lost weight avoid regaining it. Researchers enrolled 48 people who had lost weight through bariatric surgery, medical programs, or lifestyle changes. Participants practiced mindfulness techni…

This study tested a program called HEALTH to help overweight adults prevent weight gain and lose weight. It was delivered through the Parents as Teachers home visiting program. 620 parents took part. The goal was to see if the program works in real-world settings.

This study tested a program where community health workers visited families at home to help manage childhood obesity. 300 children aged 2-6 with overweight or obesity took part. The program aimed to improve diet, activity, and fitness to lower the child's BMI. Results will guide …

This study tested whether a fully-automated digital diabetes prevention program works as well as standard human coach-based programs. 368 adults with prediabetes and overweight took part. The goal was to see if the digital program could help people lose weight, increase physical …

This study tested health programs to prevent obesity in 500 healthy children aged 6-12 living in Gharbia, Egypt. Researchers measured changes in weight, height, BMI, and blood tests like cholesterol and hemoglobin. The goal was to see if these interventions could help children ma…

This study tested a year-long online program to help adults aged 40-70 who are at risk for heart disease become more active. Participants received a fitness tracker, online coaching, and educational sessions. The goal was to see if this approach could increase daily steps and hel…

This study tested whether a health education program that focuses on reducing sugary drinks and juices, plus home delivery of bottled water, can lower obesity risk in Hispanic mothers and their infants. Over 200 mother-infant pairs were randomly assigned to one of three groups fo…

This study tested whether starting a lifestyle program before pregnancy can improve health for both mother and baby. Researchers enrolled 99 women who had a previous full-term pregnancy and were planning another within two years. The program focused on diet and exercise to reduce…

This study tested a short pre-session program to help people at risk for type 2 diabetes attend more classes and lose more weight. It involved 483 adults from underserved backgrounds, including Hispanic and Black communities. The goal was to make the National Diabetes Prevention …

This study tested whether an educational program for pregnant women who are overweight or obese could reduce the chance of their babies gaining weight too quickly in the first two years of life. The program focused on healthy eating and lifestyle habits during pregnancy. The goal…

This study tested whether taking a daily supplement of lactoferrin, a protein found in cow's milk, could help prevent iron deficiency anemia in pregnant women with obesity. 23 women at risk for anemia took part. The main goal was to see if the approach was practical and acceptabl…

This study tested a program to help pregnant women who are overweight or obese avoid gaining too much weight. It included 416 African American and Hispanic women in Philadelphia who were part of the WIC program. The program used text messages and guidance to support healthy eatin…

This study looked at whether functional inspiratory muscle training (special breathing exercises) can improve body composition, heart health, and breathing in people with obesity. 45 adults aged 25-60 with a BMI between 30-40 took part. The goal was to see if these exercises coul…

This study looked at whether delivering healthy meals to low-income women with obesity after childbirth is practical and helpful for weight management. Eleven women who had recently given birth received weekly meal deliveries and reported how much they ate. The goal was to see if…

This early-stage study tested a new drug called eloralintide, given alone or together with tirzepatide, in 188 adults who are overweight or have obesity. The main goals were to check safety, side effects, and how the drugs move through the body. Participants received weekly injec…

This study looked at whether an 8-week Pilates exercise program could improve breathing in overweight and obese women. 54 women took part, doing core and abdominal exercises three times a week. Researchers measured lung function, breath-holding time, and quality of life before an…

This study tested two methods to strengthen the staple line during weight-loss sleeve surgery: using a medical glue (cyanoacrylate) or a piece of the patient's own abdominal tissue (omentum). 70 adults aged 18-65 with obesity were randomly assigned to one of the two groups. The g…

This study tested whether a short cognitive behavioral therapy (CBT) program before weight-loss surgery helps patients stick to healthier eating habits afterward. About 94 adults preparing for bariatric surgery took part. The goal was to see if the therapy improves dietary restra…

This study tested a GLP-1 drug (a type of diabetes medication) in 96 people with obesity but without diabetes. The goal was to see if it reduces cravings, hunger, stress, and weight. Participants received either the drug or a placebo, and researchers measured changes using questi…

This study tested a wearable ear device that sends gentle electrical pulses to a nerve to help control appetite. Sixty healthy adult women each had two visits: one with the device on and one with it off. Researchers measured how much they ate, their hunger levels, and food cravin…

This study tested a self-help tool called EMBER to see if it helps veterans with obesity take part in VA weight management programs. About 470 veterans were randomly assigned to receive EMBER or just a list of programs. Researchers checked how many used the programs after 2 and 6…

This early-stage study tested a new drug called AMG 786 in 65 healthy adults and people with obesity. The main goal was to check if the drug is safe and how the body processes it. Researchers gave single or multiple doses and monitored for side effects. This is a first step to se…

This study looked at whether antioxidants in orange juice can help the body respond better to insulin. Overweight but otherwise healthy women drank either orange juice or a similar-tasting drink every day for three months. Researchers measured insulin sensitivity, cholesterol, an…

This study tested whether a daily psychobiotic supplement (containing specific probiotic strains) could improve mental health, quality of life, and weight loss in obese women following a weight-loss diet. 28 women took either the supplement or a placebo for 4 weeks. Researchers m…

This study tested whether adding mindfulness and acceptance skills to standard weight loss counseling helps people lose more weight. 276 adults with overweight or obesity participated. Researchers compared different combinations of awareness, acceptance, and values-clarity exerci…

This study tested a weekly injection of semaglutide (2.4 mg) in 529 adults with obesity and a type of heart failure where the heart pumps normally but doesn't fill properly. The goal was to see if the drug improves daily symptoms, physical function, and body weight compared to a …

