Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New drug combo aims to tame psoriatic arthritis pain

NCT ID NCT06865105

Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests two injectable drugs, lutikizumab and risankizumab, alone or together, in 120 adults with active psoriatic arthritis. The goal is to see if they can reduce joint pain, swelling, and other symptoms. Participants will be randomly assigned to one of three treatment groups and monitored for side effects and improvement over time.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Lutikizumab and risankizumab (injectable drugs)
What this could lead to
If successful, this could point toward a new combination treatment that better controls joint pain and swelling in psoriatic arthritis.
What could go wrong
This is an early Phase 2 study with only 120 participants, so results may not apply to everyone. Side effects are possible, and the combination may not work better than existing options.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2025

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participant is willing and able to comply with procedures required in the Master Protocol and substudies. * Participant has a documented clinical diagnosis of PsA with symptom onset at least 6 months prior to the Screening Visit and fulfillment of the Classification Criteria for Psoriatic Arthritis (CASPAR) at Screening Visit. * Participant has active disease defined as greater than or equal to 3 tender joints (based on 68 joint count) and greater than or equal to 3 swollen joints (based on 66 joint count) at both the Screening Visit and Baseline. * Participant has active plaque PsO and/or a documented history of plaque PsO. * Participant must demonstrate intolerance or inadequate response to 1 to 2 targeted therapies (biologic or targeted synthetic disease-modifying antirheumatic drugs) approved for the treatment of PsA Exclusion Criteria: * Participants who have had major surgery performed within 12 weeks prior to randomization or plan to have a major surgery during conduct of the study (e.g., aneurysm removal, stomach ligation). * Participants with the following chronic or active infections: Are infected with human immunodeficiency virus (HIV), active hepatitis B virus (HBV) or hepatitis C virus(HCV) infection, active tuberculosis(TB) * Active skin disease other than psoriasis (PsO) which could interfere with the assessment of PsO. * History of fibromyalgia, any arthritis with onset prior to age 17 years, or current diagnosis of inflammatory joint disease other than psoriatic arthritis (PsA) (including but not limited to rheumatoid arthritis, gout, overlap connective tissue diseases, scleroderma, polymyositis, dermatomyositis, systemic lupus erythematosus).

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Psoriatic arthritis are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

psoriatic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Psoriatic arthritis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    36 sites in 6 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Accurate Clinical Research - Houston /ID# 272754

    RECRUITING

    Houston, Texas, 77089-6142, United States

  • Altoona Center For Clinical Research /ID# 272593

    RECRUITING

    Duncansville, Pennsylvania, 16635, United States

  • Borsod-Abauj-Zemplen Varmegyei Kozponti Korhaz es Egyetemi Oktatokorhaz /ID# 272572

    RECRUITING

    Miskolc, Borsod-Abauj Zemplen county, 3529, Hungary

  • CHU Bordeaux - Hopital Pellegrin /ID# 273390

    RECRUITING

    Bordeaux, New Aquitaine, 33076, France

  • Centre Hospitalier Régional Universitaire De Tours - Hôpital Trousseau /ID# 272762

    RECRUITING

    Chambray-lès-Tours, Indre-et-Loire, 37170, France

  • Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 272877

    RECRUITING

    Orléans, 45067, France

  • Centre Hospitalier Universitaire de Nice - Hopital Pasteur /ID# 272771

    RECRUITING

    Nice, Alpes-Maritimes, 06001, France

  • Centre de Recherche Musculo-Squelettique /ID# 274397

    RECRUITING

    Trois-Rivières, Quebec, G9A 3X2, Canada

  • Centrum Kliniczno-Badawcze J.Brzezicki, B. Gornikiewicz-Brzezicka Lekarze Spolka /ID# 273306

