Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

New daily pill could help people with obesity and diabetes shed pounds

NCT ID NCT05872620

Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Sep 04, 2026 · Updated 2 times

Summary

This phase 3 study tested an experimental once-daily pill called orforglipron (LY3502970) against a placebo in 1613 adults who are overweight or have obesity and type 2 diabetes. The goal was to see if the drug helps with weight loss and improves blood sugar control. Participants took the pill daily for about 77 weeks, and researchers measured changes in body weight, waist size, and blood sugar levels.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Orforglipron (oral medication)
What this could lead to
If successful, this could provide a convenient once-daily pill for weight loss and blood sugar control in people with obesity and type 2 diabetes.
What could go wrong
This is a completed phase 3 trial, but results are not yet public. The drug may cause side effects or not outperform placebo significantly. Long-term safety and effectiveness are still being evaluated.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

1,613 people

The number who actually took part.

Started

Jun 2023

Finished

Aug 2025

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Have a body mass index (BMI) ≥27.0 kilogram/square meter (kg/m²). * Have a history of at least 1 self-reported unsuccessful dietary effort to lose body weight. * Have a diagnosis of Type 2 Diabetes (T2D), with HbA1c ≥7% (≥53 mmol/mol) to ≤10% (86 mmol/mol) and are on stable treatment for T2D for at least 90 days prior to screening, consisting of: * either diet/exercise alone or * up to 3 oral antihyperglycemic medications (excluding dipeptidyl peptidase IV inhibitors (DPP-4i) or glucagon-like peptide-1 (GLP-1) receptor agonists (RA). Exclusion Criteria: * Have Type 1 Diabetes (T1D), history of ketoacidosis or hyperosmolar state/coma, or any other types of diabetes except T2D. * Have a self-reported change in body weight \>5 kg (11 pounds) within 90 days prior to screening. * Are currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema (for example, laser photocoagulation or intravitreal injections of anti-vascular endothelial growth factor inhibitors). * Have family (first-degree relative) or personal history of medullary thyroid cancer (MTC) or multiple endocrine neoplasia 2 (MEN2) syndrome. * Have had a history of chronic or acute pancreatitis.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Obesity are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

Obesity obesity disorder Overweight type 2 diabetes mellitus

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity Overweight Type 2 diabetes

Contacts and locations

Locations

  • 424 Military General Training Hospital

    Thessaloniki, 564 29, Greece

  • AMCR Institute

    Escondido, California, 92025, United States

  • Accellacare - Raleigh

    Raleigh, North Carolina, 27609, United States

  • Advanced Clinical Research, LLC

    Bayamón, PR, 00959, Puerto Rico

  • Advara HeartCare Joondalup

    Joondalup, Western Australia, 6027, Australia

  • Albany Medical College, Division of Community Endocrinology

    Albany, New York, 12203, United States

  • Albany Stratton VA Medical Center

    Albany, New York, 12208, United States

  • All India Institute of Medical Sciences (AIIMS) - Nagpur

    Nagpur, Maharashtra, 441108, India

  • Alliance for Multispecialty Research, LLC

    Knoxville, Tennessee, 37909, United States

  • AmBeNet GmbH

    Leipzig, Saxony, 04107, Germany

  • Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

    Troy, Michigan, 48098, United States

  • Arthur Asirvatham Hospital

    Madurai, Tamil Nadu, 625020, India

  • Arztpraxis Christine Kosch Pirna

    Pirna, Saxony, 01796, Germany

  • Athens Medical Center

    Athens, Attikí, 151 25, Greece

  • Austin Health - Repatriation Hospital

    Heidelberg West, Victoria, 3081, Australia

  • BSES MG Hospital

    Mumbai, Maharashtra, 400058, India

  • Baker IDI Heart and Diabetes Institute - Melbourne

    Melbourne, Victoria, 3004, Australia

  • Balanced Life Health Care Solutions/SKYCRNG

    Lawrenceville, Georgia, 30046, United States

  • Biopharma Informatic, LLC

    Houston, Texas, 77043, United States

  • Box Hill Hospital

    Box Hill, Victoria, 3128, Australia

  • CDG Studienambulanz Hartard

    München, Bavaria, 80809, Germany

  • CEMEDIAB

    C.a.b.a., Ciudad Aut, C1205AAO, Argentina

  • CEPIC - Centro Paulista de Investigação Clínica

    São Paulo, 04266-010, Brazil

  • CONEXA Investigacion Clinica S.A.