This study looked at 90 veterans with obesity who took GLP-1 medicines (semaglutide or tirzepatide) for six months. Researchers found that participants reported significant improvements in depression symptoms, eating disorder behaviors, and quality of life—including less pain and…

This study tested a dietary supplement called WM Formula in 20 adults with high body fat. The goal was to see if it could increase GLP-1, a hormone that helps control appetite and blood sugar. Participants took the supplement or a placebo and had blood tests over several hours. T…

This study tested two types of balance exercises—whole-body vibration therapy and balance board training—in 44 obese adults with mild knee osteoarthritis. Over eight weeks, researchers measured pain, mobility, and quality of life to see which method worked better. The goal was to…

This study tested whether MitoQ, a dietary supplement, can improve airway function in 47 obese adults with poorly controlled asthma. Participants took MitoQ or a placebo for 14 weeks. The main goal was to see if MitoQ reduces airway reactivity, a key asthma symptom.

This study tested a new injectable medicine, NNC0662-0419, in 100 adults with overweight or obesity. The main goal was to check its safety and how the body processes it, as this was the first time it was given to humans. Participants received either the study drug or a placebo ov…

This study tested whether tradipitant can reduce nausea and vomiting caused by GLP-1 receptor agonist drugs (like Ozempic or Wegovy) in 124 healthy overweight or obese volunteers. Participants received either tradipitant or a placebo, and tracked their symptoms daily. The goal wa…

This study tested whether using ultrasound to find the right spot for spinal anesthesia works better than the usual method of feeling for landmarks in obese women having C-sections. 100 obese pregnant women were randomly assigned to either ultrasound guidance or the standard land…

This study looked at the safety of giving lidocaine (a numbing medicine) during weight-loss surgery. Fifty adults having laparoscopic bariatric surgery received lidocaine, and researchers measured its levels in the blood at several points and watched for side effects like seizure…

This study tested whether a phone-based cognitive behavioral therapy program could help people with severe obesity overcome food addiction. 154 adults with a BMI of 35 or higher and a food addiction diagnosis took part. The therapy group received 12 phone sessions over 18 weeks, …

This study tested a combination medicine called CagriSema (cagrilintide and semaglutide) in 164 adults with overweight or obesity. Researchers measured changes in appetite, food intake, and brain activity using scans and questionnaires. The goal was to understand how the medicine…

This study tested if using warm saline (body temperature) to rinse the staple line during laparoscopic sleeve gastrectomy reduces early bleeding after surgery. 200 adults having weight-loss surgery were randomly assigned to receive either warm or room-temperature irrigation. The …

This study tested a new video-assisted breathing tube device (SaCoVLM™) in 57 obese patients undergoing weight-loss surgery. The goal was to see if it helps doctors place a breathing tube more easily and safely. The device combines a regular airway mask with a camera to guide ins…

This study looked at whether a stretching routine could reduce heart health risks in pregnant women with obesity. 224 women from 27 to 37 weeks of pregnancy either did stretching exercises or followed standard moderate activity guidelines. The main goal was to see if stretching i…

This study tested whether a weight loss program before total knee replacement helps people with obesity have better outcomes. 24 adults aged 50-75 with a BMI between 35 and 40 were randomly assigned to either a 3-month very low-calorie diet and exercise program before surgery, fo…

This study looked at whether quercetin, a compound found in foods like apples and onions, changes how the body absorbs sugar. Researchers gave 24 obese adults, some with type 2 diabetes, either quercetin or a placebo during a sugar-drink test. They measured blood sugar levels to …

This early-stage study tested a new medicine (NNC0487-0111) for weight control in 36 Chinese adults with overweight or obesity. The main goal was to check safety and how the drug moves through the body. Participants received either the study drug or a placebo by injection, and we…

This study tested whether a weekly injection of semaglutide (2.4 mg) helps people with obesity and knee osteoarthritis lose weight and reduce knee pain. About 400 adults with a BMI of 30 or higher and moderate knee arthritis were randomly assigned to receive semaglutide or a plac…

This study tested whether a 12-week remote exercise program using a mobile app is practical and helpful for 20 adults with obesity and poorly controlled asthma. Participants received a personalized exercise plan and were monitored remotely. The main goal was to see if people woul…

This study tested a new drug, NNC0487-0111, given as injections under the skin, to see if it is safe and how it works in the body. It involved 125 adults aged 18-55 who were overweight or obese. The main goal was to check for side effects and measure how the drug behaves in the b…

This study tested a new medicine called NNC0519-0130 for people with overweight or obesity. Researchers wanted to see if different ways of slowly increasing the dose could reduce side effects. About 134 adults with a BMI between 27 and 45 took part. The study lasted 24 weeks and …

This study tested a once-weekly injection called retatrutide in 445 people who are overweight or have obesity and also have knee osteoarthritis. The goal was to see if the drug helps with weight loss and reduces knee pain. Participants received either the drug or a placebo for ab…

This study tested a new drug (LY3841136) alone and with another weight-loss drug (tirzepatide) in 128 Japanese adults with obesity or overweight. The main goal was to check safety and side effects, and to see how the body processes the drugs. The study is complete, and results wi…

This study looked at whether a special breathing maneuver during weight-loss surgery helps patients recover better. 230 obese adults having bariatric surgery were randomly assigned to receive the maneuver or not. The goal was to see if it reduced shortness of breath and the need …

This study looked at 105 adults who have both obesity and trouble affording enough food. Participants received standard weight-loss counseling plus either food vouchers or home-delivered healthy groceries for 24 weeks. The goal was to see if adding food support helps them lose mo…

