PREDIABETES

This pilot study tests whether a home exercise program plus a dietary supplement called nicotinamide riboside (similar to vitamin B3) can improve muscle health and insulin resistance in adult survivors of childhood cancer who have prediabetes. The study includes 20 participants a…

This pilot study explores how a 6-month low-carbohydrate diet affects blood sugar control, body composition, and gut-brain interactions in 40 obese adults with or without glucose intolerance or diabetes. Participants follow a low-carb eating plan, and researchers measure changes …

This study aimed to see if using an exercise phone app and a continuous glucose monitor could help teenagers with obesity, prediabetes, or type 2 diabetes lose weight and improve their health. Participants would have worn a glucose monitor and, if in the intervention group, used …

This study tests whether probiotics can control blood sugar as well as metformin in people with prediabetes. Thirty adults aged 31-60 with prediabetes will take either probiotics or metformin for 13 weeks. The goal is to see if probiotics offer a new treatment option to prevent t…

This study was designed to test whether metformin, a common diabetes drug, could improve blood vessel function in people with prediabetes. It planned to enroll adults aged 18-55 with prediabetes and compare metformin to a placebo over 12 weeks. However, the study was withdrawn be…

This study tests whether eating dried Saskatoon berries daily for 10 weeks can improve blood sugar and cholesterol levels in people with untreated prediabetes or new type 2 diabetes. Researchers will compare the effects of Saskatoon berries to a control dried fruit in 92 adults a…

This study tests whether empagliflozin, a drug used for type 2 diabetes, can improve blood sugar control in 60 overweight or obese adults with prediabetes. Participants take the drug or a placebo for 13 weeks. The goal is to see if the drug helps the body use sugar better and low…

This study aims to find the best combination of diet and exercise for weight loss in 30 adults with prediabetes and physical disabilities. Participants first try either a high or low carbohydrate diet for 4 weeks. Those who lose enough weight stay on their diet; others get extra …

This study tests whether portable ultrasound and blood glucose monitors can help doctors catch chronic conditions like diabetes, heart disease, and kidney disease earlier than usual. About 200 adults will use these devices or receive standard care for 6 months. The goal is to see…

This study uses artificial intelligence to examine the eyes of 100 adults with prediabetes or diabetes for early signs of diabetic retinopathy, a condition that can lead to blindness. Participants will have their retinas photographed with both stationary and mobile cameras, and a…

This study tests whether adding peer support and healthy food vouchers to a standard diabetes prevention program helps low-income adults with prediabetes stick with the program and lower their risk of developing diabetes. About 142 participants will be split into two groups: one …

This large, phase 4 trial is testing whether berberine, a natural compound, can prevent heart disease and diabetes in over 2,000 adults in China who are at high risk. Participants take berberine or a placebo twice a day, along with lifestyle advice. The study looks at blood sugar…

This study tests two simple tools—a decision aid and text messages—to help people with prediabetes choose lifestyle changes or metformin to prevent type 2 diabetes. About 960 adults from primary care clinics will take part. The goal is to see if these low-cost nudges lead to weig…

This pilot study tests whether pharmacist-led lifestyle education, wellness tools, and healthcare referrals can help hospitality workers in New Orleans prevent diabetes. About 300 adults with prediabetes or high risk will take part for one year. The goal is to see if this approac…

This study tests whether giving extra support—like phone calls and added resources—to Black adults who don't lose weight early in a community diabetes prevention program can help them succeed. About 400 participants from churches and community centers will take part. The goal is …

This study tests whether a combination of the diabetes drug metformin and a digital lifestyle program can safely prevent diabetes in adult survivors of childhood cancer who have prediabetes. About 96 participants will first try lifestyle changes alone for 12 weeks, then add metfo…

This study looks at whether adding CPAP (a machine that helps you breathe at night) to a healthy lifestyle program can lower the risk of diabetes in people with prediabetes and sleep apnea. About 174 overweight or obese adults with both conditions will be followed for 6 months. T…

This study tests a new tool for doctors that uses a patient questionnaire to see how ready someone is to make lifestyle changes. Based on the results, the tool suggests ways for doctors to talk about preventing diabetes and recommends helpful resources. About 100 adults with pred…

This study looks at whether adding supervised cycling and rowing to a Mediterranean diet improves blood sugar control better than diet alone in women with prediabetes. About 30 women will be split into three groups based on their blood sugar levels and will follow the program for…

This study tests whether eating 1.5 cups of fresh mango daily for 12 weeks can improve blood sugar, cholesterol, and inflammation in adults with prediabetes. Participants will eat mango for 12 weeks, then avoid it for another 12 weeks, so researchers can compare the effects. The …

This study looks at whether the amount of effort during resistance exercise (like lifting weights) changes blood sugar levels in people with prediabetes or type 2 diabetes. Fifteen participants will try a high-effort workout, a low-effort workout, and a no-exercise day. Researche…

This study looks at how the liver burns fat and makes sugar in people with NASH (a serious liver disease linked to obesity) who are planning to have weight-loss surgery. Researchers will use special scans to measure liver function before and after surgery in 30 adults. The goal i…

This study looked at over 16,000 people in Spain aged 45-70 who had risk factors like high blood pressure or smoking but no known heart disease. Researchers used ultrasound and urine tests to find hidden artery and kidney problems. The goal is to learn what factors lead to these …

This study is testing whether wearable devices like continuous glucose monitors and the Oura Ring can help predict how well the pancreas is working in people with prediabetes or type 2 diabetes. The goal is to develop remote tools that allow personalized treatment to preserve ins…

This study looks at whether routine blood sugar testing during dental checkups can help find hidden high blood sugar in people with advanced gum disease. About 300 adults with severe gum disease will get a simple finger-prick blood test during their dental visit. The goal is to s…

This study is testing a new type of clinic that screens people with prediabetes and type 2 diabetes for several hidden health problems at the same time, including fatty liver disease, sleep apnea, and heart failure. The goal is to see how common these undiagnosed conditions are a…

This study looks at whether two common artificial sweeteners, saccharin and acesulfame potassium, affect blood sugar control in older adults with prediabetes. Researchers will monitor 30 participants over 8 weeks using continuous glucose monitors and oral glucose tolerance tests.…

This pilot study looks at how environmental stress affects daily blood sugar changes in 30 Hispanic adults whose parent has type 2 diabetes. Researchers use continuous glucose monitors to track glucose and aim to design a future program to prevent diabetes. The study does not tes…

This study is a review of many smaller trials that looked at what happens when people replace animal protein (like meat, dairy, eggs) with plant protein (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weight,…

This study looks at how eating whole wheat bread changes gut bacteria and health markers in adults with prediabetes. Over two weeks, 65 participants will eat either whole wheat or white bread daily, then provide stool, urine, and blood samples. The goal is to understand if whole …

This study aimed to see if exercising in the morning versus the evening changes how the body handles sugar in adults with prediabetes. Participants would have completed short bouts of morning exercise, evening exercise, and no exercise, with their blood sugar and insulin levels m…

This study looked at whether adding pramlintide to semaglutide changes appetite and eating habits in obese adults with prediabetes. Researchers planned to give 40 participants weekly semaglutide for 24 weeks, then add either pramlintide or placebo for two more weeks. The goal was…

This study looks at whether older adults with prediabetes have slower thinking and less brain energy use compared to those with normal blood sugar. It also tests if a single dose of a ketone supplement can temporarily improve brain function. Twenty participants aged 60-75 will un…