Ancient herb berberine tested to stop heart disease and diabetes in its tracks
NCT ID NCT05749874
First seen Jan 04, 2026 · Last updated Jun 22, 2026 · Updated 23 times
Summary
This large, phase 4 trial is testing whether berberine, a natural compound, can prevent heart disease and diabetes in over 2,000 adults in China who are at high risk. Participants take berberine or a placebo twice a day, along with lifestyle advice. The study looks at blood sugar and other health markers after one year.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Fuwai Hospital, Chinese Academy of Medical Sciences, National Center for Cardiovascular Diseases
Beijing, China
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
berberine hydrochloride (a natural compound found in plants like goldenseal and barberry)
What this could lead to
If it works, this could point toward a simple, affordable supplement to help prevent heart disease and diabetes in people at high risk.
What could go wrong
This is a single large trial in China, so results may not apply to other populations. Berberine can cause digestive side effects, and the study is not yet complete.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.