This study looked at whether intermittent fasting (not eating for certain periods) can improve how well the pancreas makes insulin in people with early type 2 diabetes. 51 adults with diabetes and obesity took part. The goal was to see if fasting could help control blood sugar an…

This study checked whether the experimental drug survodutide (BI 456906) causes any heart rhythm changes in 110 adults with overweight or obesity. Participants received weekly injections of survodutide or a placebo for about 30 weeks, along with a single dose of moxifloxacin (a d…

This study looked at whether taking a daily high dose of vitamin D3 (10,000 IU) for 12 weeks could improve muscle strength and muscle mass in older adults (60+) with obesity. 29 participants from southern Mexico completed the trial. Researchers measured handgrip strength, muscle …

This study looked at whether CagriSema, a combination of two medicines, can lower how much people eat and their appetite. 62 adults with overweight or obesity received either CagriSema or a placebo for about 32 weeks. Researchers measured food intake and stomach emptying to see i…

This study looked at whether gentle spinal traction (a pulling force on the spine) can reduce pain and improve movement in people with obesity and long-term low back pain. Forty-nine adults aged 35-60 took part, some with obesity and some with normal weight. They received 30 minu…

This study tested a psychological program called well-being therapy in 50 adults with obesity. The goal was to see if improving mental health could help them adopt sustainable, healthy eating habits and lose weight. Participants attended therapy sessions and were followed by medi…

This study tested a program that combines cognitive behavioral therapy and motivational interviewing to help people with obesity reduce emotional eating and increase psychological resilience. 81 obese adults participated, with half receiving the program and half not. Results show…

This study tested a 4-hour workshop based on acceptance and commitment therapy (ACT) to help women with obesity adopt and maintain healthy lifestyle behaviors. Fifty-two women participated, completing questionnaires and physical measurements before, one week after, and one month …

This early-stage study tested a new medicine called BI 3006337 in 64 adults who are overweight or have obesity and also have fatty liver disease. The main goal was to see if different doses of the weekly injection are safe and tolerable. Participants received either the drug or a…

This study tested a smartphone app to help young adult cancer survivors (ages 18-39) lose weight and be more active. The app tracked diet, weight, and exercise as part of a behavioral program. The goal was to see if this approach is practical and liked by participants. It focused…

This study tested whether people having laparoscopic gastric bypass surgery can safely go home the same day instead of staying overnight. 200 adults with obesity were randomly assigned to same-day or one-day discharge. The main focus was on safety, readmission rates, and whether …

This study tested whether a special probiotic mixture can relieve belly pain and discomfort in obese adults with irritable bowel syndrome (IBS). Eighty participants took the probiotic or a placebo for 10 weeks, and researchers tracked their symptoms and gut bacteria. The goal was…

This study tested whether a common weight-loss surgery, laparoscopic sleeve gastrectomy, could be safely performed as a day-case procedure—meaning patients go home the same day. Thirty adults with obesity were enrolled, and researchers tracked how many needed unexpected overnight…

This study tested a behavioral weight loss program for college students ages 18-25 with a BMI of 25 or higher. The program used a 'small change' approach to help students lose weight. 42 students participated, and the study measured how acceptable the program was and how much wei…

This early-stage study tested a new medicine called NNC0519-0130 in 20 Chinese men who were overweight or had obesity. The goal was to see how the drug moves through the body and if it is safe. Participants received either the drug or a placebo for about 28 weeks, with up to 7 di…

This study looked at how resistance exercise (like weight lifting) improves insulin sensitivity and muscle health in people with insulin resistance and obesity. Researchers studied 58 adults aged 50-75 to understand changes in muscle strength, insulin response, and body compositi…

This study looked at how different exercise intensities change levels of ghrelin, a hormone that controls hunger, in 40 adults with obesity and prediabetes. Researchers measured ghrelin in the blood and checked appetite, insulin sensitivity, and blood vessel function. The goal wa…

This study examines whether the body's ability to switch between burning sugar and fat (metabolic flexibility) predicts changes in metabolic health over 16 years. Researchers will re-evaluate 18 adults who took part in a study in 2008-2009, measuring weight, blood sugar, choleste…

This study looked at how an experimental drug for obesity (HRS-7535) interacts with four common medicines: acetaminophen (pain relief), digoxin (heart medication), rosuvastatin (cholesterol), and omeprazole (acid reflux). It involved 40 overweight or obese adults aged 18-50. The …

This study looked at how regular exercise changes appetite and metabolism in overweight teens who are not active. Researchers measured hunger levels and blood markers after a meal in 31 teens assigned to either an exercise program or a control group. The goal was to understand th…

This study looked at 90 people who had sleeve gastrectomy surgery for obesity but didn't lose enough weight. Researchers measured their stomach size two years later to see if a larger leftover stomach was the reason. The goal was to find a way to decide on the best next treatment…

This small pilot study tested whether offering financial rewards for exercise and healthy food could help people with obesity or diabetes. Eight participants from a low-income community were split into two groups to see if incentives increased walking and improved weight. The mai…

This study looked at how food moves through the stomach and gut in 20 men—some with obesity and some at a healthy weight. Researchers used MRI scans and blood tests to measure stomach emptying, gut blood flow, and hunger-related hormones. The goal was to learn more about what cau…

This study looked at 20 obese teenagers (ages 13-20) who were scheduled for bariatric surgery. Researchers measured liver fat and how the body processes energy before and one year after surgery. The goal was to understand how the surgery affects liver health and metabolism, not t…

This study measured brain fluid chemicals in 51 adults with obesity before and after bariatric surgery or diet-induced weight loss. The goal was to understand why surgery leads to better long-term weight loss by looking at appetite-regulating brain signals. Results may help devel…

