PREDIABETES

This study looks at whether adding baked potatoes (with skin) to a Mediterranean diet can improve blood sugar control, blood pressure, and cholesterol in adults aged 45-80 with pre-diabetes. Sixty participants will either get diet education alone or education plus pre-prepared ba…

This study tests whether a pharmacist-led program using a continuous glucose monitor (CGM) can help people with prediabetes better control their blood sugar and make healthier choices. Forty adults with prediabetes will wear a CGM sensor for 12 weeks and receive pharmacist guidan…

This study tests a program called Regulation of Cues (ROC) in 30 Latina women with prediabetes and obesity. The program teaches awareness of eating triggers and coping strategies to reduce weight and prevent type 2 diabetes. Researchers are first checking if participants find the…

This study tests whether giving a healthy food voucher to people with type 2 diabetes or prediabetes who have low income can improve their blood sugar control. About 390 participants will be randomly assigned to receive the voucher or not. The main goal is to see if hemoglobin A1…

This pilot study compares two approaches to reduce type 2 diabetes risk in 40 overweight adults with prediabetes. One group follows the standard Diabetes Prevention Program (DPP) focusing on diet and exercise. The other group uses an enhanced version (DPP++) that also includes a …

This study tests a computer program called GlucAlert-CDS that alerts doctors when hospitalized patients have dangerously high or low blood sugar. The tool suggests care recommendations to improve glucose control. Researchers will compare periods when the tool is active versus ina…

This study tests whether a supplement called dihydroberberine (DHB) can improve blood sugar control, appetite, and energy in adults with prediabetes. About 54 participants will take either DHB or a placebo daily for 6 weeks. Researchers will measure blood sugar, insulin, and GLP-…

This study looks at whether adding menopausal hormone therapy (MHT) to a GLP-1 receptor agonist (a type of diabetes drug) helps control blood sugar and weight better than the diabetes drug alone. It involves 96 early postmenopausal women who have or are at risk for type 2 diabete…

This study tests an investigational drug called MOTS-c in 120 adults with prediabetes and overweight or obesity. The goal is to see if 12 weeks of treatment can improve how the body uses insulin, compared to a placebo. All participants also receive standard lifestyle advice. The …

This study compares two newer diabetes drugs, semaglutide and dapagliflozin, against the standard drug metformin in 300 people with pre-diabetes and coronary artery disease. The goal is to see which drug best slows or reverses the buildup of plaque in heart arteries over 24 month…

This study looks at whether increasing physical activity and stopping evening snacking can improve metabolic health in teenagers aged 12-18 who have prediabetes. Participants will be randomly assigned to either follow these lifestyle changes or receive standard care for 8 weeks. …

This study tests a new digital tool that helps doctors create personalized exercise plans for patients with risk factors for heart disease, such as high blood pressure, diabetes, and obesity. The study will involve 24 doctors and 48 patients. Doctors will use the tool for some pa…

This study looks at whether eating peanuts every day can improve blood sugar, blood pressure, thinking skills, and gut health in adults with prediabetes. Researchers will enroll 72 racially diverse adults aged 20-59 who have prediabetes but no peanut allergies. Participants will …

This study tests whether meal replacement products can help low-income adults with obesity and diabetes or pre-diabetes lose weight and lower blood sugar. Twenty participants will use meal replacements and be monitored for weight and A1c changes. The goal is to see if this approa…

This study tests whether a liquid supplement made from carob extract can improve blood sugar control in people with prediabetes. Thirty adults with prediabetes will take either the carob supplement or a placebo before meals for a period of time. Researchers will measure changes i…

This study compares personalized oral hygiene advice from an AI app versus a human dentist in 148 adults with prediabetes and gum disease. The goal is to see if AI can improve gum health and blood sugar levels as effectively as a dentist. Participants will be followed for 9 month…

