Ohio State University

This study looks at whether allowing slightly higher blood sugar levels (70-140 mg/dL) during labor is as safe as the current strict approach (70-110 mg/dL) for pregnant women with type 1 diabetes. About 44 women will be randomly assigned to one of the two groups. The main goal i…

This study looks at whether a mobile app that gives patients with sickle cell disease easy-to-use guidelines can help them have fewer emergency room visits and hospital stays. About 287 adults with sickle cell disease will use the app along with a booklet, or just the booklet alo…

This study tests whether a 7-day course of three antibiotics (ceftriaxone, clarithromycin, metronidazole) can prolong pregnancy and improve outcomes for pregnant individuals whose water breaks early (before 34 weeks). About 56 participants will be randomly assigned to the new com…

This study tests whether a special monitoring system (electrocochleography) used during cochlear implant surgery can help save some natural hearing. About 40 adults with severe hearing loss in both ears will be randomly assigned to receive the monitoring or standard care. The goa…

This study compares two treatments for gestational diabetes (high blood sugar during pregnancy): metformin pills versus insulin shots. About 1,572 pregnant women will be randomly assigned to one treatment to see if metformin works as well as insulin in preventing problems for the…

This study tests a wearable arm sleeve that uses electrical stimulation to help people with chronic tetraplegia (paralysis from a neck injury) regain the ability to grasp objects. Twelve adults will use the sleeve during 12 weeks of hand therapy. The goal is to see if the device …

This study tests whether taking atorvastatin for 3 months after breastfeeding can reduce long-term heart disease risk in women who had high blood pressure disorders during pregnancy. 76 participants will receive either the drug or a placebo. The goal is to see if this short treat…

This study aims to reduce suicidal thoughts and behaviors in people with PTSD. Researchers are testing whether adding a crisis response plan to standard prolonged exposure therapy works better than therapy alone. About 100 adults with PTSD and suicidal thoughts will participate, …

This study tests a 24-week program called Black Impact to improve heart health and reduce stress in Black men. About 340 Black men with below-ideal heart health will either join the program right away or be placed on a waitlist. The program includes weekly exercise, health educat…

This study tests a new program called MOMI PODS, designed to help new mothers with heart or mental health conditions after pregnancy. About 384 mother-baby pairs will be split into two groups: one gets the new program, the other gets standard care. The goal is to see if the progr…

This study looks at whether a well-formulated ketogenic diet can slow the progression of polycystic kidney disease (ADPKD) in 20 adults who are at high risk for kidney failure. Participants will follow the diet for one year and have regular MRIs, blood tests, and urine tests to t…

This study tests whether a special MRI technique called DCE-MRI can help doctors choose the best chemotherapy for people with borderline resectable pancreatic cancer. The goal is to shrink the tumor enough so it can be removed by surgery. About 50 adults with newly diagnosed, unt…

This study tests whether a 24-week food and fitness program helps 200 post-menopausal women with type 2 diabetes and heart-kidney problems stick to their new GLP-1 medication. The program includes exercise sessions, nutrition counseling, and home food deliveries. Researchers will…

This study tests a 10-week swim program called AquOTic for children with autism ages 5 to 9. The program uses one-on-one coaching in small groups to teach water safety and swimming skills. Researchers want to see if it works and whether trained students or community instructors a…

This study tests whether suvorexant, a drug used for insomnia, can help people with alcohol use disorder drink less and handle stress better. About 250 adults who want to cut back on alcohol will take the drug or a placebo nightly for 8 weeks. Researchers will track drinking, cra…

This study looks at whether adding occupational therapy and dietitian services to home-delivered meals can reduce fall risk in older adults who have trouble leaving home. About 750 people aged 60 and older will receive either meals alone, meals with dietitian support, meals with …

This study is working to create a better way to diagnose pneumonia in older adults (65+) who come to the emergency room. Researchers will observe 250 patients with suspected pneumonia and test if new biomarkers can improve accuracy. The goal is to help doctors quickly tell if it'…