This study looked at how blood sugar levels, gut bacteria, and iron buildup in the brain are connected to thinking skills in people with obesity. Researchers followed 128 adults aged 30-65, some of whom lost weight through surgery or diet. They used glucose monitors, brain scans,…

This study follows up with people who were in the SELECT obesity medication trial to see how their health changes over the long term. No new treatment is given—participants just fill out health questionnaires every 6 months for up to 10 years. The goal is to track serious health …

This study looked at health data from over 550,000 Chinese adults to see how being overweight or obese affects heart disease. Researchers used national survey information to find out how common heart problems are in this group and how they change over time. No treatments were giv…

This study looked at whether sleeping longer can improve how the body processes sugar in people with obesity. 31 adults who slept less than 7 hours a night were split into two groups: one tried to sleep more, the other kept their usual habits. Researchers measured changes in insu…

This study looked at whether stopping certain diabetes medications (incretin-based therapies) before an upper endoscopy reduces the amount of food or liquid left in the stomach. Having too much stomach content can make the procedure harder or riskier. The study included 69 adults…

This study looked at how the body's metabolism changes when people overeat or fast, and how different diets (like high-protein or high-fat) affect those changes. About 200 healthy adults aged 18-55 took part. They stayed in a special room that measured their calorie burn, and res…

This study looked at how different amounts of insulin affect blood sugar in people with overweight, prediabetes, and fatty liver disease. Researchers used a special clamp technique to carefully control insulin levels and measure changes. The goal was to better understand the role…

This study tested a 4-month nutrition education program for 811 ethnic minority children aged 5-16 in Tra Vinh, Vietnam. The program included monthly lessons, videos, and support activities. Researchers measured changes in weight, height, diet, and physical activity to see if the…

This study looked at why some people become obese by examining eating behaviors and food preferences, especially for high-fat foods. Researchers studied 669 healthy adults, including Pima Indians and Caucasians, to understand risk factors for obesity. Participants filled out ques…

This study looked at 97 adults with obesity to see if following the EAT-Lancet (Planetary Health) diet is linked to their natural sleep-wake patterns (chronotype) and psychological well-being. Researchers measured body size, blood markers, diet habits, and used questionnaires to …

This study looked at how type 2 diabetes works in children and young adults aged 12 to 25. Some participants took diabetes medicine with or without extra insulin to see if resting the pancreas could help it make more insulin. The study also compared them to healthy volunteers to …

This study looked at why overweight or obese pregnant women choose to take part in a 12-week program that includes nutrition advice and weekly exercise sessions. Researchers tracked 195 women to see which factors—like age, health history, or motivation—influenced their participat…

This study looked at 44 adults with obesity to see if symptoms like shortness of breath and rapid breathing are linked to how well they can move and exercise. Participants completed breathing questionnaires, walking tests, and strength tests. The goal was to better understand the…

This study looked at how physical activity relates to quality of life and mental health in 38 adults with severe obesity (BMI over 40). Participants wore activity monitors for 6 weeks to track sitting, standing, and movement. The goal was to understand these connections, not to t…

This study looked at how common weight-related health problems are in people of different weights in India, Pakistan, Philippines, and Vietnam. Over 1,100 adults with at least one weight-related complication took part. No treatment was given; participants continued their usual ca…

This study looked at three different breathing techniques to increase oxygen levels in obese patients before surgery. The goal was to find the fastest and safest method, checking if any caused stomach swelling that could lead to complications. 75 adults took part, and the results…

This study tested whether using a special breath test (indirect calorimetry) to measure energy needs can help doctors provide the right amount of nutrition to critically ill patients with obesity who are on breathing machines. The study involved 60 adults from intensive care unit…

This study tracked nearly 4,800 adults in France who were already in a weight-loss program to see how COVID-19 confinement changed their weight, sleep, and habits. Researchers looked at factors like stress, anxiety, physical activity, and screen time. The goal was to understand h…

This study looked at how a new weight-loss drug called BI 456906 affects the way the body processes three common drugs: bupropion, caffeine, and midazolam. Thirty-four healthy adults with overweight or obesity took these drugs alone and then again while receiving weekly injection…

This study looked at whether eating the same amount of food at different times of day affects weight, body fat, and metabolism in people with obesity. 38 adults were given all their meals and snacks and told to eat either during the day or later in the evening. The goal was to un…

This study looked at 155 adults who had weight-loss surgery to see if using a low-flow or standard-flow anesthesia gas changed inflammation levels after surgery. Researchers measured blood markers of inflammation before and after the operation. The goal was to learn more about ho…

This study followed 46 obese men who had weight-loss surgery (gastric banding, bypass, or sleeve gastrectomy) to see how it changed their sperm quality and other factors related to fertility. Researchers compared sperm count and other characteristics before and after surgery. The…

This study looked at 80 obese adults having spinal surgery to see if adjusting the ventilator based on each person's lung stiffness works better than using a standard setting. The goal was to improve oxygen levels during surgery and reduce lung problems afterward. Researchers mea…

This study examined 549 older adults to see if there is a connection between metabolic syndrome and vitamin D levels. Researchers collected health information and blood samples from participants aged 65 and older. The goal was to understand how these factors relate, not to test a…

This study looked at how stress from the COVID-19 pandemic and changes in the food environment influenced eating behaviors and weight in adults. Over 5,000 English-speaking adults aged 18 and older completed online surveys about their mental health, eating habits, and weight chan…

This study looked at how many calories people burn through physical activity and whether that affects body weight and diabetes risk. Researchers followed 2,506 Black adults from Ghana, South Africa, Seychelles, Jamaica, and the United States for two years. They used special water…

This study checks in on mothers and their children 12 years after a pregnancy lifestyle program. The goal is to see if healthy eating and activity during pregnancy affected the child's body composition and the mother's health long-term. About 497 families from the original TOP st…

