CARDIOVASCULAR DISEASE

This study tests a new digital tool that helps doctors create personalized exercise plans for people with heart disease risk factors like high blood pressure, diabetes, and obesity. About 72 patients and 24 doctors will take part. The goal is to see if the tool is easy to use and…

This study looks at whether taking fish oil supplements along with the standard drug metformin can help protect the heart in women with Polycystic Ovary Syndrome (PCOS). PCOS often leads to high testosterone, which can cause blood sugar and cholesterol problems, raising the risk …

This study tests whether treating fatty heart plaques with a drug-coated balloon reduces their danger more than standard medications alone. About 400 adults with acute coronary syndrome will be randomly assigned to receive either the balloon treatment or no extra treatment during…

This large Phase 3 study tests a daily oral medication, AZD0780, to see if it reduces the risk of major heart problems like heart attacks, strokes, and urgent procedures in people with existing heart disease or those at high risk. About 15,100 participants will receive either AZD…

This study tests whether having a peer deliver blood pressure medication directly to patients' homes, combined with health technology, helps people take their pills regularly and lowers their blood pressure. About 1,140 adults with uncontrolled high blood pressure in western Keny…

This study tests whether anifrolumab, a drug already used for lupus, can improve blood vessel function and reduce inflammation in the arteries of people with lupus. About 45 adults with lupus will receive either the drug or a placebo over 8 months. The goal is to see if this trea…

This study looks at whether training doctors to quickly start and adjust four types of heart failure medications while patients are still in the hospital leads to better long-term treatment. About 438 adults with heart failure and reduced pumping ability will take part. The goal …

This study tests whether a year-long program combining blueberries, extra protein, and exercise can reduce frailty and lower heart disease risk in older adults. Researchers will enroll 240 people aged 65 and older who are willing to exercise. The goal is to see if this lifestyle …

This study tests whether empagliflozin, a drug used for diabetes, can protect the kidneys and heart in people who have had a heart transplant. About 200 veterans will receive either the drug or a placebo daily for 12 months. The goal is to see if it improves kidney function and r…

This study tests a drug called olpasiran in people with stable heart disease and high levels of lipoprotein(a), a genetic risk factor. The goal is to see if olpasiran can reduce non-calcified plaque in the heart arteries compared to a placebo over 72 weeks. About 406 adults aged …

This study looks at whether taking omega-7 oil (found in fish and macadamia nuts) can improve cholesterol levels and help with appetite control. Researchers will give healthy adults omega-7 supplements for 24 weeks and track changes in their blood fats and eating habits. The goal…

This study tests a special mattress that tracks heart rate, breathing, body temperature, and movement without any wires or sensors touching the patient. It involves 1,100 adults hospitalized for heart problems. The goal is to see if this non-contact system can help doctors monito…

This study tests whether olpasiran can prevent first major heart problems (like heart attacks or urgent procedures) in people aged 50+ who have high levels of lipoprotein(a), a genetic risk factor. About 11,000 participants will receive either olpasiran or a placebo. The goal is …

This large study in Denmark will give the shingles vaccine (Shingrix) to about 162,000 adults aged 65 and older to see if it also prevents heart attacks, strokes, and dementia. Half will get the vaccine, half will not. Researchers will track health records for several years to co…

This study works with churches in Washington D.C. to understand heart health in the Black community. About 200 adults will get a health exam, including blood pressure, cholesterol, and blood sugar tests. They will also wear an activity monitor for a month. The results will help d…

This study looks at how nutrition after heart surgery affects gut bacteria and recovery. Researchers will measure certain chemicals made by gut bacteria in 30 heart surgery patients. The goal is to see if a special diet or probiotics can improve health outcomes after surgery.

This study brings together health data from about 3 million adults across 40 countries to see how common risk factors like high blood pressure, smoking, and diabetes affect heart disease and death rates. Researchers want to learn if these risks differ by geographic region and sex…

This study follows 155 adults with CADASIL, a genetic condition that narrows small blood vessels and can cause strokes and dementia, over 9 years. Researchers will track changes in blood vessels, brain scans, and thinking abilities through four visits. The goal is to learn how th…

This study collects blood, saliva, skin, or tissue samples from people with rare genetic blood vessel or heart diseases, as well as from healthy relatives. The goal is to find the genetic causes and understand how these diseases work. No treatment is given—only samples are taken …

This study looks at how exercise affects brain activity and blood vessel inflammation in people with PTSD who also have or are at risk for heart disease. Researchers will use a special imaging technique (PET/MRI) to measure changes in the arteries and bone marrow. The goal is to …

This study tests a new way to use a standard PET scan tracer (FDG) to measure both blood flow and sugar use in the heart at the same time. Researchers will compare these measurements to those from a separate tracer that only measures blood flow. The goal is to simplify heart imag…

This study surveys 200 adults with existing heart or blood vessel disease to see how well they recognize their risk factors and perceive their chance of having another heart problem. Researchers want to compare awareness between women and men. The goal is to find gaps in understa…

This study aims to find the genetic causes of primary aldosteronism—a condition where an adrenal gland tumor causes high blood pressure—in Black individuals. Researchers will study up to 1,150 participants, including those with hard-to-control blood pressure and their relatives. …

This study looks at how a beta-blocker drug changes the body's stress response, focusing on inflammation and brain activity. Researchers will give the drug or a placebo to 120 healthy adults aged 18-30 and measure their immune markers and brain scans during a stressful task. The …

This study is an early test of a new drug called Fx-5A, which may one day help treat heart disease and inflammation. It involves 64 healthy adults who receive a single dose of the drug and are monitored for safety and side effects over about 5 to 10 weeks. The goal is to gather i…

This study looks at how whole milk versus skim milk affects blood sugar and cholesterol in healthy adults. Researchers will ask 100 participants to drink only whole milk for a period, then switch to skim milk (or the other way around). The goal is to see if the fat content in mil…

This study aims to develop and test new MRI methods for imaging the heart and blood vessels to improve diagnosis and management of heart failure. It will involve up to 3,400 adults, including both patients with heart conditions and healthy volunteers. Participants will undergo st…