PREDIABETES

This study tests if probiotics can help control blood sugar in people with prediabetes, comparing them to the standard drug metformin. About 30 adults aged 31-60 with prediabetes and overweight will take either probiotics or metformin for 13 weeks. The goal is to see if probiotic…

This study was designed to test whether metformin, a common diabetes drug, could improve blood vessel function in people with prediabetes. It planned to enroll adults aged 18-55 with prediabetes and compare metformin to a placebo over 12 weeks. However, the study was withdrawn be…

This study aims to find the most effective weight loss strategy for adults with prediabetes and physical disabilities. Over 16 weeks, participants will try different diet plans, and those who don't lose enough weight will get extra exercise or time-restricted eating. The goal is …

This study tests whether eating dried Saskatoon berries every day can improve blood sugar and cholesterol levels in people with untreated prediabetes or new type 2 diabetes. About 92 adults will eat either Saskatoon berries or a control dried fruit for 10 weeks. Researchers will …

This study tests whether empagliflozin, a drug used for type 2 diabetes, can improve blood sugar control in 60 overweight or obese adults with prediabetes. Participants take the drug or a placebo for 13 weeks. The goal is to see if the drug helps the body use sugar better and low…

This study tests if portable devices like handheld ultrasound and blood glucose monitors can find chronic diseases such as diabetes, heart disease, and kidney disease earlier than standard care. About 200 adults aged 18 to 75 will use these devices or receive usual care for 6 mon…

This study looks at whether routine blood sugar testing during dental exams can find hidden high blood sugar in people with advanced gum disease. About 300 adults with severe periodontitis will get a finger-prick blood test. The goal is to see how common undiagnosed high blood su…

This study tests whether pharmacists can help hospitality workers in New Orleans learn how to prevent diabetes. About 300 adults who work in hotels, restaurants, or similar jobs will attend education sessions and receive wellness tools like fitness trackers. The goal is to see if…

This study looks at whether adding CPAP therapy (a machine that helps you breathe during sleep) to standard lifestyle changes can lower the risk of developing diabetes in people who have prediabetes and are overweight. About 174 participants will be followed for 6 months to see i…

This study tests whether a combination of the diabetes drug metformin and a digital lifestyle program can safely prevent diabetes in adult survivors of childhood cancer who have prediabetes. About 96 participants will first try lifestyle changes alone for 12 weeks, then add metfo…

This study tests whether berberine, a natural compound, can prevent heart disease and diabetes in over 2000 adults with high cardiometabolic risk (prediabetes, obesity, high blood pressure, or existing heart disease). Participants take berberine or a placebo for one year, and res…

This study looks at whether adding a support partner and vouchers for healthy food can help people with prediabetes stick to a diabetes prevention program. About 142 low-income adults will either join the standard program or get extra help from a peer and food vouchers. The goal …

This study tests whether simple reminders and encouragement (behavioral nudges) can help adults with prediabetes take proven steps to prevent diabetes, such as joining a lifestyle program or taking metformin. About 960 English- or Spanish-speaking adults aged 18-80 with prediabet…

This study looks at whether adding supervised cycling and rowing to a Mediterranean diet helps women with prediabetes control their blood sugar better than diet alone. About 30 women will be split into three groups based on their current blood sugar levels. They will follow the d…

This study tests a new tool that helps doctors have better conversations with patients who have prediabetes. The tool uses a questionnaire to understand how ready a patient is to make healthy changes, then suggests resources like health coaches or diabetes prevention programs. Ab…

This study looks at whether the amount of effort during weightlifting changes blood sugar levels in people with prediabetes or type 2 diabetes. Fifteen adults will try a high-effort workout, a low-effort workout, and a rest day to compare blood sugar and how they feel. The goal i…

This study aimed to see if exercising in the morning versus the evening changes how the body handles sugar in adults with prediabetes. Participants would have completed short exercise sessions at different times, with their blood sugar and sleep tracked. However, the study was wi…

This study looks at whether older adults with prediabetes have slower thinking and less brain energy use compared to those with normal blood sugar. Researchers will test if a single dose of a ketone supplement can temporarily improve brain function and energy use during thinking …

This study looked at over 16,600 people in Spain who had risk factors like high blood pressure or smoking, but no known heart disease. Researchers used ultrasound and urine tests to find hidden signs of artery and kidney disease. The goal is to learn what factors predict these hi…

This study was designed to see if adding pramlintide to semaglutide helps control appetite and eating habits in obese people with prediabetes. Researchers planned to give 40 participants weekly semaglutide injections for 24 weeks, then add either pramlintide or a placebo for two …

This study looks at whether a program of exercise and a dietary supplement called nicotinamide riboside (similar to vitamin B3) can improve muscle health and insulin resistance in adult survivors of childhood cancer who have prediabetes. About 20 participants will follow a 6-week…

This study is a review of many smaller trials that looked at what happens when people replace animal proteins (like meat, dairy, eggs) with plant proteins (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weigh…

This study uses artificial intelligence to examine the eyes of 100 adults with prediabetes or diabetes for early signs of diabetic retinopathy, a condition that can lead to vision loss. Participants undergo retinal imaging with both stationary and mobile cameras, and an AI algori…

This study looks at how eating whole wheat bread changes gut bacteria and health markers in adults with prediabetes. Over two weeks, 65 participants will eat either whole wheat or white bread daily, then provide stool, urine, and blood samples. The goal is to understand how whole…