This study looked at how certain immune cells (eosinophils) interact with fat tissue in people with obesity and insulin resistance. Four participants had fat biopsies and blood tests to measure immune cell levels and inflammation. The goal was to better understand these interacti…

This study tested three low-cost methods to help adults in Yomitan Village, Okinawa, reduce stress and adopt healthier habits. Forty-five adults with overweight or early metabolic syndrome were randomly assigned to receive health leaflets, wear functional clothing, or follow a si…

This study looked at whether three weeks of alternate-day fasting (eating normally one day, fasting the next) changes how the heart and brain use energy compared to a typical Western diet. Sixteen overweight adults aged 55-70 with insulin resistance took part. Researchers used ad…

This study tested whether adding carob to a Western-style breakfast can help regulate hunger, insulin, and blood sugar. Twenty healthy, normal-weight men participated. Researchers measured appetite hormones and self-reported fullness after the meal. The goal was to understand car…

This study measured levels of a recently discovered hormone called 26RFa in 62 women. Researchers compared obese women with or without type 2 diabetes to healthy-weight volunteers. They also checked how the hormone changed after weight-loss surgery (sleeve gastrectomy). The goal …

This study looked at whether eating protein at different times of day affects how the body uses energy and whether it changes cravings for snacks. Researchers compared two patterns of daily protein intake in 53 adults with obesity. The goal was to see if a high-protein breakfast …

This study looked at 110 adults with type 2 diabetes to compare two easy methods of measuring hidden belly fat: a simple waist measurement and a device that uses a mild electrical current (bioelectric impedance). The goal was to see which method better predicts heart disease risk…

This study followed 1,500 obese patients to see what factors help diabetes go away and other health issues improve after weight-loss surgery. Researchers compared patients who had surgery with those who did not, tracking weight, blood sugar, and quality of life. The goal is to be…

This study looked at how lean and obese people differ in their sense of thirst and how their bodies handle water. Researchers had 75 healthy men stay in the hospital for 13 days and undergo tests like going without water for 24 hours. The goal was to understand if body fat change…

This study used a special 3D camera system (stereophotogrammetry) to take pictures of people's torsos without any radiation. Researchers aimed to better understand body shapes in people with scoliosis, chest wall deformities, obesity, and healthy volunteers. About 199 participant…

This study looked at how community organizations can successfully run a healthy lifestyle program called Deaf Weight Wise for Deaf adults who use American Sign Language. Researchers worked with partners in Buffalo, Rochester, and Syracuse, New York, to see if they could deliver t…

This study tested simple paper and electronic tools to measure the types of foods available in people's homes, focusing on items that affect health. About 439 English- or Spanish-speaking adults who do most of their household's grocery shopping took part. The goal was to create r…

This study looked at how losing weight through diet changes affects iron levels in people with obesity and iron deficiency. Researchers measured a protein called hepcidin, which controls iron in the body, along with iron levels before and after a 60-day diet plan. The goal was to…

This study looked at how a single session of walking or jogging changes appetite-related hormones and brain activity in 40 adults who were either normal weight or overweight/obese. Researchers measured hormones like oxyntomodulin and ghrelin in blood samples and asked about hunge…

This study looked at how daily rhythms affect fat cell genes and insulin response in 28 obese women scheduled for bariatric surgery. Researchers measured changes in insulin sensitivity before and 12 weeks after surgery. The goal was to understand how fat cells work, not to test a…

This study looked at how vitamin E is absorbed and used by women who are normal weight, overweight, or have type 2 diabetes. Researchers measured vitamin E levels in blood and tissues after giving different doses and meals. The goal was to learn more about vitamin E needs in wome…

This study looked at how one session of exercise changes the brain's response to insulin in adults aged 40 to 80 who are overweight or obese. Researchers used MRI scans to measure brain activity and tested memory and thinking skills. The goal was to learn more about how exercise …

This study tested whether sending specific text messages at the right time helps young adults with overweight or obesity meet their daily goals for weighing themselves, being active, and limiting certain foods. Over 200 participants used a mobile weight loss program and received …

This study followed about 1,900 pregnant women (some with HIV, some without) and their children for two years to see how HIV and the drug dolutegravir affect weight gain and body fat. Researchers measured things like weight, metabolism, and blood markers in both mothers and babie…

This study looked at whether community-based programs can help people in Appalachian Kentucky eat more fruits and vegetables and feel more secure about having enough food. 281 adults from Laurel and Pike counties took part. Researchers measured diet quality, food security, and sk…

This study looked at whether training the muscles used for breathing can improve heart health and mood in women who have gone through menopause. Researchers tested 28 women aged 50 to 75 by having them do breathing exercises and measuring how their bodies responded during walking…

This study looked at 37 obese adults to understand why their brains show less pleasure when tasting food. Researchers think insulin resistance might be the cause. They used brain scans to measure responses and checked if weight loss could improve brain signaling. The goal is to l…

This study looked at whether the smallest meaningful change in bone density scans is different for people with obesity compared to those without. Researchers measured bone density twice in 120 adults with a BMI over 30. The goal was to improve accuracy when interpreting bone scan…

This study tested whether adding a nutrition program (BfedBwell) to an existing exercise program (BfitBwell) is practical and well-liked by cancer survivors who are overweight or obese. Twenty adults who finished cancer treatment within the last five years took part. The main goa…

This study looked at how diet influences inflammation in 393 healthy and obese adults. Researchers measured immune cells and blood markers after a high-fat meal to understand the link between diet, metabolism, and inflammation. The goal was to learn more about how eating habits a…