This study tests if Irrisept, an antiseptic rinse, can prevent urinary tract infections (UTIs) when a urinary catheter is removed. About 300 adults will get either Irrisept or a saltwater rinse before removal. The goal is to see if Irrisept reduces infections and the need for ant…

This large study tests whether taking 162 mg of aspirin daily is better than the usual 81 mg dose at preventing high blood pressure disorders like preeclampsia during pregnancy. Over 10,000 pregnant individuals at higher risk will be followed to see which dose works best and what…

This study tests whether offering counseling, advocacy, and support services at a drop-in center can prevent opioid use disorder in homeless youth aged 14 to 24. About 300 participants will be split into groups receiving different combinations of services, and researchers will tr…

This study tests whether a nightly drop of a low-dose medicine (atropine) can delay the start of nearsightedness in children ages 6 to 11 who are not yet nearsighted. About 664 children will receive either the active drop or a placebo for two years. The goal is to see if the trea…

This study looks at whether taking antibiotics before a procedure called urethral bulking (using Bulkamid gel) for stress urinary incontinence can lower the chance of getting a urinary tract infection (UTI) right after. About 138 adults will be randomly assigned to get either ant…

This study explores whether aquatic therapy in a warm pool can help children ages 3-9 with cerebral palsy or similar movement problems. Over ten weeks, kids attend pool sessions twice a week to improve swim safety, arm function, and daily self-care. Researchers will measure chang…

This 12-week study at Ohio State University tests whether a keto diet or a mixed diet with ketone supplements can help women with PCOS have more regular periods and improve hormone balance. About 40 women aged 18-40 with PCOS will be randomly assigned to one of two groups. The go…

This study tests whether a ketone ester supplement can improve heart function and exercise ability in people with type 2 diabetes. About 30 adults with diabetes will take either the supplement or a placebo and undergo heart scans and treadmill tests. The goal is to see if this si…

This study looks at how comfortable and clear a weekly replacement contact lens feels for adults with astigmatism who have never worn contacts. Sixty participants will wear the lenses for about three weeks and complete surveys about their experience. The goal is to see if these l…

This study is testing a new online exercise program designed specifically for people with chronic brain injury. The program, called SPIRIT Club CBI Pathway, offers workouts that are accessible and supportive. Researchers will enroll 60 adults who are at least 9 months past their …

This study tests whether a low-sugar diet and mild electrical stimulation to the legs can prevent blood pressure from dropping too low after meals in people with chronic spinal cord injury. Researchers will measure blood pressure changes in the lab and at home over several days. …

This study tests whether listening to 15 minutes of frequency-filtered music before daily therapy sessions can make PTSD treatment more effective. About 100 adults with PTSD will receive 10 sessions of cognitive processing therapy, plus either filtered or unfiltered music. Resear…

This study is testing whether people with recurrent acute or chronic pancreatitis can safely drink a soy tomato juice every day. Researchers will check if the juice reduces inflammation and improves symptoms and quality of life. About 35 adults will participate, and everyone will…

This study tests whether a type of talk therapy, delivered via video call, can reduce suicidal thoughts and attempts in adults with physical disabilities (vision, hearing, or mobility issues). Researchers will enroll 60 people who have had recent suicidal thoughts or a recent sui…

This study looks at whether dry needling can reduce pain and improve leg strength and function in people with long-term knee pain (at least 3 months). Researchers will use thin needles to relax tight muscles. The study involves 120 adults aged 18 to 40 who have been referred for …

This study tests whether taking pancrelipase (CREON) for 6 months can improve symptoms of exocrine pancreatic insufficiency (EPI) — a condition where the pancreas doesn't make enough enzymes to digest food — after an attack of acute pancreatitis. About 60 adults with confirmed EP…

This study looks at how people over 40 with presbyopia (age-related blurry near vision) feel about wearing multifocal contact lenses compared to regular contact lenses plus reading glasses. About 30 participants will try both options and say which they prefer. The goal is to see …

This study looks at how comfortable daily disposable contact lenses are for people with astigmatism who wear them for long hours. About 40 current contact lens users will try the lenses and rate their comfort. The goal is to see if these lenses can make long wear days more pleasa…

