Ohio State University

This study tests a new type of gum graft material (microsurfaced Acellular Dermal Matrix) against the standard material for treating gum recession. About 20 adults who need a gum graft will take part. The goal is to see if the new material leads to better healing, more root cover…

This study tests two programs—mindfulness exercises and a heart-healthy diet plan—to help Black women aged 40+ who care for a family member with Alzheimer's. Participants will learn stress-reduction techniques and healthy eating to lower blood pressure. The goal is to improve bot…

This study compares three ways emergency responders help critically ill children breathe: a bag-mask, a tube in the throat, or a device placed above the voice box. The goal is to see which method leads to more days alive and out of the ICU within 30 days. The trial involves 3,000…

This study tests a program where older kids mentor 7th graders with overweight or obesity to be more active, with extra support from parents. The goal is to help children in rural Appalachian areas increase their daily physical activity without needing special equipment. About 43…

This study tests whether a program that involves a family member or close friend can help African American adults with type 2 diabetes better manage their blood sugar and improve their quality of life. About 208 participants will work with a partner to learn diabetes self-care sk…

This study tests a program called B-SWELL, designed to help midlife Black women (ages 45-64) lower their heart disease risk by reducing stress and adopting healthier habits. Participants are randomly placed into either the B-SWELL program or a general wellness group, both lasting…

This study compares two types of implants used in spine surgery: a new titanium cage with a special rough surface and a standard plastic cage. About 100 adults with spine problems like narrowing of the spinal canal or worn-out discs will be randomly assigned to receive one of the…

This study looks at whether eating three soybean-oil-based foods each day for 16 weeks can reduce fat buildup in the liver and belly fat in people with nonalcoholic fatty liver disease. Participants keep their weight stable during the trial. The goal is to see if changing the typ…

This study looks at whether an 8-week mind-body course, called Mindfulness in Motion, can help university dance students feel less stressed, avoid burnout, and reduce injuries. About 40 second- and third-year dance students at Ohio State University will take the course as part of…

This study looks at whether a procedure called pancreatic endotherapy (using a thin tube through the mouth to treat the pancreas) can improve quality of life and reduce pain in people with chronic pancreatitis. About 32 adults with ongoing pain will be followed for a year. Resear…

This study looks at whether psilocybin, the active ingredient in magic mushrooms, can safely help veterans with PTSD. Fifteen U.S. military veterans aged 21-64 with PTSD will receive psilocybin alongside therapy. The goal is to see if it reduces PTSD symptoms and is safe to use.

This study looks at whether using a special breathing training device, along with standard physical therapy, can help people recover more quickly after a lung transplant. About 90 adults waiting for a lung transplant will take part. The goal is to see if the training improves bre…

This study tests whether a single, low-dose radiation treatment to the lungs can reduce inflammation in hospitalized adults with COVID-19 pneumonia. The goal is to see if this approach lowers the need for breathing machines and shortens hospital stays. About 37 participants will …

This study looks at whether a cochlear implant can safely and effectively help people hear again after surgery that leaves them deaf in one ear. Participants are having a benign tumor removed or a procedure for Meniere's disease that causes single-sided deafness. They will get a …

This study looks at different methods to help primary care clinics screen adults for substance use problems. It involves 144 clinic staff from 48 practices. Researchers compare coaching, team learning, and financial rewards to see which works best.

This study looks at whether giving Fitbit smartwatches to adults aged 65 and older in a doctor-referred exercise program helps them become more active. Researchers want to see if the program is easy to use and if participants like wearing the devices. The goal is to improve physi…

This study tests whether strawberry gummies can improve oral health in smokers and non-smokers. Researchers will measure how the mouth absorbs compounds from the gummies and check for changes in inflammation and genes. The goal is to see if these gummies are safe and might help p…

This study looks at whether tangerine tomatoes, which have a unique form of lycopene, are more easily absorbed by the body than regular red tomatoes. Researchers will measure how much of these nutrients get into the blood after eating tomato juice. The goal is to understand if ta…

This study watches how military members with back or neck pain move, using a wearable monitor. Researchers want to find patterns that predict who returns to full duty and who might get hurt again. About 400 adults aged 18-64 will answer surveys and do motion tests over one year.