This study tests whether wearing a continuous glucose monitor (CGM) helps teens with prediabetes stick to healthy lifestyle changes and improve insulin sensitivity. Fifteen overweight or obese teens aged 10–17 with impaired glucose tolerance will wear a Dexcom G7 sensor and recei…

This study provides 400 adults with diabetes or prediabetes who struggle to afford food with free fresh food boxes and nutrition classes twice a month for six months. Researchers will check if this program helps lower blood sugar levels and reduces food insecurity. The goal is to…

This study tests a supplement called Nextida GC-B in 60 adults with normal blood sugar or prediabetes. The goal is to see if it improves blood sugar control after meals over 90 days compared to a placebo. Participants will take the supplement daily and have their blood sugar leve…

This pilot study tests whether providing culturally appropriate food bundles and easy-to-read recipes can help adults with type 2 diabetes who face food insecurity. About 25 participants will receive food bundles and education, then complete surveys at 3 and 6 months. The goal is…

This study tests a program that gives fresh fruits and vegetables to Native American adults aged 55 and older who face food insecurity and have type 2 diabetes or are at risk. Participants receive vouchers to buy healthy food at local centers, along with nutrition education. The …

This study explores whether virtual reality (VR) experiences that raise heart rate can produce health benefits similar to real exercise. Researchers will test this in 48 sedentary adults with prediabetes, measuring changes in blood sugar and walking endurance. If successful, this…

This study tests whether adding SMS reminders with diet and exercise tips to a standard lifestyle program helps people with prediabetes lose more weight. About 300 adults in Reunion Island will either get the program alone or with 72 text messages over 6 months. The goal is to se…

This study tests whether mirabegron, a drug currently used for overactive bladder, can improve how the body handles sugar in people with prediabetes. Researchers will measure changes in glucose tolerance, body fat, and brown fat activity in 65 adults with prediabetes. The goal is…

This study tests whether a mobile app called PortionSize Ed can help 40 adults who recently had a stroke and have prediabetes or type 2 diabetes follow a Mediterranean diet. Participants use the app for 12 weeks, with some getting extra support from a dietitian. The goal is to se…

This small pilot study is testing whether eating Greek bottarga (grey mullet fish roe) every day can improve blood sugar, cholesterol, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 participants will compare the effects of bottarga against a dairy pro…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce food insecurity and improve insulin resistance. About 200 adults with HIV from a clinic…

This study looks at whether eating only during certain hours of the day (early or late) can help control blood sugar and improve heart health in people who are overweight and have normal blood sugar, prediabetes, or type 2 diabetes. Researchers will track blood sugar levels conti…

This study tests whether intermittent fasting can improve how the body releases insulin in people with prediabetes or early type 2 diabetes. About 200 adults with a BMI between 25 and 40 will follow a 4-week fasting plan or a control diet. The goal is to see if fasting can boost …

This study tests a 24-week program called Black Impact for Black men with below-ideal heart health. Participants will take part in weekly physical activity, health education, and work with a coach and trainer. The goal is to see if the program improves heart health and reduces st…

This study tests whether limiting food intake to a 9-hour window each day (time-restricted eating) can improve heart health in 100 adults with obesity and prediabetes. Participants will follow this eating pattern for 12 weeks without changing how much they eat. Researchers will m…

This study looks at whether eating pecans instead of snacks high in bad fats and sugar can improve blood sugar and heart health in people with prediabetes. About 147 adults aged 25-65 with prediabetes will either eat 1.5 ounces of pecans daily for 16 weeks or stick to their usual…

This study looks at how different types of keto diets affect heart health and inflammation in adults who are overweight or have prediabetes or type 2 diabetes. Participants will follow either a keto diet with healthy canola oil, a traditional keto diet high in saturated fat, or a…

This study tests whether providing medically tailored meals along with intensive lifestyle coaching can help adults with HIV and type 2 diabetes or prediabetes better manage their weight and blood sugar. About 200 participants will be randomly assigned to receive either the meals…

