Could a keto diet tame prediabetes inflammation?

NCT ID NCT06911879

Disease control Sponsor: University of Jordan Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether a low-carb, high-fat ketogenic diet with fewer calories can reduce inflammation and improve blood sugar control in prediabetic obese adults aged 18 to 40. Ninety participants were split into three groups: a keto diet, a normal diet with fewer calories, or a normal diet without calorie restriction. The main focus was on changes in blood markers of inflammation and insulin resistance over 12 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: ketogenic diet with caloric restriction
What this could lead to: If successful, this could point toward a dietary approach to reduce inflammation and improve insulin sensitivity in people with prediabetes and obesity.
What could go wrong: This is a small, completed trial with 90 participants, so results may not apply to broader populations. Dietary adherence can be challenging, and the long-term effects of a ketogenic diet are not fully known.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Started

May 2025

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * • Males and females individuals aged 18-40 years * Individuals with a body mass index (BMI) greater than 30 kg/m² and less than 40 kg/m². * Individuals medically diagnosed with prediabetes by a physician prior to enrollment in the study as indicated by hemoglobin A1c (HbA1c) levels between 5.7% and 6.4% (American Diabetes Association, 2024), or HOMA-IR score of greater than 1.8. * Individuals demonstrating a willingness to follow the dietary protocol * Individuals engaging in sedentary physical activity levels Exclusion Criteria: * Individuals diagnosed with any other chronic disease or type 1 and type 2 diabetes mellitus. * Individuals have experienced weight loss of more than 5% in the last three months. * Pregnant or lactating women. * Individuals undergoing any form of drug treatment. * Individuals with a history of major surgery. * Individuals have consumed pro-/pre/symbiotic or antibiotics in the past three months. * Individuals who engage in any form of regular sports activity.

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Conditions

The condition(s) this trial relates to.

Inflammation Insulin Resistance Obesity obesity disorder prediabetes syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Caloric restriction Inflammation biomarkers Insulin resistance Ketogenic diet Metabolic endotoxemia Obesity Prediabetes

Could a keto diet tame prediabetes inflammation?

What the study statuses mean