    Buenos Aires, 1012, Argentina

  • Cahaba Research - Pelham

    Pelham, Alabama, 35124, United States

  • Catalina Research Institute, LLC

    Montclair, California, 91763, United States

  • Ceda-Research

    Pohlheim, Hesse, 35415, Germany

  • Cendi - Endocrinologia e Diabetes

    Goiânia, Goiás, 74230-035, Brazil

  • Centro Diabetológico Dr. Waitman

    Córdoba, 5000, Argentina

  • Centro de Diagnóstico y Rehabilitación (CEDIR)

    Santa Fe, 3000, Argentina

  • Centro de Investigaciones Médicas Tucuman

    SAN M. de Tucuman, Tucumán Province, T4000AXL, Argentina

  • Centro de Pesquisa Clinica do Brasil

    Brasília, Federal District, 71625-175, Brazil

  • Centro de Pesquisa Clínica de Marília - CPCLIM

    Marília, São Paulo, 17504-072, Brazil

  • Charlottesville Medical Research

    Charlottesville, Virginia, 22911, United States

  • Chinese PLA General Hospital

    Beijing, Beijing Municipality, 100853, China

  • Chongqing General Hospital

    Chongqing, Chongqing Municipality, 400014, China

  • Clínica Universitaria Reina Fabiola

    Córdoba, X50004FHP, Argentina

  • Core Research Group

    Brisbane, Queensland, 4064, Australia

  • Dalian Municipal Central Hospital Affiliated of Dalian Medical University

    Dalian, Liaoning, 116033, China

  • Diabet2 s.r.o., diabetologicka a interni ambulance

    Prague, Praha 1, 11000, Czechia

  • Diabetes Zentrum Dr. Tews

    Gelnhausen, 63571, Germany

  • Diabetes Zentrum Wilhelmsburg

    Hamburg, 21109, Germany

  • Diabetes and Glandular Disease Center

    San Antonio, Texas, 78229, United States

  • Diahelp s.r.o

    Pardubice V, Pardubice, 530 02, Czechia

  • Dialine - Interni a diabetologicka ambulance

    Pilsen, Plzeň-město, 301 00, Czechia

  • East Coast Institute for Research, LLC

    Jacksonville, Florida, 32216, United States

  • Emeritus Research

    Botany, New South Wales, 2019, Australia

  • Emeritus Research

    Camberwell, Victoria, 3124, Australia

  • Encore Medical Research

    Hollywood, Florida, 33024, United States

  • Endocrine Research Solutions, Inc.

    Roswell, Georgia, 30076, United States

  • Endokrinologie MUDr. Rehorkova s.r.o.

    Hradec Králové, 500 12, Czechia

  • Epic Medical Research - DeSoto

    DeSoto, Texas, 75115, United States

  • Euromedica General Clinic of Thessaloniki

    Thessaloniki, Thessaloníki, 546 45, Greece

  • Gemeinschaftspraxis Dr. med. Josef und Wilma Großkopf

    Wallerfing, Bavaria, 94574, Germany

  • Hausarzt- und Diabetologische Schwerpunktpraxis Hohenmölsen - Weiβenfels

    Hohenmölsen, Saxony-Anhalt, 06679, Germany

  • IMA Clinical Research

    Albuquerque, New Mexico, 87109, United States

  • InnoDiab Forschung Gmbh

    Essen, North Rhine-Westphalia, 45136, Germany

  • Institut für Diabetesforschung GmbH Münster

    Münster, Nordrhein-, 48145, Germany

  • Instituto Centenario

    CABA, Ciudad Autónoma de Buenos Aire, 1204, Argentina

  • Instituto Lóbus

    Volta Redonda, Rio de Janeiro, 27253-003, Brazil

  • Instituto Méderi de Pesquisa e Saúde

    Passo Fundo, Rio Grande do Sul, 99010-120, Brazil

  • Instituto Médico Fundación Grupo Colaborativo Rosario Investigación y Prevención Medica