This study looked at 64 obese adults to see if having obesity hypoventilation syndrome (OHS) adds extra problems beyond obesity alone. Researchers measured how far people could walk in 6 minutes, their muscle strength, and their quality of life. The goal was to understand if OHS …

This study looked at how the body burns calories when exposed to different temperatures, from about 61°F to 88°F. Researchers wanted to learn if brown fat—a type of fat that burns energy to keep you warm—becomes active in adults when it's cold. Healthy men and women stayed in a h…

This study looked at 216 women ages 18-45 to see if body weight affects genital hygiene, toilet behaviors, body awareness, and bladder symptoms. Researchers compared normal-weight women to those who are overweight or obese. The goal is to raise awareness and improve quality of li…

This study tested a home-based lifestyle program for people with severe sleep apnea and obesity. 17 adults used remote monitoring devices and received health coaching to improve their health and quality of life. The main goal was to see if the system was easy to use and helpful, …

This study looked at levels of a hormone called prolactin in the gum fluid of 26 obese people with and without gum disease (periodontitis). Researchers measured prolactin before and after non-surgical gum treatment to see if it changed. The goal was to better understand the link …

This study looked at whether inflammation in belly fat can cause confusion or memory problems after surgery. Researchers followed 115 patients having hip or heart surgery. They measured thinking skills and checked fat tissue for signs of inflammation. The goal was to understand i…

This study looked at how different types of diets affect the number of calories people burn and their risk for diseases like diabetes and heart problems. 234 adults who were overweight or obese took part. Researchers measured their total energy use and resting metabolism to under…

This study followed 255 people with severe obesity who had weight loss surgery. Researchers wanted to see if losing weight improved liver scarring (fibrosis) using simple blood tests instead of a liver biopsy. The main goal was to check how well two blood tests (Fibrotest and tra…

This study tested whether showing Nutri-Score labels (A to E) on a food delivery app helps people choose healthier meals. Over 800 adults who order food online at least once a month made hypothetical choices in a simulated app. Some saw labels, some saw labels plus extra educatio…

This small pilot study tested whether people with major depression who eat a lot of ultra-processed foods could reduce them. 20 participants tried a personalized diet change. The goal was to see if this approach is feasible and acceptable, not to measure mood effects directly.

This study followed 200 children and young adults who are overweight or have high blood pressure. Researchers collected health information from their medical records to learn how weight affects the heart over time. The goal is to better understand these risks, not to test a new t…

This completed study followed 300 obese adults (BMI over 30) who were prescribed positive airway pressure (CPAP) therapy for sleep-disordered breathing. Researchers measured how many patients used their CPAP machine for at least 4 hours per night on 70% of nights within the first…

This study looked at whether eating less salt before bed can improve blood pressure and body rhythms in people with obesity. Researchers measured blood pressure, body temperature, and sleep-related hormone changes in 53 adults. The goal was to learn how salt timing affects health…

This study looked at how the body processes food and loses weight after bariatric surgery. Researchers used advanced tools to measure changes in proteins and other molecules in 7 participants. The goal was to find clues that could explain why some people lose more weight than oth…

This study looked at 116 overweight or moderately obese adults who had a procedure called endoscopic sleeve gastroplasty, which uses stitches to reduce stomach size. The goal was to find factors—like blood markers—that predict who will lose at least 10% of their weight a year lat…

This study looked at 1290 adults with obesity (BMI 30 or higher) who had weight-loss surgery and needed a breathing tube. The goal was to find out how often doctors face a difficult airway—when placing the tube is harder than usual. By tracking patient details and any complicatio…

This study looked at 146 healthy women of African, African-American, and white backgrounds to see if race affects how we screen for diabetes and heart disease. Participants had blood tests, body fat measurements, and meal tests over four visits. The goal was to find the best scre…

This study looked at how an 8-week personalized exercise program affects heart and blood vessel function in 59 men with obesity or type 2 diabetes. Participants were compared to healthy volunteers, both trained and untrained. The goal was to see if exercise can improve cardiovasc…

This study looked at brain activity in 187 young adults while they anticipated and tasted milkshakes. Using MRI scans, researchers measured responses in brain areas linked to reward. The goal was to understand how these brain patterns might relate to obesity risk.

This study looked at how stress, behavior, and social factors affect weight loss and heart health in people from disadvantaged backgrounds. Researchers tracked 15 adults with overweight or obesity to understand what helps or hinders weight management. The goal was to gather infor…

This study looked at how trans fats from natural sources (like dairy) and industrial sources (like processed foods) affect insulin resistance in 66 obese women. The goal was to see if these different types of trans fats have different effects on the body's ability to use insulin.…

This study looked at how losing weight changes body fat and metabolic health in adults with excess weight. 74 men and women followed a 12-week low-calorie diet. Researchers measured blood fats and insulin resistance to see if greater fat loss leads to better health improvements.

This study tested how CagriSema, a drug for weight management, changes the way the body processes two common medications: atorvastatin (for cholesterol) and warfarin (a blood thinner). Thirty-four adults with overweight or obesity took these medications before and after starting …

This study looked at how common sleep apnea is in obese pregnant women and whether using a CPAP machine can improve health for both mother and baby. Researchers followed 89 women with a BMI over 35 who were past 24 weeks of pregnancy. The goal was to see if treating sleep apnea r…

This study examined how obesity impacts hospital stays and recovery in trauma patients aged 60 and older. Researchers compared obese and non-obese patients to see if weight affected length of stay, complications, or treatment costs. The goal was to clarify conflicting evidence an…

This early-stage study tested a single oral dose of the experimental drug monlunabant in 73 healthy men of normal weight, half Japanese and half Caucasian. The main goal was to check safety and how the drug moves through the body. Participants were randomly assigned to receive mo…