This study tests whether wearing a continuous glucose monitor (CGM) and watching AI-generated health videos can help people with prediabetes control their blood sugar. Fifty adults aged 35 and older with prediabetes will wear a CGM and receive smartphone feedback. The goal is to …

This study tests an online diabetes prevention program for UCLA undergraduates who are at risk for type 2 diabetes. The program includes short online lessons and aims to help participants lose weight and improve quality of life. Researchers will compare results between those who …

This study tests whether teaching basic carbohydrate counting can lower blood sugar levels in people with prediabetes. About 120 adults with prediabetes will either get standard lifestyle advice or extra training on counting carbs. Researchers will check HbA1c levels at 3 and 6 m…

This study is testing whether a special software that analyzes CT scans of the heart's arteries can better prevent heart attacks, strokes, and other cardiovascular events compared to usual care based on risk factors like cholesterol and blood pressure. The trial will enroll 7,500…

This pilot study tests whether a 12-week family-centered, non-calorie restricted whole foods diet can help prevent type 2 diabetes in adults with prediabetes. About 30 adult-child pairs will participate, with adults having prediabetes and children aged 6-18. The study measures fe…

This study looks at two different ways to help adults in rural communities prevent type 2 diabetes. Participants will either join group video sessions or follow a self-directed program. The goal is to see which method works better for weight loss and blood sugar control.

This study tests a family-oriented version of the Diabetes Prevention Program for Black families in Southwest Georgia. Parents with prediabetes and their children aged 8-15 will learn healthy eating and exercise habits together. The goal is to help parents lose weight and lower t…

This study looks at whether adding hands-on nutrition demonstrations to the standard Diabetes Prevention Program helps people at risk for prediabetes stay engaged. About 20 adults in Los Angeles will take part. The goal is to see if this approach is practical and acceptable, not …

This study is testing whether using smart wearable devices and a mobile health program can help overweight or obese people with early signs of heart problems (like slightly high blood pressure or blood sugar) improve their heart health. About 1,400 adults will be tracked for 6 to…

This study tests whether adding continuous glucose monitoring (CGM) to the standard Diabetes Prevention Program (DPP) helps adults with prediabetes stick with healthy habits and lower their risk of developing type 2 diabetes. About 214 adults with prediabetes will receive DPP coa…

This study tests whether combining a wearable smartwatch with personalized digital health coaching can help people at risk for or with early-stage chronic conditions (like high blood pressure, prediabetes, or obesity) become more active and improve their health. Researchers will …

This study looks at whether walking in a natural setting (like a park) is better for reducing stress, anxiety, and improving mood compared to walking in a built-up commercial area. 216 adults with prediabetes will walk 150 minutes per week for six weeks in each environment, with …

This study tests whether easy home-based strategies—like wearing blue-light blocking glasses, standing for 10 minutes each hour, and not eating after 8pm—can reduce the negative health effects of evening screen time. Researchers will track 30 adults with obesity or prediabetes wh…

This study looks at whether short-term beetroot juice (a source of nitrate) can improve blood vessel function, insulin sensitivity, and exercise ability in adults with prediabetes. Researchers will compare people who take metformin with those who do not. The goal is to find simpl…

This study tests whether a cold water extract from saffron tepals (the flower petals) can improve blood sugar and metabolism after a meal in 20 adults with obesity or prediabetes. Participants drink either the extract or plain water before eating white bread, then have blood test…

This study is tracking 1,250 people at higher risk for pancreas cancer, including those with new diabetes, chronic pancreatitis, or a family history. Researchers will collect blood samples and health data over time to find early warning signs. The goal is to develop a screening t…

This study looks at whether eating dinner earlier in the evening, in sync with your body's internal clock, helps burn more fat and control blood sugar. Researchers will compare early versus late dinners in healthy people and those with obesity and prediabetes. The goal is to unde…