    Rosario, Santa Fe Province, 2000, Argentina

  • Instituto de Investigaciones Clinicas Rosario

    Rosario, Santa Fe Province, 2000, Argentina

  • Instituto de Pesquisa clinica de Campinas

    Campinas, São Paulo, 13060-080, Brazil

  • Iowa Diabetes and Endocrinology Research Center

    West Des Moines, Iowa, 50265, United States

  • Ippokrateio General Hospital of Thessaloniki

    Thessaloniki, Kentrikí Makedonía, 54642, Greece

  • Isis Clinical Research Center

    Guaynabo, PR, 00968, Puerto Rico

  • Jiangsu Province Official Hospital

    Nanjing, Jiangsu, 210008, China

  • Jiangxi Provincial People's Hospital

    Nanchang, Jiangxi, 330006, China

  • Jinan Central Hospital

    Jinan, Shandong, 250013, China

  • Karnataka Institute of Medical Sciences

    Hubli, Karnataka, 580021, India

  • Korea University Anam Hospital

    Seoul, Seoul-teukbyeolsi [Seoul], 02841, South Korea

  • Kumudini Devi Diabetes Research Center

    Hyderabad, Telangana, 500082, India

  • Kyung Hee University Hospital at Gangdong

    Seoul, Seoul-teukbyeolsi [Seoul], 134-090, South Korea

  • Las Vegas Medical Research

    Las Vegas, Nevada, 89128, United States

  • Logan Hospital

    Meadowbrook, Queensland, 4131, Australia

  • MUDr. Alena Vachova

    České Budějovice, South Bohemian Region, 37011, Czechia

  • MUDr. Jitka Zemanová - diabetologie a interna s.r.o.

    Pilsen, 326 00, Czechia

  • MUDr. Sabina Palova

    Jílové u Prahy, Praha-západ, 252 42, Czechia

  • MUDr. Tomas Edelsberger

    Krnov, Moravskosl, 79401, Czechia

  • Mautalen Salud e Investigación

    Buenos Aires, Buenos Aires F.D., C1128AAF, Argentina

  • MedStar Good Samaritan Hospital

    Baltimore, Maryland, 21239, United States

  • Medizentrum Essen Borbeck

    Essen, North Rhine-Westphalia, 45355, Germany

  • Medstar Speciality Hospital

    Bangalore, Karnataka, 560092, India

  • Milan Kvapil s.r.o., Diabetologicka ambulance

    Prague, Praha 4, 14900, Czechia

  • Milan Kvapil s.r.o., Diabetologicka ambulance Pribram

    Příbram, Central Bohemia, 26201, Czechia

  • NYC Research INC

    Long Island City, New York, 11106, United States

  • Nanjing First Hospital

    Nanjing, Jiangsu, 210006, China

  • Nantong First People's Hospital

    Nantong, Jiangsu, 226001, China

  • Nemocnice Cesky Krumlov

    Český Krumlov, 381 01, Czechia

  • North Georgia Clinical Research

    Woodstock, Georgia, 30189, United States

  • Novak Clinical Research - Tucson - North La Cholla Boulevard

    Tucson, Arizona, 85741, United States

  • Pacific Diabetes & Endocrine Center

    Honolulu, Hawaii, 96813, United States

  • Papageorgiou General Hospital of Thessaloniki

    Thessaloniki, Thessaloníki, 564 29, Greece

  • Pesquisare Saude

    Santo André, São Paulo, 09080-110, Brazil

  • RED-Institut GmbH

    Oldenburg in Holstein, Schleswig-Holstein, 23758, Germany

  • ResTrial s.r.o.