This study aimed to understand why some people develop type 2 diabetes by looking at genetic and lifestyle factors. About 1,759 overweight adults aged 18-55 took part in tests measuring how their bodies handle sugar and store energy. The goal was to find genetic markers and early…

This study looked at whether a 12-week time-restricted feeding plan (eating only during a set window each day) is practical and acceptable for older adults (ages 65-80) who have mild cognitive impairment and obesity. The goal was to see if people would stick with the diet and to …

This study looked at 49 obese adults with asthma to understand why they often have more severe symptoms and don't respond well to standard treatments. Researchers used special MRI scans and genetic analysis of lung cells to examine airway damage and scarring. The goal was to unco…

This study looked at how the hormone glucagon affects the liver's ability to break down proteins and fats. Researchers studied 21 people with obesity, type 2 diabetes, and fatty liver disease to understand if the body becomes resistant to glucagon. The goal was to learn more abou…

This completed study involved 332 adults with obesity, grouped by BMI. Researchers measured waist size, hip size, height, and blood markers to see which combination best predicted metabolic syndrome—a cluster of conditions that raise heart disease and diabetes risk. The study did…

This study looked at 26 adults with metabolic syndrome to see if a 12-month lifestyle program could lower body fat and change certain gene markers. Participants tracked their diet and activity using a mobile app, and had blood tests and body scans at the start and end. The goal w…

This study looked at whether a weight loss program led by local community members (called House Chat Leaders) could work in a real-world setting. It involved 71 African American adults from Petersburg, VA, who were interested in making healthy lifestyle changes. The goal was to s…

This study looked at 101 adults who had weight-loss surgery to see if changes in taste and smell are linked to 'hedonic hunger' — the urge to eat for pleasure, not just fuel. Participants filled out questionnaires about their senses, diet quality, and physical activity. The goal …

This study looked at whether four simple nudges—like showing sugar content or health warnings—could encourage college students to pick sugar-free drinks instead of sugary ones. Over 1,600 students took part in menu-choice tasks. The goal was to see which nudge works best for prom…

This study looked at how bariatric surgery affects taste receptors and taste perception in 20 obese patients. Researchers measured changes in taste before and 6 months after surgery. The goal was to understand why taste changes happen after weight loss surgery.

This study tested whether a blood marker called PTX3 can predict how well people with obesity respond to gastric bypass surgery. Researchers followed 23 adults for 6 months after surgery, measuring weight loss, inflammation, and insulin resistance. The goal was to see if PTX3 lev…

This study looked at how a short-term high-fat diet (5 days) compared to a low-fat diet (5 days) affects inflammation in older adults aged 50-79, both with normal weight and obesity. Researchers measured blood markers of inflammation and gut bacteria changes. The goal was to unde…

This study looked at the bacteria living in the small intestine and colon of 90 adults, including lean individuals, people with obesity, and those with both obesity and type 2 diabetes. Researchers collected samples during routine endoscopy or colonoscopy to compare gut bacteria …

This study tested two different forms of an experimental drug (NNC0519-0130) in 46 adults with overweight or obesity. The goal was to measure how much of each version gets into the blood, not to treat the condition. Participants received both versions by chance over about 24 week…

This pilot study tested different outreach methods to encourage blood sugar screening in 102 overweight adults who had not been tested recently. The goal was to find undiagnosed prediabetes or type 2 diabetes earlier. Researchers compared how well each approach worked and how acc…

This study looked at how the drug GZR18 is processed and eliminated from the body in 6 overweight or obese Chinese men. Participants took a single dose with a radioactive label, and researchers measured the drug and its breakdown products in blood, urine, and stool over about 11 …

This study looked at how two different but equally healthy diet plans affect insulin levels and other markers of metabolic health in people who are overweight or at risk for diabetes. Researchers measured changes in blood sugar, cholesterol, and metabolism in 52 adults. The goal …

This study looked at how moderate physical activity influences the way the body processes different types of dietary fats in men with obesity. Twelve men aged 18 to 55 with a BMI over 25 and a sedentary lifestyle participated. They underwent tests before and after two months of e…

This study looked at how often serious and non-serious side effects happen in Mexican patients taking Saxenda for obesity. Researchers tracked 27 patients to catch cases of pancreatitis and other possible drug reactions early. The goal was to improve safety monitoring, not to tes…

This study followed 37 adults who were about to start a GLP-1 medication (like Ozempic or Mounjaro) for weight or diabetes management. Researchers tracked their eating habits, side effects, and medication use over time. The goal was to see if it's possible to collect this kind of…

This study tested whether teaching women about the Mediterranean diet and sustainable eating could improve their body composition, like weight and body fat. 62 women with overweight or obesity took part. The goal was to see if this education leads to healthier eating habits and b…

This study looked at how high-intensity interval training (HIIT) and weight-loss surgery affect nerve health in people with obesity. Researchers measured nerve fiber density in the skin and used eye scans to track nerve changes. The goal was to see if these interventions could lo…

This study collected tissue from the neck, along with blood and urine samples, from 34 adults undergoing neck surgery. The samples are stored in a central bank for future research on obesity and diabetes. No treatments or interventions were tested.

