PREDIABETES

This study compares two diabetes drugs, semaglutide and dapagliflozin, against the standard treatment metformin in 300 adults with pre-diabetes and coronary artery disease. The goal is to see if these drugs can slow or reverse the buildup of fatty plaque in the heart arteries ove…

This study looks at whether a pharmacist-led program using a continuous glucose monitor (CGM) can help people with prediabetes better control their blood sugar and make healthier choices. About 40 adults aged 18-70 with prediabetes will wear a CGM for 4 weeks and get guidance fro…

This study tests whether meal replacements can help low-income adults who are overweight or have prediabetes or type 2 diabetes lose weight and lower blood sugar. Twenty participants will follow an intensive nutrition program for several weeks. Researchers will measure weight los…

This study tests whether using a continuous glucose monitor (CGM) helps overweight teens with prediabetes follow lifestyle changes better. The goal is to improve insulin sensitivity and lower the risk of developing type 2 diabetes. About 15 teens aged 10 to 17 will use a CGM alon…

This study tests an investigational drug called MOTS-c in 120 adults with prediabetes and overweight or obesity. Participants receive either MOTS-c or a placebo for 12 weeks, along with lifestyle advice. The main goal is to see if MOTS-c improves how the body uses insulin, which …

This study is testing a special drink made with carob extract (called NUTIFOOD) to see if it helps people with prediabetes manage their blood sugar better. About 30 adults aged 18-65 with prediabetes will be randomly assigned to drink either the carob product or a placebo for a p…

This study tests whether mirabegron, a drug currently used for overactive bladder, can improve blood sugar control and activate calorie-burning brown fat in people with prediabetes. About 65 adults with prediabetes and a BMI between 27 and 45 will take the drug for several weeks.…

This study looks at whether limiting food intake to a 9-hour period each day can improve how the body uses insulin and manages blood sugar in people with obesity and prediabetes. Researchers will measure changes in insulin sensitivity, daily glucose control, and fat and muscle bi…

This study looks at whether artificial intelligence (AI) can give personalized tooth-brushing advice to people with prediabetes, just as well as a dentist can. The goal is to see if better oral hygiene can reduce gum disease and also help control blood sugar levels. About 148 adu…

This study tests whether a supplement called dihydroberberine (DHB) can help adults with prediabetes improve blood sugar control and reduce appetite. About 54 participants will take either DHB or a placebo daily for 6 weeks. Researchers will measure blood sugar, insulin, and horm…

This study tests a 24-week program called Black Impact to improve heart health and reduce stress in Black men. About 340 Black men with below-ideal heart health will either join the program right away or be placed on a waitlist. The program includes weekly exercise, health educat…

This study looks at whether eating baked potatoes with the skin, along with a Mediterranean-style diet, can improve blood sugar, cholesterol, and blood pressure in adults with pre-diabetes. About 60 people aged 45-80 will either follow the Mediterranean diet alone or add baked po…

This study tests whether simple home-based strategies and wearable devices can help reduce the negative health impact of evening screen time. Researchers will enroll 30 adults who spend at least 3 hours per day on recreational screens and have risk factors for heart disease, diab…

This study looks at how food insecurity affects heart and metabolic health in people with HIV. Researchers will test a program that combines peer support and a mobile health app to help reduce these health risks. About 200 adults with HIV who are patients at a North Carolina clin…

This study looks at whether a 4-week intermittent fasting plan can improve how the body releases insulin in people with prediabetes or early type 2 diabetes. Researchers will compare fasting to a regular diet in 200 adults with a BMI between 25 and 40. The goal is to see if this …

This study gives 400 adults with diabetes or prediabetes free fresh food boxes and nutrition education twice a month for six months. Researchers will check if this helps improve blood sugar levels and reduce food insecurity. The goal is to see if better access to healthy food can…

This study looks at whether eating peanuts every day can improve blood sugar, blood pressure, thinking skills, and gut health in adults with prediabetes. Researchers will enroll 72 racially diverse participants aged 20-59. Over 14 months, each person will follow both a peanut-eat…

This study tests whether providing medically tailored meals along with intensive lifestyle coaching helps adults with HIV and type 2 diabetes (or high risk for it) lose weight and control blood sugar better than meals alone. About 200 participants will be followed for 18 months. …

This study tests whether adding SMS reminders with diet and exercise tips to a standard lifestyle program helps people with prediabetes lose more weight. About 300 adults in Reunion Island will be split into two groups: one gets the program plus 72 text messages over 6 months, th…

This study tests if a mobile app called PortionSize Ed can help 40 adults who recently had a stroke and have prediabetes or type 2 diabetes follow a Mediterranean diet. Participants will either use the full app with dietitian support or a basic version. The goal is to see if the …

This study looks at whether connecting youth (ages 12-25) with community programs rooted in Native Hawaiian culture can improve their mental and physical health. Participants will take part in activities that strengthen their connection to the land and culture, and complete surve…

This small pilot study is testing whether eating bottarga (a type of fish roe) every day for 8 weeks can improve cholesterol, blood sugar, and inflammation in adults with prediabetes, diabetes, or obesity. About 20 adults from Massachusetts will take part. The goal is to see if t…

This study tests whether a keto diet using canola oil (healthy fats) is better for heart health than a traditional keto diet high in saturated fat or a low-fat diet. Researchers will measure cholesterol, blood sugar, and inflammation in 175 adults with prediabetes or type 2 diabe…

This study tests whether a mobile health program that provides high-fiber foods, education, and continuous glucose monitors can help young adults (ages 18-39) with prediabetes improve their blood sugar control. The study will enroll 80 participants in the Tulsa area and measure h…

