Massive Pre-Diabetes study seeks clues to stop type 2 diabetes
NCT ID NCT00340132
First seen Jun 26, 2026 · Last updated Sep 15, 2026 · Updated 8 times
Summary
This completed study looked at 1759 adults aged 18-55 to uncover why some people develop type 2 diabetes. Researchers measured how the body handles sugar, uses energy, and stores fat, and also collected genetic samples. The goal was to find genetic and lifestyle factors that lead to insulin resistance and diabetes, which could help predict and prevent the disease in the future.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this research could identify genetic markers and environmental factors that predict type 2 diabetes, potentially guiding future prevention strategies.
- What could go wrong
- This is an observational study, not a treatment trial, so it will not directly benefit participants. Findings may not lead to immediate clinical applications.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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1,759 people
The number who actually took part.
- Started
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Jan 1983
- Lead sponsor
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A government research agency
The lead sponsor is the US National Institutes of Health.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Community sample from eligible participants from greater Phoenix metropolitan area@@@@@@
- Ages
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18 to 55 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
* INCLUSION CRITERIA: Subjects from all racial and ethnic backgrounds will be invited to participate if they are: * Ages: 18-55 years old (up to 2200 participants) * Gender: male or female EXCLUSION CRITERIA: Subjects will be excluded who are: * Taking medication for a chronic illness. * Have any acute or chronic diseases or conditions not specifically mentioned that in the opinion of the provider may interfere with the study or decrease safety for participation will be considered exclusionary. * Women who currently pregnant or breastfeeding. * Positive for drug and/or nicotine use. All medications and alcohol consumption are to be stopped for two weeks prior to admission. A urine drug-screening test for drugs such as narcotics, marijuana, and barbiturates will be performed on everyone to exclude from the study people whose urine show active or recent drug use. A positive drug test could confound the results of the study in an unpredictable manner. The results of this test will become a part of the patient s medical records and may be released if requested (please see page 6 of the consent for details regarding medical records release).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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NIDDK, Phoenix
Phoenix, Arizona, 85004, United States
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