This study tests a precise radiation treatment aimed at nerves in the back to reduce muscle tightness (spasticity) caused by stroke, spinal cord injury, or cerebral palsy. About 22 people will be randomly assigned to receive either the real treatment or a sham (fake) procedure. R…

This study tests if adding a short therapy for fear of uncertainty to standard firearm safety counseling helps military members store guns more safely. About 100 active or recently discharged service members who own an unlocked, loaded firearm will take part. They will attend two…

This study tests whether eating 12 grams of a special oil (high in linoleic acid) every day can help older adults with muscle loss (sarcopenia) improve their strength, muscle size, and mobility. Researchers will compare the oil to a placebo over time. The goal is to find a simple…

This study tests whether adding a brief crisis coping strategy (Crisis Response Planning) to a standard PTSD talk therapy (Cognitive Processing Therapy) can lower suicidal thoughts and behaviors in veterans. About 190 active-duty service members and veterans with PTSD and recent …

This study tests a telehealth program where parents coach their child (ages 1-6) with severe motor delays to use an adaptive stander for 30 minutes, three times a week. One session each week is guided by a physical therapist via video call. Researchers will measure changes in the…

This study tests whether adding Cognitive Therapy for Suicide Prevention (CTSP) to standard services can reduce suicidal thoughts in homeless youth aged 15-24 who use alcohol or drugs. About 300 participants will be split into two groups: one gets CTSP plus usual care, the other …

This study tests a simple change in how a breathing tube is placed during surgery. By rotating the tube 180 degrees before insertion, doctors hope to lower the chance of a sore throat afterward. About 357 adults having surgery with a breathing tube will take part. The goal is to …

This study looks at whether using lower pressure gas during laparoscopic large bowel surgery can prevent temporary bowel paralysis (postoperative ileus) and help patients recover and leave the hospital sooner. About 125 adults having laparoscopic right colon or sigmoid colon surg…

This study tests whether a 6-week group program can reduce loneliness and improve mental health in adults living in agricultural areas. Researchers will enroll 65 people who feel lonely or disconnected. Participants will attend weekly sessions and report changes in loneliness, an…

This study looks at whether a continuous glucose monitor (CGM) — a small sensor worn under the skin — can help screen women for diabetes risk after having gestational diabetes. About 20 women will wear the CGM for a short time after giving birth and answer surveys about their exp…

This study follows 400 rural families in Ohio START to see if nearby treatment services and peer mentors help parents recover from substance use and improve child well-being. Participants answer surveys and share their daily locations and social connections over a year. The goal …

This study looks at how different emotion regulation strategies—like distraction, seeking support, or thinking about reasons for living—affect suicidal thoughts in U.S. military personnel. Researchers will use smartphone surveys to track participants' strategies and feelings in r…

This study is testing a small, portable device called the P4 that sits inside an MRI scanner to make the images more consistent and accurate. The goal is to better measure how well pancreatic cancer treatments are working by tracking blood flow changes in the tumor. The study inc…

This study aims to create better methods for measuring arm and hand movements in infants, including those with perinatal stroke or cerebral palsy. Researchers will analyze video recordings and developmental tests from 80 children (8-36 months old) to build a new assessment tool c…

This study looks at whether a new, specially designed microcatheter works better than standard tools for treating a type of brain bleed called chronic subdural hematoma. About 100 adults with this condition will take part. Researchers will compare procedure time, success rates, a…

This study looks at whether using educational media (like TV shows or apps) together with a caregiver can help children ages 3 to 5 learn early reading skills. About 450 children and their caregivers will be split into three groups: one using media, one reading storybooks, and on…

This study looks at how removing a type of brain tumor called a meningioma affects a person's thinking and memory over a year. Researchers will test 50 adults before and after surgery to see if their cognitive skills change. The goal is to better understand the long-term effects …

This study is testing a new rehabilitation program for people with spinal cord injury (SCI) that combines walking downhill on a treadmill with mild electrical muscle stimulation. Researchers will check blood and spinal fluid for biomarkers to decide whether to start the program r…

