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New study tests a smarter way to beat the Yo-Yo diet cycle

NCT ID NCT03014414

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared two behavioral weight-loss programs in 321 adults with obesity and elevated blood pressure. One program taught maintenance skills before weight loss, while the other focused on losing weight first. Participants were followed for three years to see who could lose at least 7% of their body weight and keep it off. The goal is to find better ways to sustain weight loss and reduce heart disease risk.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
behavioral weight-management programs (Fun First and Weight Watchers)
What this could lead to
If successful, this could point toward more effective strategies for long-term weight maintenance in people with obesity.
What could go wrong
This is a completed behavioral study, not a drug trial. Results may not apply to everyone, and weight regain is common. The interventions require ongoing effort.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

321 people

The number who actually took part.

Started

Mar 2017

Finished

Jan 2022

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria (BMI): * 27 \<= BMI \< 45 kg/m2 Inclusion Criteria (Elevated Blood Pressure): * Systolic blood pressure between 120-159 mmHg OR diastolic blood pressure between 80-99 mmHg. Can be on \>=1 antihypertensive medications if on stable dose for past 3 months * Systolic blood pressure \<120 mmHg OR diastolic blood pressure \<80 mmHg, if on stable dose of \>=1 antihypertensive medications for past 3 months Exclusion Criteria (Blood Pressure): * Elevated blood pressure: Systolic blood pressure \>=160 mmHg OR diastolic blood pressure \>=100 mmHg Exclusion Criteria (Underlying medical conditions/diseases): * Have had a heart attack, stroke, coronary heart disease, congestive heart failure, or angina * Have had coronary artery bypass surgery or cardiac catheterization such as percutaneous transluminal coronary angioplasty (PTCA), cath or stent placement * Have diabetes * Have medical contraindications to regular, unsupervised physical activity * Have moderate to severe asthma, or chronic obstructive pulmonary disorder (also called emphysema or chronic bronchitis) * Had cancer in the past 5 years (except non-melanoma skin cancer) * Currently under medical care for digestive issues, gastrointestinal distress, abdominal pain, or diarrhea * Had an organ transplant Exclusion Criteria (Medications): * Not stable on medications over the past 3 months (e.g., cholesterol, thyroid, estrogen-hormone, psychiatric) * Currently taking prescription pain medications (e.g., Vicodin, Oxycodone) Exclusion Criteria (Weight and diet related): * Have binge eating disorder or bulimic compensatory symptoms * Currently taking medication designed to lose weight * Have undergone weight-loss surgery (e.g., gastric bypass, lap band) * Have lost \>10 pounds in the past 6 months * Currently in a weight-loss program (e.g., Jenny Craig) * Currently participating in any support groups that focus on weight or eating habits (e.g., Overeaters Anonymous) * Currently on a special diet for a serious health condition * Not willing to discontinue a special diet (e.g., Atkins) Exclusion Criteria (Behavioral related): * Planning to move in the next year * Currently pregnant or planning to be within the next year * Participating in another research study * No regular access to a mobile phone and Internet * Not able to speak, read, or understand English for informed consent * Not willing to be randomized * Did not complete eligibility process successfully or in a timely manner * Staff discretion or judgement * Live within Bay Area (e.g., \~1-hour commute from Stanford research center)

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Stanford University School of Medicine

    Palo Alto, California, 94304, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.