This study looks at whether the artificial sweeteners aspartame and sucralose change how the body handles sugar in older adults with prediabetes. Researchers will give participants either one of the sweeteners or a placebo for several weeks and track blood sugar levels continuous…

This study looks at how lean pork loin compares to plant-based protein for muscle health and blood sugar control in adults with prediabetes. Twenty participants aged 40-65 will eat prepared meals for three days. Researchers will measure muscle protein building and daily glucose l…

This study looks at how genetic differences in Mexican-Americans with prediabetes affect their response to semaglutide (Ozempic), a GLP-1 drug. Researchers will measure changes in insulin production, blood sugar, and gene activity in 300 participants. The goal is to find genetic …

This study is looking for early warning signs of diabetes and its complications. Researchers will give a high-fat drink to 150 adults (ages 50-70) with prediabetes, type 2 diabetes, or healthy blood sugar. They will measure fats and inflammation in the blood before and after the …

This study follows 1,000 people who are having weight-loss (bariatric) surgery. Researchers will measure changes in weight, body fat, blood sugar, cholesterol, and other health markers before surgery and at several follow-up visits over two years. The goal is to better understand…

This study looks at how fat buildup in the pancreas contributes to type 2 diabetes and whether weight loss can reverse it. Researchers will follow 104 overweight adults, including those without diabetes, with prediabetes, and with short- or long-term diabetes. Participants will f…

This study looks at whether a community program rooted in Native Hawaiian values can improve the well-being of young people aged 12-25 who have health issues like asthma, obesity, or mental health concerns. About 100 youth from the Wai'anae area will take part in cultural activit…

This study looks at how the hormone glucagon affects insulin release and blood sugar levels in people with prediabetes. Researchers will give glucagon or sugar water to 60 volunteers and measure how their bodies respond. The goal is to better understand what causes high blood sug…

This study aims to find biological markers in the blood that show when insulin-making beta cells are damaged or dying. By studying 165 people with type 1 or type 2 diabetes, plus healthy volunteers, researchers hope to better understand how diabetes develops. The goal is to enabl…

This study is testing whether a smartphone-based program that provides high-fiber foods and continuous glucose monitors can help young adults (ages 18-39) with prediabetes improve their blood sugar control. The main goal is to see if people find the program easy to use and stick …

This study looks at how insulin and glucagon interact to manage blood sugar levels when people are not eating. Researchers will compare people with normal blood sugar to those with impaired fasting glucose (a sign of prediabetes). The goal is to better understand what goes wrong …

This study looks at how certain immune cells, called meta-inflammatory monocytes, along with body composition and diet, may lead to insulin resistance in teenagers. Researchers will collect blood samples and health information from 175 adolescents aged 14–18, including those with…

This study looks at how a person's natural sleep pattern (chronotype) affects their body's ability to handle sugar. Researchers will compare blood sugar and insulin responses in 70 overweight young adults (ages 18-23) who are either night owls or early birds. Participants will ta…

This study from Stanford University aims to understand why people's blood sugar levels respond differently to the same foods. Researchers will use continuous glucose monitors (CGMs) in 100 healthy adults, people with prediabetes, and those with type 2 diabetes to track blood suga…

This study looks at how an 8-week exercise program changes the bodies and cells of 40 overweight or obese adults with prediabetes. Researchers will measure weight, body fat, blood sugar, and other health markers. They will also use advanced techniques to study immune cells and fi…

This study looks at how a hormone called GLP-1, made in the pancreas, helps control blood sugar in people with prediabetes. Researchers will block GLP-1's action to see how it affects insulin and glucagon. The goal is to understand early changes that lead to type 2 diabetes. Abou…

This study tests whether data from a smart ring, smartwatch, and smartphone app can identify people with prediabetes (higher-than-normal blood sugar) compared to healthy individuals. About 200 adults aged 45 and older who are overweight will wear these devices for 4 weeks and log…