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New combo therapy targets both joint pain and obesity in PsA patients

NCT ID NCT06588296

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether adding a weight-loss drug (tirzepatide) to a standard arthritis drug (ixekizumab) helps people with psoriatic arthritis who are overweight or obese. 279 adults with active psoriatic arthritis and a BMI of 27 or higher took part. The goal was to see if the combination improved joint symptoms and led to at least 10% weight loss better than the arthritis drug alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

279 people

The number who actually took part.

Started

Sep 2024

Finished

Apr 2026

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have signs and/or symptoms or documented diagnosis of Psoriatic Arthritis (PsA) for at least 6 months and currently fulfilling the classification of Psoriatic Arthritis (CASPAR) criteria. * Have active PsA, defined as the presence of at least 3 of 68 tender joints and at least 3 of 66 swollen joints. * Have obesity, body mass index of ≥30 kilograms per meter squared (BMI ≥30 kg/m²) or overweight (BMI ≥27 to \<30 kg/m²) in the presence of at least 1 of these weight-related comorbid conditions (hypertension, dyslipidemia, obstructive sleep apnea, cardiovascular disease, or T2DM). Exclusion Criteria: Medical Conditions * Have Type 1 Diabetes Mellitus (T1DM). * Have insulin-treated Type 2 Diabetes Mellitus (T2DM). * Have a prior or planned surgical treatment for obesity. * Have a family or personal history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia (MEN) syndrome type 2. * Have active, or a history of inflammatory bowel disease (Crohn's or ulcerative colitis). * Have a diagnosis or history of malignant disease within the 5 years prior to randomization, with the following exceptions: * basal cell or squamous epithelial carcinomas of the skin that have been resected, with no evidence of metastatic disease for 3 years. * cervical carcinoma in situ, with no evidence of recurrence within the 5 years prior to randomization. * Have a serious disorder or illness other than PsA. * Have a history of chronic or acute pancreatitis. * Have any prior use of ixekizumab or tirzepatide. * Diagnosis of other inflammatory arthritis, such as Rheumatoid Arthritis (RA), ankylosing spondylitis, reactive arthritis, gout, or enteropathic arthritis. * Have a previous failure or intolerance to an interleukin 17 inhibitor (IL-17i) or glucagon-like peptide 1 (GLP-1) receptor agonists.

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Conditions

The condition(s) this trial relates to.

Obesity obesity disorder psoriatic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity Psoriatic arthritis

Contacts and locations

Locations

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Avondale

    Avondale, Arizona, 85392, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Chandler

    Chandler, Arizona, 85225, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Flagstaff

    Flagstaff, Arizona, 86001, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Gilbert

    Gilbert, Arizona, 85297, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Glendale

    Glendale, Arizona, 85306, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Mesa

    Mesa, Arizona, 85210, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Phoenix PV

    Phoenix, Arizona, 85032, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Sun City

    Sun City, Arizona, 85351, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Tucson

    Tucson, Arizona, 85704, United States

  • AARA Clinical Research - Arizona Arthritis & Rheumatology Associates - Tucson Southeast

    Tucson, Arizona, 85748, United States

  • AARA Clinical Research - Kansas City Physician Partners - North

    Kansas City, Missouri, 64151, United States

  • AARA Clinical Research - Lone Star Arthritis and Rheumatology Associates - Fort Worth

    Fort Worth, Texas, 76109, United States

  • AARA Clinical Research - Lone Star Arthritis and Rheumatology Associates - Irving

    Irving, Texas, 75039, United States

  • AARA Clinical Research - Murfreesboro Medical Clinic

    Murfreesboro, Tennessee, 37128, United States

  • Accurate Clinical Management, LLC

    Baytown, Texas, 77521, United States

  • Accurate Clinical Research, Inc

    Lake Charles, Louisiana, 70605, United States

  • Accurate Clinical Research, Inc

    Houston, Texas, 77089, United States

  • Advanced Rheumatology of Houston - Woodlands

    The Woodlands, Texas, 77382, United States

  • Advanced Rheumatology, PC

    Okemos, Michigan, 48864, United States

  • Albuquerque Center for Rheumatology

    Albuquerque, New Mexico, 87102, United States

  • Alliance for Multispecialty Research, LLC

    Wichita, Kansas, 67207, United States

  • Altoona Center For Clinical Research

    Duncansville, Pennsylvania, 16635, United States

  • Arnold Arthritis & Rheumatology

    Skokie, Illinois, 60076, United States

  • Arthritis Care of Texas

    Corpus Christi, Texas, 78415, United States

  • Arthritis Consultants, Inc.