This study looks at whether using portable air cleaners at home can improve blood sugar control and reduce inflammation in adults with prediabetes. Researchers will measure changes in glucose levels and inflammatory markers over 4 weeks. The goal is to see if reducing air polluti…

This study compares two approaches to preventing type 2 diabetes in 40 adults with prediabetes. One group follows the standard Diabetes Prevention Program, while the other adds sleep health advice and time-restricted eating. The goal is to see which method leads to more weight lo…

This study tests whether a 12-week family-centered whole foods diet can help prevent type 2 diabetes in adults with prediabetes and improve eating habits for both adults and children. About 30 adult-child pairs will participate, with some following the whole foods diet and others…

This study tests whether wearing a continuous glucose monitor and watching AI-generated health education videos can help people with prediabetes keep their blood sugar in check. About 50 adults aged 35 and older with prediabetes will use the device and videos for several weeks. T…

This study compares two ways to prevent heart problems in people with type 2 diabetes, prediabetes, or metabolic syndrome who are at higher risk but have no known heart disease. One group gets care based on a detailed heart scan staging system, while the other gets standard care …

This study tests an online program to help at-risk UCLA students prevent type 2 diabetes. About 80 students with prediabetes or high risk will take part. The program focuses on weight loss and healthy habits, and researchers will see if it works and is easy to use.

This study is testing whether using a smartwatch along with personalized digital health coaching can help people at risk for or with early-stage chronic conditions (like high blood pressure, prediabetes, or obesity) become more active and improve their health. About 1,700 adults …

This study tests whether adding a continuous glucose monitor (CGM) to the standard Diabetes Prevention Program (DPP) helps adults with prediabetes stay on track with lifestyle changes. About 214 adults with prediabetes will use a CGM and attend coaching sessions to see if their b…

This study tests whether using a smart wearable device (like a fitness tracker) along with health coaching can improve heart health in overweight or obese adults who have early warning signs like slightly high blood pressure, blood sugar, or cholesterol. About 1,400 participants …

This study tests whether adding hands-on nutrition demonstrations helps people at risk for prediabetes stay in the Diabetes Prevention Program. About 20 adults who are eligible for the program will take part. The goal is to see if this approach improves participation and health h…

This study tests a program called Regulation of Cues (ROC) adapted for Latinas with prediabetes and obesity. The goal is to see if it helps them manage food cravings, lose weight, and prevent type 2 diabetes. Thirty women aged 18-55 will attend 14 sessions and rate how helpful th…

This study compares two ways to deliver a diabetes prevention program to 160 adults in rural communities who have prediabetes. One group will join video sessions, the other will follow a self-directed plan. The goal is to see which approach works better for weight loss and blood …

This study tests a supplement called Nextida GC-B to see if it helps control blood sugar after meals in adults with normal blood sugar or prediabetes. Sixty participants will take either the supplement or a placebo daily for 90 days. Researchers will measure changes in blood suga…

This early-phase study tests whether a cold water extract from saffron flower petals (Crocus sativus tepals) can improve blood sugar and metabolism after a meal. Twenty adults with obesity or prediabetes will drink either the extract or plain water before eating white bread, then…

This study tests whether limiting eating to specific hours of the day (early or late) helps control blood sugar and improve heart health in people who are overweight and have normal blood sugar, prediabetes, or type 2 diabetes. Researchers will monitor 30 participants' glucose le…

This study looks at how an 8-week exercise program changes the body and cells of 40 overweight or obese adults with prediabetes. Researchers will measure weight, body fat, blood sugar, and other health markers, and use advanced cell analysis to find clues about how exercise impro…

This study is following 1,250 people who are at higher risk for pancreas cancer, such as those with new diabetes, pancreas cysts, or a family history. Researchers will collect blood samples and health information over time to find early warning signs of the disease. The goal is t…

This study looks at how genes influence the body's response to a natural hormone called GLP-1 in Mexican-Americans with prediabetes. Researchers will analyze DNA and gene activity to understand why some people respond better than others. The goal is to find new ways to personaliz…

This study from Stanford University looks at why different people have different blood sugar responses to the same foods. Researchers will use continuous glucose monitors (CGMs) in 100 healthy adults, people with prediabetes, and those with type 2 diabetes to track blood sugar af…

This study looks at how the hormone glucagon influences insulin release and blood sugar levels in people with prediabetes. Researchers will give glucagon or glucose to 60 participants and measure changes in insulin production and sugar processing. The goal is to better understand…

This study looks at how insulin and glucagon interact to control blood sugar levels when people haven't eaten. Researchers will compare people with normal blood sugar and those with prediabetes to better understand what goes wrong. The goal is to learn more about fasting glucose …

This study is following 1,000 people who are having bariatric (weight-loss) surgery to see how their weight, body fat, and blood sugar levels change over two years. Participants will have tests before surgery and at several follow-up visits. The goal is to better understand the h…

This study looks at whether eating dinner earlier in the day can improve how the body burns fat and handles blood sugar. Researchers will compare early versus late dinner in 32 adults, including healthy-weight individuals and those with obesity and prediabetes. The goal is to und…

This study looks at whether walking in nature (parks, preserves) or walking in built-up areas (shopping centers, streets) is better for reducing stress and anxiety in adults with prediabetes. About 216 people aged 25-64 will walk 150 minutes each week for six weeks in each type o…

This study looks at how a hormone called GLP-1, made in the pancreas, helps control blood sugar in people with prediabetes. Researchers will block the hormone's action to see how it affects insulin and glucagon release. The goal is to learn why some people develop type 2 diabetes…