This study looked at how long-term lack of sleep affects heart health and weight in women. Researchers compared women before and after menopause to see if sleep loss leads to higher blood pressure, worse blood sugar control, and more belly fat. The goal was to understand these ri…

This study examined how often adults with obesity in the Gulf region have related health problems like diabetes, high blood pressure, and fatty liver disease. Researchers also looked at the medical costs and healthcare use for these conditions. The study involved 1,316 adults and…

This study looked at whether MRI can accurately detect brown adipose tissue (brown fat) in healthy adults, using PET scans as the gold standard. Eight volunteers were imaged under mild cold conditions. The goal was to see how well MRI maps overlap with PET maps. This is a knowled…

This study looked at how the drug dupilumab changes genes and proteins in airway cells from adults with allergic asthma and obesity (BMI 30 or higher). Researchers collected nasal cells from 28 participants and tested them in the lab to understand how dupilumab affects inflammati…

This completed study looked at how different patterns of body fat—too much, too little, or unevenly distributed—affect insulin resistance and the immune system. Researchers measured various immune markers, especially interleukin-7, in 126 adults with obesity, lipodystrophy, or ty…

This study analyzed genetic data from 2,500 people who had bariatric surgery to see if certain genes are linked to better weight loss outcomes. The goal was to find out if these genetic factors differ among ethnic groups. No new treatment was tested; instead, researchers looked a…

This study tested whether a ketone supplement can alter appetite-related hormones in adults with obesity compared to those without. Twenty-six participants received either a ketone drink or a placebo with a meal, and researchers measured hunger and fullness hormones over several …

This study looked at how obesity changes muscle fiber types and protein production. Researchers measured how fast muscles make new proteins in 48 lean and obese adults. They used exercise and amino acid infusions to see how these factors affect muscle health. The goal was to unde…

This study looked at how being treated unfairly because of weight affects health habits. 330 adults with a BMI of 28 or higher were randomly assigned to experience weight stigma or not. Researchers then measured their eating, physical activity, and sleep over several days to see …

This study followed 1,100 adults with severe obesity who were taking the weight-loss drug WEGOVY. Researchers tracked weight changes over 12 months and looked for patterns in who responded best. They also used artificial intelligence to find which factors—like eating habits or bl…

This study looked at whether taking an anti-nausea medication (ondansetron) changes the amount of AMG 133 in the blood of people who are overweight or obese. 59 adults took AMG 133 alone or with the anti-nausea drug. The goal was to measure drug levels and check for side effects,…

This study looked at whether adding a patient coach could help older adults with obesity stick to their weight and health plan. 19 participants were given a coach to support them with diet, physical therapy, and community resources. The goal was to see if coaching improved attend…

This study looked at how obesity affects the way the body processes immunoglobulin G (IgG), a drug used to treat immune deficiency. Researchers wanted to find the best dose for obese patients to avoid side effects from too much medication. The study included 40 adults aged 18 to …

This study aims to understand why obesity leads to obstructive sleep apnea in some people but not others. Researchers will measure airway collapse and muscle responses during sleep in 106 adults with obesity, both with and without sleep apnea. Participants will be studied before …

This study looked at how sleep quality, when people eat, and gut bacteria are connected to obesity. It included 133 adults with different body weights and sleep issues. The goal was to understand these links and test a simple e-health tool to help people make healthier lifestyle …

This early-stage study looked at how a low-fat meal and taking the drug in the evening change the way KAI-7535 moves through the body. It involved 18 healthy adults who were overweight or obese. The goal was to gather information for future dosing instructions, not to treat or cu…

This study looked at 290 people who had sleeve gastrectomy surgery for obesity. Researchers wanted to see how what they ate during the first year after surgery affected their weight loss. The main goal was to measure changes in body mass index (BMI) one year after the operation.

This study followed 42 adults with spinal cord injury for one year after leaving rehab. Researchers tracked what they ate, how active they were, and factors like mood and kitchen access to understand why weight gain happens. The goal is to use this information to design better he…

This study looked at how a 20% calorie-restricted diet changes metabolism in obese men of two age groups: 30-40 and 60-70 years old. Researchers measured fat breakdown at rest and during exercise, along with other metabolic and genetic markers. The goal was to understand if older…

This study examined 20 women undergoing large-volume liposuction (5-8 liters) to see if the size of the treated body area affects blood counts, clotting, and electrolyte levels. Researchers compared patients who had liposuction on different surface areas. The goal was to better u…

This study looked back at the records of over 9,000 people who had weight-loss (bariatric) surgery. The goal was to find what factors might increase the risk of bleeding during or within 30 days after surgery. By identifying these predictors, doctors hope to create a scoring syst…

This study looked at how salt in the diet affects blood pressure in Black adults. 19 participants ate both high-salt and low-salt diets to see how their bodies handled salt. The goal was to understand the link between salt and blood pressure, not to test a treatment.

This early-stage study tested a single dose of a new medicine, NNC0662-0419, in 100 adults with overweight or obesity. Researchers wanted to see how the drug behaves in the body and whether it is safe in Japanese, Chinese, and non-Asian participants. The study lasted up to 2 mont…

This study looked at why people have trouble sticking to a diet and exercise plan during a weight loss program. Researchers used smartphone surveys and Fitbits to track 119 adults with overweight or obesity. The goal was to find out what causes these slip-ups in daily life, so fu…

This study looked at how the body processes the antiviral drug acyclovir in people with obesity compared to those without. Researchers tested a special dosing formula based on adjusted body weight. About 13 hospitalized patients had blood drawn multiple times over 12 hours to mea…

This study looked at whether women with obesity perceive sounds they make themselves as quieter than sounds made by others, compared to healthy-weight women. 37 women completed a listening task where they compared the loudness of tones they triggered versus tones triggered by the…

This study looked at what happens inside the body when people with obesity stop following restrictive diets. Researchers measured changes in mitochondria (the cell's energy centers) and gut bacteria after participants returned to normal eating. The goal was to understand why diet…

This study aimed to understand why some people gain or lose weight more easily than others. Researchers measured how participants' bodies burned calories during periods of controlled overeating and fasting. The goal was to see if these measurements could predict an individual's w…