    St Louis, Missouri, 63141, United States

  • Arthritis Northwest, PLLC

    Spokane, Washington, 99204, United States

  • Atlanta Research Center for Rheumatology

    Marietta, Georgia, 30060, United States

  • Biopharma Informatic, LLC

    Katy, Texas, 77494, United States

  • Caribbean Medical Research Center

    San Juan, 00918, Puerto Rico

  • Centro Reumatologico Caguas

    Caguas, 00725, Puerto Rico

  • Clinical Research of West Florida

    Tampa, Florida, 33606, United States

  • Clinical Research of West Florida, Inc. (Clearwater)

    Clearwater, Florida, 33765, United States

  • Clinvest Headlands Llc

    Springfield, Missouri, 65807, United States

  • Cohen Medical Centers

    Thousand Oaks, California, 91360, United States

  • Conquest Research

    Winter Park, Florida, 32789, United States

  • DM Clinical Research - TRA

    Tomball, Texas, 77375, United States

  • Denver Arthritis Clinic

    Denver, Colorado, 80230, United States

  • Essential Medical Research

    Tulsa, Oklahoma, 74137, United States

  • GCM Medical Group, PSC - Hato Rey Site

    San Juan, 00917, Puerto Rico

  • Great Lakes Clinical Trials - Ravenswood

    Chicago, Illinois, 60640, United States

  • Greater Chicago Specialty Physicians

    Schaumburg, Illinois, 60195, United States

  • Inspire Santa Fe Medical Group

    Santa Fe, New Mexico, 87505, United States

  • International Center for Research

    Tampa, Florida, 33614, United States

  • Jacksonville Center for Clinical Research

    Jacksonville, Florida, 32216, United States

  • Klein & Associates, M.D., P.A.

    Cumberland, Maryland, 21502, United States

  • Klein & Associates, M.D., P.A.

    Hagerstown, Maryland, 21740, United States

  • Life Clinical Trials

    Margate, Florida, 33063, United States

  • Logan Health Research

    Kalispell, Montana, 59901, United States

  • Medvin Clinical Research - Apple Valley

    Apple Valley, California, 92307, United States

  • Medvin Clinical Research - Covina

    Covina, California, 91722, United States

  • Medvin Clinical Research - Riverside

    Riverside, California, 92508, United States

  • Medvin Clinical Research - Temecula

    Temecula, California, 92592, United States

  • Medvin Clinical Research - Tujunga

    Tujunga, California, 91042, United States

  • Medvin Clinical Research - Whittier

    Whittier, California, 90602, United States

  • Mindful Medical Research

    San Juan, 00918, Puerto Rico

  • NECCR PrimaCare Research

    Fall River, Massachusetts, 02721, United States

  • NeoClinical Research

    Hialeah, Florida, 33016, United States

  • Newport Huntington Medical Group

    Huntington Beach, California, 92648, United States

  • Onsite Clinical Solutions, LLC - Brenner Ave

    Salisbury, North Carolina, 28144, United States

  • Overlake Arthritis and Osteoporosis Center

    Bellevue, Washington, 98004, United States

  • Paramount Medical Research & Consulting, LLC

    Middleburg Heights, Ohio, 44130, United States

  • Physician Research Collaboration, LLC

    Lincoln, Nebraska, 68516, United States

  • Precision Comprehensive Clinical Research Solutions - Colleyville

    Colleyville, Texas, 76034, United States

  • Purushotham & Akther Kotha MD, Inc

    La Mesa, California, 91942, United States

  • Qualmedica Research, LLC

    Evansville, Indiana, 47715, United States

  • RAO Research LLC

    Oklahoma City, Oklahoma, 73116, United States

  • Research Physicians Network, LLC

    Houston, Texas, 77089, United States

  • Reuviva Research Center

    Guaynabo, 00968, Puerto Rico

  • Rheumatology & Pulmonary Clinic

    Beckley, West Virginia, 25801, United States

  • Rheumatology Center of San Diego

    San Diego, California, 92128, United States

  • Saint Paul Rheumatology

    Eagan, Minnesota, 55121, United States

  • Sarasota Arthritis Center

    Sarasota, Florida, 34239, United States

  • South Florida Rheumatology

    Hollywood, Florida, 33021, United States

  • SouthWest Rheumatology Research, LLC

    Mesquite, Texas, 75150, United States

  • Southeastern Rheumatology Alliance dba Arthritis Center of North Georgia

    Gainesville, Georgia, 30501, United States

  • St. Lawrence Health System

    Canton, New York, 13617, United States

  • St. Luke's Clinic

    Boise, Idaho, 83702, United States

  • Summit Headlands

    Portland, Oregon, 97210, United States

  • Suncoast Clinical Research, Inc.

    New Port Richey, Florida, 34652, United States

  • Tekton Research, LLC.

    Austin, Texas, 78745, United States

  • Valley Arthritis Center

    McAllen, Texas, 78501, United States

  • Vida Clinical Research

    Kissimmee, Florida, 34741, United States

  • Vitalia Medical Research

    Palm Beach Gardens, Florida, 33410, United States

  • West Tennessee Research Institute

    Jackson, Tennessee, 38305, United States

  • West Texas Clinical Research

    Lubbock, Texas, 79424, United States

  • Willow Rheumatology and Wellness PLLC

    Willowbrook, Illinois, 60527, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.