    Prague, Praha 8, 18100, Czechia

  • Royal Brisbane and Women's Hospital

    Brisbane, Queensland, 4029, Australia

  • SMO.MD GmbH

    Magdeburg, Saxony-Anhalt, 39120, Germany

  • Sahyadri Super Speciality Hospital

    Pune, Maharashtra, 411004, India

  • Sanatorio San Martin

    Venado Tuerto, Santa Fe Province, 2600, Argentina

  • Seoul National University Bundang Hospital

    Seongnam, Kyǒnggi-do, 13620, South Korea

  • ShenZhen People's Hospital

    Shenzhen, Guangdong, 518020, China

  • Solaris Clinical Research

    Meridian, Idaho, 83646, United States

  • Soma Clinical Trials

    Denison, Texas, 75020, United States

  • South Florida Clinical Research Institute

    Margate, Florida, 33063, United States

  • Southern Adelaide Diabetes & Endocrine Services

    Oaklands Park, South Australia, 5046, Australia

  • StudyMetrix Research

    City of Saint Peters, Missouri, 63303, United States

  • Summit Headlands

    Portland, Oregon, 97210, United States

  • Suncoast Clinical Research, Inc.

    New Port Richey, Florida, 34652, United States

  • TOTALL Diabetes Hormone Institute

    Indore, Madhya Pradesh, 452010, India

  • The AIM Centre / Hunter Diabetes Centre

    Merewether, New South Wales, 2291, Australia

  • The Catholic Univ. of Korea Seoul St. Mary's Hospital

    Seoul, Seoul-teukbyeolsi [Seoul], 06591, South Korea

  • The First Affiliated Hospital of Henan University of Science &Technology

    Luoyang Shi, Henan, 471003, China

  • The First People's Hospital of Yunnan Province

    Kunming, Yunnan, 650034, China

  • The Fourth Affiliated Hospital of Harbin Medical University

    Harbin, Heilongjiang, 150001, China

  • The Second Affiliated Hospital of Nanjing Medical University

    Nanjing, Jiangsu, 210011, China

  • The Second Affiliated Hospital of Zhengzhou University

    Zhengzhou, Henan, 450014, China

  • The Second People's Hospital of Hefei

    Hefei, Anhui, 230011, China

  • Thermi Clinic

    Thessaloniki, Thessaloníki, 570 01, Greece

  • Tianjin Medical University General Hospital

    Tianjin, Tianjin Municipality, 300052, China

  • Tianjin Medical University Zhu Xianyi Memorial Hospital

    Tianjin, Tianjin Municipality, China

  • Topiwala National Medical College & B. Y. L. Nair Charitable Hospital

    Mumbai, Maharashtra, 400008, India

  • Universal Research Group

    Tacoma, Washington, 98405, United States

  • Universitaetsklinikum Koeln

    Cologne, North Rhine-Westphalia, 50937, Germany

  • University Clinical Investigators, Inc.

    Tustin, California, 92780, United States

  • University General Hospital of Larissa

    Larissa, Thessalía, 41110, Greece

  • Universität zu Lübeck - Institut für Endokrinologie und Diabetes

    Lübeck, Schleswig-Holstein, 23562, Germany

  • VIP Trials

    San Antonio, Texas, 78230, United States

  • Velocity Clinical Research, Dallas

    Dallas, Texas, 75230, United States

  • Velocity Clinical Research, Huntington Park

    Huntington Park, California, 90255, United States

  • Velocity Clinical Research, Westlake

    Los Angeles, California, 90057, United States

  • Wuxi People's Hospital

    Wuxi, Jiangsu, 214023, China

  • Yeungnam Univeristy Medical Center

    Gyeongsan-si, Kyǒngsangbuk-do, 42415, South Korea

  • Yonsei University-Wonju Severance Christian Hospital

    Wŏnju, Kang-won-do, 26426, South Korea

  • Yuma Clinical Trials

    Yuma, Arizona, 85364, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.