Can a pretzel help menopausal women stay healthy? new study investigates
NCT ID NCT02199054
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looks at whether pretzels made with safflower oil and soy can help postmenopausal women with metabolic syndrome maintain a healthy weight. Twenty women will eat three different types of pretzels over 14 weeks, and researchers will measure how their bodies process the snacks. The goal is to learn more about how these ingredients affect blood fats, glucose, and natural soy chemicals called isoflavones.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- safflower oil and soy in pretzels
- What this could lead to
- If successful, this could point toward healthier snack options that help manage weight and reduce disease risk in menopausal women.
- What could go wrong
- This is a very small, early-phase study with only 20 participants, so results may not apply widely. The snacks are not a treatment for metabolic syndrome.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
About 20 people
The number the study aims to enrol. It can still change while the study runs.
- Started
-
Jul 2014
- Expected to finish
-
Apr 2027
An estimate. End dates often move.
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
45 to 70 years
- Sex
-
Female participants only
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Postmenopausal women 45 to 70 years of age * Stated to be postmenopausal and has a cessation of menstruation for greater than 12 months * Have a body mass index ≥25 kg/m2 * Must meet three of the five following criteria12 1. Have a waist circumference greater than 35 inches 2. Fasting serum triglycerides of greater than 150 mg/dL 3. Fasting high density lipoprotein (HDL) less than 40 mg/dL 4. Fasting blood glucose greater than 100 mg/dL 5. Systolic blood pressure greater than 130 mm Hg or diastolic blood pressure greater than 85 mm Hg * Agree to consume a standardized vitamin/mineral supplement and avoid other nutrition and alternative supplements for the duration of the study * Agree to follow a legume free diet and to document any accidental consumption of restricted foods each day of the study Exclusion Criteria: * Have an active metabolic or digestive illness including malabsorptive disorders, renal insufficiency, hepatic insufficiency, or had recent (within the year) gastrointestinal surgery. * Have a history or have active hormone related diseases of the pituitary, thyroid or pancreas that currently require supplemental hormonal administration thyroid hormones, adrenocorticotropic hormone (ACTH), growth hormone or other endocrine disorders requiring hormone or insulin administration * Have an active or a recent history of any condition that causes altered immunity such as chronic inflammatory disease, autoimmune disorders, cancer, anemia, and blood dyscrasias * Are on cholesterol lowering medications which include but not limited to statins, niacin (vitamin B3), bile-acid resins, fibric acid derivatives, or cholesterol absorption inhibitors. * Have a known allergy or food intolerance to ingredients in study products (wheat, soy, or safflower oil) * Are strict vegans (no consumption of animal, fish or egg products) * Are heavy alcohol consumers (defined as an average consumption of greater than 14 drinks/week) * Have a history of cancer or currently undergoing treatment for cancer * Have been on an antibiotic regime lasting for more than one week in the last 6 months * Are currently on another study for weight loss or trying to actively lose weight or recently (last 3 months) started medications for weight loss.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Metabolic syndrome are added.
Genom att skicka in godkänner du våra Användarvillkor
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The Ohio State University Wexner Medical Center Clinical Research Center
Columbus, Ohio, 43210, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Which exercise dose best helps kids with metabolic syndrome?
- Can a vegan diet shield police officers from heart disease?
- Can a weekly weight drug quiet gout attacks?
- Can 10-Minute school break videos get overweight kids moving?
- Weekly shot aims to melt away pounds in obesity fight
- Can a Once-Daily form of tacrolimus spare liver transplant patients from side effects?