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Fasting every other day: could it supercharge your heart?

NCT ID NCT05181267

Knowledge-focused Sponsor: University of Aarhus Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at whether 3 weeks of alternate-day fasting (eating normally one day, fasting the next) changes how the heart uses fuel compared to a typical Western diet. Sixteen overweight adults aged 55-70 with insulin resistance underwent PET scans and lab tests after each diet period. The goal was to see if fasting boosts ketone bodies, which may act as a more efficient fuel for the heart and improve blood flow to the heart and brain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

16 people

The number who actually took part.

Started

Apr 2022

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

55 to 70 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: 55-70 years * BMI: 28-40 kg/m2 Exclusion Criteria: * Any drug that, in the investigator's opinion, may affect the study * HbA1c \> 48 mmol/mol * Known heart failure, previous blood clots, or other heart disease that, in the investigator's opinion, may affect the study, including abnormal ECG and/or echocardiography with evidence of structural heart disease * Liver disease (ALAT \> 3 x of upper normal range), renal failure (eGFR \< 60 ml/min), anaemia (Hb \< 6.5), current or previous malignant disease which, in the investigator's opinion, may affect the study * Current alcohol abuse (\> 21 items per week) * Blood donation within the last 3 months before the study day * Participation in studies/examinations involving radioactive isotopes within the last 6 months * Claustrophobia

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Conditions

The condition(s) this trial relates to.

Insulin Resistance Intermittent Fasting Obesity obesity disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Insulin resistance Obesity

Contacts and locations

Locations

  • Aarhus University Hospital

    Aarhus, Central Jutland, 8200, Denmark

More trials for these conditions

Other studies related to the condition(s) this trial covers.