This study looks at whether taking vitamin C every day can improve gut health and reduce inflammation in adults with obesity. Participants will take vitamin C or a placebo for two weeks, then switch. Researchers will collect blood, urine, and stool samples to measure gut permeabi…

This study watches 30 dental patients who need bone grafting before getting implants. If the gum doesn't fully cover the graft, surgeons may place a collagen patch. Researchers compare healing and success with or without the patch. The study does not change the care patients rece…

This study watches how gum grafts heal in 15 people after standard gum recession surgery. Researchers use a digital scanner, a blood flow device, and saliva tests to track swelling, new blood vessel growth, and healing chemicals. Participants also fill out pain questionnaires. Th…

This study looks at whether people with a history of impulsive aggression react differently to inflammation than those without. Researchers will give a low dose of endotoxin (which causes temporary inflammation) or a placebo to 112 adults, then measure anger, aggression, and brai…

This study looks at pregnant people at risk for preeclampsia who are taking aspirin as part of their care. Researchers will collect blood samples up to four times during pregnancy to measure proteins from the placenta. The goal is to understand how aspirin affects these proteins …

This study aims to create a treatment prognosis calculator for 1,200 active-duty military members with suicidal thoughts. The goal is to predict who will improve with standard care and who might benefit more from a specialized therapy called Brief Cognitive Behavioral Therapy (BC…

This study compares a new bone marrow collection system to the standard one in 6 adults having hip surgery for bone loss. Participants give marrow from both hips, but only the standard-system sample is used during surgery. The new-system sample and a blood sample are sent to a la…

This study looks at two thinking and memory tests—the Coding Test and the SAGE—to see if they can help screen and track Huntington's disease. Researchers will compare these tests with standard ones in 76 adults aged 30-65 who have a genetic diagnosis of Huntington's. The goal is …

This study tests a caregiver-led reading program called Sit Together and Read (STAR) in 320 children aged 4 to 5 with developmental language disorder. Researchers want to see if STAR improves literacy skills right after the program and up to two years later. They also test whethe…

This observational study will compare the health history and movement patterns of 10,500 people with and without low back or neck pain. Participants wear a motion monitor and answer questionnaires in one 40-70 minute session, with follow-ups over 5 years. The goal is to better un…

This study watches and analyzes video recordings of occupational therapy sessions for adults recovering from stroke or spinal cord injury. Researchers want to identify exactly what therapists do to help improve arm and hand function. The goal is to create a toolkit that makes reh…

This study tests whether screening for diabetes right after giving birth (before leaving the hospital) is more effective than the usual 4-12 week wait for new mothers who had gestational diabetes. It also surveys participants about their views on heart health programs and barrier…

This study looks at how babies move and make sounds to find early clues for conditions like cerebral palsy and autism. Researchers will ask parents to upload short videos of their child at different ages. The goal is to learn which patterns are normal and which might signal a nee…

This study looks at whether a series of balance exercises can help healthy older adults better sense motion and improve their balance. Thirty participants will practice tilting and moving on a special platform over about 45 days. The goal is to understand how the inner ear's sens…

This study looks at how different types of dietary fats affect thinking and memory in adults who have mild memory complaints. Over 88 participants will eat a special snack each day for one week. Researchers will measure brain function and gut health to see if certain fats can hel…

This study looks at how well the bones in the neck fuse together after a type of spine surgery called posterior cervical fusion, where small spacers are placed between the joints. Researchers will follow 45 adults for up to 2 years after surgery, using X-rays and CT scans to chec…

This study collects skin samples from 175 people with hidradenitis suppurativa, a painful inflammatory skin disease. The samples are stored in a biorepository for future research. The goal is to help scientists better understand and potentially find new treatments for this and ot…

This study looks at 720 children in pre-kindergarten and kindergarten to find the best way to teach them how to recognize and work with sounds in words. The goal is to improve their reading and spelling later on. The children will get one of two types of sound training, and resea…

This outcome of this study will elucidate how the phenotype of the individual modulates the KE metabolic effect. Most studies of KE have been in homogenous populations, usually young, male athletes. However, two striking experiments using identical, body weight adjusted KE doses …