Can exercise change how your body handles dietary fat?
NCT ID NCT00434265
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how a two-month exercise program changes the way the body processes different types of dietary fats in men with obesity. Twelve men aged 18 to 55 who were overweight but not extremely obese took part. Researchers measured fat oxidation and gene expression in muscle and fat tissue to understand how exercise might shift fat away from storage and toward burning for energy.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- physical training (exercise program)
- What this could lead to
- If successful, this could help explain how exercise influences fat burning and storage, potentially leading to better diet and exercise recommendations for weight management.
- What could go wrong
- This is a very small, early-stage study with only 12 participants, so results may not apply to everyone. It is designed to gather knowledge, not to test a treatment.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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12 people
The number who actually took part.
- Start date
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Mar 2007
- Finished
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Aug 2011
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 55 years
- Sex
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Male participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Men between 18 and 55 * IMC \>25 and \<30 kg/m2 and waist circumference \>102 cm * Familial antecedents of obesity * Physical inactivity (PAL\<1.5, according to MOSPA-questionnaire and accelerometry) * Acceptation of physical training and body weight control during the study Exclusion Criteria: * Any drug interfering with energetic or lipid metabolism * Any contradiction to moderate physical training * Diabetes or arterial hypertension treatment * Any other pathology (cardiovascular, psychiatric, renal or hepatic disease, viral hepatitis or VIH) * Consumption of more than 40 g alcohol per day * Recent voluntary or involuntary weight modification (3kg the next three months) * A recent trip outside France before and during stable isotope measures.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Service de Médecine Interne et de Nutrition - Hôpital de Hautepierre
Strasbourg, 67098, France
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Service des Explorations Fonctionelles Respiratoires et de l'Exercice - Hôpital Civil
Strasbourg, 67091, France
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