Ear zaps could tame blood sugar and boost mood in obesity
NCT ID NCT07334951
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether a device that gently stimulates the vagus nerve through the ear can improve how the body handles sugar and affect mood in people with obesity and prediabetes. Seventy participants will use the device for 45 minutes, three times a week for three months. The goal is to see if this simple, non-invasive approach can help control blood sugar and insulin resistance.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- auricular vagus nerve stimulation device
- What this could lead to
- If it works, this could offer a non-drug way to help control blood sugar and improve mood in people with obesity and prediabetes.
- What could go wrong
- This is a small, early-stage study with only 70 participants, and it's not yet known if the device will produce meaningful or lasting benefits. The results may not apply to everyone with obesity or diabetes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 70 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Jan 2026
- Expected to finish
-
Aug 2026
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
40 to 50 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria:40\_50years Both sexes , BMI more than or equal 30 kg/m2 FBG less than 7 mmol/l 2hpp between 7.8 and 11.1mmol/l at the time of enrollment . HOMA-IR \>2.9 All are sedentary level activities. Exclusion Criteria:Diagnostic type 1and 2 DM Cardiovascular disease, stroke, uncontrolled hypertension Use psychoactive drugs, antiepliptic drugs, antidepressants. Present of metal implants, pace maker or cochlear implants. History of epilepsy or seizours . Pregnancy or breast feeding. Dermatologist condition near stimulating site. Major psychiatric disorders. \-
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Tanta general hospital
Tanta, Algarbia, 31511, Egypt
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