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Can exercise and a B3 supplement help cancer survivors fight prediabetes?

NCT ID NCT05023993

Disease control Sponsor: City of Hope Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study looks at whether a home exercise program plus a dietary supplement called nicotinamide riboside (similar to vitamin B3) can improve muscle health and insulin resistance in adult survivors of childhood cancer who have prediabetes. The study will enroll 20 people and mainly checks if the program is practical and doable. If successful, it may lead to larger studies on managing metabolic health in this group.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nicotinamide riboside (a dietary supplement similar to vitamin B3) and a home exercise program
What this could lead to
If this small pilot works, it could point toward a way to help childhood cancer survivors manage prediabetes and improve muscle health.
What could go wrong
This is a very early, small study (20 people) testing feasibility, not effectiveness. The supplement and exercise may not improve health outcomes, and results may not apply to all survivors.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

20 people

The number who actually took part.

Started

Jun 2022

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * History of childhood cancer * History of prediabetes (HbA1c 5.7-6.4%) * In remission at time of enrollment * Time between completion of cancer-directed therapy and study entry: \>= 6 months * At least 18 years of age at time of enrollment * Able to access online exercise program at home * Ability to tolerate the prescribed resistance exercise program * English-speaking * Able to understand and sign the study specific informed consent form (ICF) Exclusion Criteria: * Taking a nicotinamide adenine dinucleotide (NAD)+ precursor in the two weeks prior to enrollment * Currently taking medication for hyperglycemia or diabetes * Females who are pregnant or planning to become pregnant * Currently recovering from an injury * Contraindication to magnetic resonance imaging (MRI) * Pacemaker

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Conditions

The condition(s) this trial relates to.

cancer childhood malignant neoplasm hematopoietic and lymphoid cell neoplasm hematopoietic and lymphoid system neoplasm prediabetes syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hematopoietic and lymphoid cell neoplasm Malignant solid neoplasm Prediabetes

Contacts and locations

Locations

  • City of Hope Medical Center

    Duarte, California, 91010, United States

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