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Can a better MRI scan help shrink pancreatic tumors for surgery?

NCT ID NCT06173310

Knowledge-focused Sponsor: Ohio State University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether a special MRI technique called DCE-MRI can guide chemotherapy for people with borderline resectable pancreatic cancer. The goal is to see if this imaging method can better track tumor blood flow and help doctors decide if the treatment is working, so they can switch therapies if needed. About 50 adults with newly diagnosed, untreated pancreatic cancer will participate. The study focuses on improving imaging accuracy, not on directly treating the cancer.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
DCE-MRI imaging with a portable perfusion phantom (P4 device)
What this could lead to
If successful, this imaging method could help doctors choose the most effective chemotherapy for each patient, potentially making more pancreatic tumors removable by surgery.
What could go wrong
This is a small, early-stage study focused on imaging accuracy, not treatment outcomes. The approach may not improve survival or surgical success rates.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 50 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2024

Expected to finish

Mar 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

19 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult patients (age 19 years or older). * Patients with newly diagnosed and untreated borderline resectable pancreatic cancer. * Patients with signed informed consent. Exclusion Criteria: * Any history of prior radiation or chemotherapy or surgical removal for pancreatic cancer. * Participants with safety contraindications to MRI examination (determined by standard clinical screening). * Participants who are pregnant, lactating or are planning to become pregnant during the study. * Participants who are planning to father a child during the study.

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Conditions

The condition(s) this trial relates to.

malignant pancreatic neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Borderline resectable pancreatic cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Indiana University Medical Center

    RECRUITING

    Indianapolis, Indiana, 46202, United States

  • The Ohio State University

    RECRUITING

    Columbus, Ohio, 43210, United States

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