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Whole wheat vs. white bread: gut health showdown in prediabetes

NCT ID NCT05318183

Knowledge-focused Sponsor: Ohio State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how eating whole wheat bread affects gut bacteria and health in adults with prediabetes. 65 participants will eat either whole wheat or white bread for two weeks, then provide stool, urine, and blood samples. The goal is to see if whole wheat can improve blood sugar and reduce inflammation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Whole wheat bread
What this could lead to
If it works, this could point toward dietary recommendations for managing prediabetes through gut health.
What could go wrong
This is a small, early-stage study with only 65 people over 2 weeks. Results may not apply to everyone or lead to clear health changes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

65 people

The number who actually took part.

Started

Jan 2022

Expected to finish

May 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Fasting blood glucose between 100-125 mg/dL * BMI of 30-35 kg/m2 Exclusion Criteria: * History of liver disease, cardiovascular disease, overt diabetes, or cancer * Prescribed medications for hyperglycemia or dyslipidemia * Use of dietary supplements, prebiotics, or probiotics * Usage of antibiotics or anti-fungals within 3 months prior to enrollment * Smoker * Alcohol consumption greater than 2 drinks per day * Aerobic exercise greater than 5 hours per week * Pregnancy or fertility treatments * History of chronically active inflammatory or neoplastic disease in 3 years prior to enrollment * History of chronic gastrointestinal disorder including diarrhea, inflammatory bowel disease, celiac disease; coagulation disorders, chronic immunosuppressive medication usage * History of myocardial infarction or cerebrovascular accident within 6 months prior to participation

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Conditions

The condition(s) this trial relates to.

Dysbiosis Endotoxemia Inflammation inflammatory disease prediabetes syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dysbiosis Endotoxemia Inflammation Prediabetes

Contacts and locations

Locations

  • The Ohio State University

    Columbus, Ohio, 43210, United States

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