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Plant protein swap may cut heart & diabetes risk – but how much?

NCT ID NCT02037321

Knowledge-focused Sponsor: John Sievenpiper Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is a review of many smaller trials that looked at what happens when people replace animal protein (like meat, dairy, eggs) with plant protein (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weight, and other markers of heart and diabetes risk. No new participants are being enrolled; instead, the researchers are combining data from past studies to get clearer answers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 1 person

The number the study aims to enrol. It can still change while the study runs.

Start date

May 2013

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Varied

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Dietary trials in humans * Randomized treatment allocation * \>=3 weeks * Suitable control (i.e. exchange with animal-protein) * Viable endpoint data Exclusion Criteria: * Non-human studies * Nonrandomized treatment allocation * \<3 weeks * Lack of a suitable control (i.e. no exchange with animal-protein)

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome acute kidney injury cardiovascular disorder diabetes mellitus Dyslipidemias gout hypertensive disorder impaired renal function disease Inflammation inflammatory disease inherited lipid metabolism disorder kidney disorder metabolic dysfunction-associated steatotic liver disease metabolic syndrome X Obesity obesity disorder Overweight prediabetes syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular disease Diabetes Dysglycemia Dyslipidemia Gout Hypertension Inflammation Kidney disease Kidney injury Metabolic syndrome Non-alcoholic fatty liver disease (NAFLD) Obesity Overweight Prediabetes

Contacts and locations

Locations

  • Toronto 3-D (Diet, Digestive tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital

    Toronto, Ontario, M5C 2T2, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.