    RECRUITING

    Elblag, Warmian-Masurian Voivodeship, 82-300, Poland

  • Centrum Medyczne Reuma Park /ID# 273301

    RECRUITING

    Warsaw, Masovian Voivodeship, 02-665, Poland

  • Clinic Of Dr. Robert Hozman/Clinical Investigation Specialists, Inc /ID# 272879

    RECRUITING

    Skokie, Illinois, 60076, United States

  • Clinical Research Of West Florida - Phase I Unit /ID# 273198

    RECRUITING

    Clearwater, Florida, 33765, United States

  • Clinical Research Of West Florida - Tampa - North Howard Avenue /ID# 273199

    RECRUITING

    Tampa, Florida, 33606, United States

  • Complex Rendelo Med Zrt. /ID# 272570

    RECRUITING

    Székesfehérvár, Fejér, 8000, Hungary

  • Dr. Latha Naik Medical Professional Corporation /ID# 272803

    RECRUITING

    Saskatoon, Saskatchewan, S7H 0P4, Canada

  • Dynamed Clinical Research - Tomball /ID# 272760

    RECRUITING

    Tomball, Texas, 77375, United States

  • HMD Research LLC /ID# 273086

    RECRUITING

    Orlando, Florida, 32819, United States

  • Highlands Advanced Rheumatology And Arthritis Center - Avon Park /ID# 273085

    RECRUITING

    Avon Park, Florida, 33825, United States

  • Infirmerie Protestante De Lyon /ID# 273731

    RECRUITING

    Caluire-et-Cuire, Auvergne-Rhône-Alpes, 69300, France

  • Klein And Associates /ID# 272829

    COMPLETED

    Hagerstown, Maryland, 21740, United States

  • L.K.N. Arthrocentrum /ID# 272366

    RECRUITING

    Hlučín, Moravian-Silesian Region, 748 01, Czechia

  • MCBK S.C. Iwona Czajkowska Anna Podrazka-Szczepaniak /ID# 273305

    RECRUITING

    Pruszków, Masovian Voivodeship, 05-800, Poland

  • Medical Plus s.r.o. /ID# 272363

    RECRUITING

    Uherské Hradiště, 686 01, Czechia

  • Mics Centrum Medyczne Bydgoszcz /ID# 273297

    RECRUITING

    Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-068, Poland

  • Newport Huntington Medical Group /ID# 272764

    RECRUITING

    Huntington Beach, California, 92648-5994, United States

  • Osteo Medic s.c. Artur Racewicz Jerzy Supronik /ID# 273304

    RECRUITING

    Bialystok, Podlaskie Voivodeship, 15-351, Poland

  • PV Medical Services s.r.o. /ID# 272368

    RECRUITING

    Zlín, 760 01, Czechia

  • Paramount Medical Research and Consulting /ID# 272757

    RECRUITING

    Middleburg Heights, Ohio, 44130, United States

  • Private Practice - Dr. Ramesh C. Gupta I /ID# 272897

    RECRUITING

    Memphis, Tennessee, 38119, United States

  • Revita Reumatologiai Rendelo (Revita Kft.) /ID# 272857

    RECRUITING

    Budapest, 1027, Hungary

  • Revmatologie /ID# 272367

    RECRUITING

    Brno, Brno-mesto, 638 00, Czechia

  • Semmelweis Egyetem Reumatológiai és Immunológiai Klinika /ID# 273195

    RECRUITING

    Budapest, 1023, Hungary

  • Tekton Research - West Gate /ID# 272765

    RECRUITING

    Austin, Texas, 78745, United States

  • Tekton Research, LLC /ID# 272901

    RECRUITING

    San Antonio, Texas, 78251, United States

  • Vital-Medicina Kft. /ID# 272855

    RECRUITING

    Veszprém, Fejér, 8200, Hungary

  • West Broward Rheumatology Associates /ID# 272892

    RECRUITING

    Tamarac, Florida, 33321, United States

  • Willow Rheumatology and Wellness, PLLC /ID# 277354

    RECRUITING

    Willowbrook, Illinois, 60527, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.