This study looks at how pretzels made with safflower oil and soy affect energy use in overweight postmenopausal women with metabolic syndrome. Twenty women will eat different pretzels for one month each to see how their bodies process them. The goal is to learn if these snacks ca…

This study looks at whether giving staff financial bonuses for meeting goals helps them provide better substance use counseling to people with HIV. The study involves 428 participants and focuses on how consistently and well the counseling is delivered. It does not test a new tre…

This study tests whether an 8-week internet-based mindfulness program can improve brain health in 60 adults aged 50+ who have noticed memory or thinking declines. Participants will be randomly assigned to either the mindfulness program or a general lifestyle education program. Re…

This study looks at how eating foods made with soybean oil or palm oil for 4 weeks changes blood fats and body weight in overweight adults. Sixteen participants will eat three study foods each day and have their blood tested. The goal is to see if these oils affect health differe…

This study looks at what happens when healthy adults eat special cookies every day for two weeks. Researchers want to see if these cookies can increase a healthy fat called linoleic acid in the blood. The study involves 123 nonsmoking adults and measures changes in blood fats, bo…

This study tests whether a computer simulation can help pharmacists and pharmacy students better understand the pain struggles of sickle cell disease patients. About 200 healthcare professionals or students will use a point-of-view simulation and then complete surveys to see if t…

This study follows 400 adults who had skull base surgery through the nose. Researchers will measure quality of life and nose function for 2 years after surgery. The goal is to understand how modern surgical techniques affect long-term recovery and daily living.

This study looks at how chronic knee pain on both sides changes the way the brain recognizes left from right, and whether dry needling can affect movement and muscle function. Researchers will test 60 adults aged 18-40 with and without knee pain. Participants complete one 2-hour …

This study looks for better ways to measure fats and energy use in blood samples. Twenty-four healthy, non-smoking adults will give blood through a standard vein draw and finger pricks, both at the clinic and at home using a mail-in kit. The goal is to see if at-home finger-prick…

This study looks at how well a biointegrative implant helps heal the gluteus medius tendon after surgical repair. Fifteen adults with large tendon tears will receive the implant and be followed with ultrasound and questionnaires. The goal is to understand tissue healing and funct…

This pilot study tests whether eating one healthy cookie each day for two weeks can improve how your cells produce energy. Researchers will measure changes in mitochondria (the cell's power plants) in blood and muscle samples from 24 healthy, non-smoking adults. The goal is to se…

This study tests a new computer tool that uses maps to help infection preventionists find and stop the spread of infections in hospitals. About 25 infection experts will use the tool to see if it helps them spot infection clusters faster and better understand how infections sprea…

This study looks at millions of medical records to see if two common drug types (GLP-1 agonists and SGLT2 inhibitors) affect heart and kidney health differently in men versus women. Researchers will compare people taking these drugs to those on other medications. The goal is to f…

This study looks at how chemicals and social factors before birth affect brain function and mental health in teens aged 13-20. Researchers will use brain scans and behavior checklists in 250 adolescents to understand these links. The goal is to learn how early exposures may incre…

This study uses advanced heart MRI scans to look for the earliest signs of dilated cardiomyopathy (a weakened, enlarged heart) in close relatives of people already diagnosed with the condition. Researchers will scan 650 family members to see if certain genetic changes are linked …

This study checks whether a test that uses play to measure arm and hand movement in children with hemiplegic cerebral palsy is reliable when done through telehealth. About 35 children aged 2–10 will each attend one in-person visit and one video visit, playing with toys while bein…

This observational study looks at how diet, activity, and lifestyle factors relate to muscle strength, heart function, and overall outcomes in postmenopausal women treated for early-stage breast cancer with a specific type of chemotherapy. Researchers will measure heart and muscl…

This study looks at whether certain genes and thinking skills, like memory, can predict how well someone with aphasia (language problems after a stroke) responds to word-retrieval therapy. Researchers will work with 120 adults who had a stroke at least six months ago. The goal is…

This study follows 100 people aged 12 to 25 who are at high risk for psychosis to see if a step-based care program helps them recover and stay well. Researchers will track whether symptoms and daily functioning improve over time. The goal is to learn how well this clinical servic…

This study looks at how two common myopia treatments—low-dose atropine eye drops and soft multifocal contact lenses—change the shape of the eye in nearsighted young adults. About 75 participants will be randomly assigned to use one of these treatments or no treatment, and researc…

This study looks at how eating whole wheat bread changes gut bacteria and health markers in adults with prediabetes. Over two weeks, 65 participants will eat either whole wheat or white bread daily, then provide stool, urine, and blood samples. The goal is to understand how whole…

This study looks at how people's eyes move when they watch videos of a baseball pitcher throwing. Researchers want to see if experienced baseball players are better at moving their eyes to the ball release point before the pitch happens compared to people who don't play baseball.…

This study looks at how well blood sugar is controlled in pregnant women with gestational diabetes who are treated with either metformin or insulin. Researchers will use a continuous glucose monitor to track blood sugar levels during pregnancy and after childbirth. The goal is to…