PSORIATIC ARTHRITIS

This study tests whether taking fecal transplants (processed stool from healthy donors) in capsule form can help control inflammation in people newly diagnosed with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's disease, or ulcerative colitis. Two hund…

This study tests a new daily pill, zasocitinib (TAK-279), for people with active psoriatic arthritis, a condition causing joint pain and skin patches. About 600 adults will receive either the drug or a placebo for up to 60 weeks to see if it improves symptoms like joint swelling …

This study tests whether upadacitinib, a daily pill, can reduce inflammation and improve symptoms in people with active psoriatic arthritis that also affects the spine. About 100 adults who have not responded well to standard treatments will receive either upadacitinib or a place…

This study looks at how long people with psoriatic arthritis (a condition causing joint pain and skin issues) continue taking risankizumab compared to other advanced medications. About 1,200 participants across 15 countries will be followed for 24 months during their regular doct…

This study tests an experimental drug called SPY002-072 in 285 adults with moderately to severely active rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis. Participants receive either the drug or a placebo to see if it reduces joint pain, swelling, and inflamm…

This study tests whether switching to guselkumab (a drug that blocks IL-23) is better than switching to another TNF inhibitor (golimumab) for people with psoriatic arthritis whose first TNF inhibitor didn't work well enough. About 63 adults with active psoriatic arthritis will be…

This study tests two drugs (risankizumab and lutikizumab), alone or together, in 120 adults with active psoriatic arthritis—a condition causing joint pain and swelling. Participants are randomly assigned to one of three treatment groups. The goal is to see if these targeted thera…

This study tests a new drug called picankibart for people with active psoriatic arthritis, a condition causing joint pain and skin patches. About 222 adults will get either the drug or a placebo as a shot under the skin. The goal is to see if the drug improves joint symptoms and …

This study tests a new oral drug called zasocitinib (TAK-279) for adults with active psoriatic arthritis who have not tried biologic treatments. About 1,088 participants will receive either the new drug, an active comparator, or a placebo for up to 60 weeks. The main goal is to s…

This study compares two ways of giving bimekizumab—an IV infusion versus a standard shot—to see if the IV works just as well. About 392 adults with active psoriatic arthritis or axial spondyloarthritis will take part. The main goal is to check drug levels in the blood and watch f…

This study looks at whether adding tirzepatide (a weight-loss drug) to standard ixekizumab therapy helps adults with active psoriatic arthritis who are overweight or obese. About 200 participants will receive the combination for up to 12 months. The main goals are to see if more …

This study looks at the long-term safety and effectiveness of the drug zasocitinib for adults with psoriatic arthritis, a condition causing joint pain and skin problems. About 1,182 people who completed a one-year study on this drug can join and take it daily for up to two more y…

This study is for people who have both an autoimmune disorder (like rheumatoid arthritis, lupus, or multiple sclerosis) and advanced cancer that has spread or cannot be removed. It tests a drug called nivolumab, which helps the immune system fight cancer, given alone or with othe…

This study tests whether adding two simple questions about morning stiffness and lower back pain to a standard screening tool can help doctors spot psoriatic arthritis earlier in people with moderate-to-severe plaque psoriasis. About 502 adults in Canada who are candidates for bi…

This study tests an online health program that teaches diet and self-care habits to 200 adults with conditions like rheumatoid arthritis, lupus, or psoriatic arthritis. The goal is to see if the program can reduce fatigue and improve quality of life. Participants will complete su…

This study tests a new medicine called tulisokibart for people with active psoriatic arthritis, a condition causing joint pain, swelling, and skin plaques. About 140 adults will receive either the study drug or a placebo to see if it improves symptoms like tender joints and disab…

This study is testing a new educational tool designed for people with melanoma who also have an autoimmune disease (like rheumatoid arthritis or Crohn's disease). The tool helps patients understand immune checkpoint inhibitor drugs and their possible side effects. Researchers wil…

This study is creating a large database and biobank from 2200 people with chronic inflammatory diseases like lupus, multiple sclerosis, and severe asthma. Researchers will track disease activity, quality of life, and treatment responses over time. The goal is to find new markers …

This study is building a large collection of health information and blood samples from 5,000 adults with rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers will use this data to find links between patient outcomes and biological markers. The goal is…

This study looks at tissue samples from painful Achilles tendons of 30 people with psoriatic arthritis who have tendon inflammation (enthesitis). Researchers want to find out which immune cells and inflammatory markers are present, since these are not well understood. The goal is…

This study looks at how much of the drug bimekizumab passes into the breast milk of mothers who are already taking it for conditions like psoriasis or arthritis. About 20 breastfeeding women will provide milk samples over several weeks. The goal is to understand possible exposure…

This study is creating a biobank of blood and tissue samples from 2,000 people with rheumatoid arthritis, psoriatic arthritis, spondyloarthritis, or osteoporosis. Researchers will analyze these samples to find biological markers that can predict how well a patient will respond to…