CARDIOVASCULAR DISEASE

This study tested whether a smartphone app and phone calls could help people with heart disease do rehab at home instead of going to a clinic. 258 veterans took part. The goal was to see if this approach improved their ability to exercise, helped them stick with the program, and …

This study tested whether a low-dose blood thinner called rivaroxaban could lower the risk of major heart problems (like heart attack or stroke) in people with advanced chronic kidney disease or kidney failure on dialysis. About 1,753 participants were randomly assigned to receiv…

This study tested whether taking a probiotic supplement for 6 weeks could improve blood vessel function and reduce inflammation in 215 adults with heart disease or type 2 diabetes. Researchers measured blood markers and gut bacteria to see if changing gut health might lower heart…

This study looked at whether tildrakizumab, a medicine for moderate-to-severe psoriasis, can improve blood flow to the heart. Psoriasis is linked to higher heart disease risk, and this research tested if reducing inflammation with tildrakizumab helps heart function. 36 adults wit…

This study looked at whether a newer type of dialysis called 'online hemodiafiltration' is better tolerated and reduces heart problems compared to standard high-flux hemodialysis. It involved 415 adults over 65 with advanced kidney failure who had been on dialysis for at least 3 …

This study tested a nurse-led program to help veterans with HIV lower their blood pressure and reduce their risk of heart disease. About 305 veterans took part, receiving either the nurse-led program or standard education. The program used video calls and care coordination to mon…

This early-stage study tested a new medicine called AMG 890 in about 80 people with high levels of lipoprotein(a), a genetic risk factor for heart disease. The main goal was to check the drug's safety and how the body processes it. Participants received a single dose of the drug …

This study tested a new medicine called olpasiran in 281 adults with high levels of lipoprotein(a), a genetic risk factor for heart disease. Participants received either the drug or a placebo as a shot under the skin. The main goal was to see if olpasiran could safely lower lipop…

This study tested whether injecting donor stem cells into the leg muscles of people undergoing major leg amputation could prevent wound complications and reduce the need for further amputations. 81 adults aged 40-90 with severe artery disease received stem cell injections above a…

This large study tested whether taking daily cocoa extract (from the cocoa bean) and/or a standard multivitamin could lower the risk of heart disease and cancer in older adults. Over 21,000 men and women aged 60+ took the supplements for several years. Researchers tracked heart a…

This study tested a 9-week internet-based therapy program designed to reduce stress, anxiety, and depression in people with heart disease. 215 adults with stable heart conditions and mild to moderate psychological distress took part. The program was personalized and guided by a t…

This study looked at whether eating whole eggs (with cholesterol) helps adults aged 50-69 gain more muscle from resistance training compared to eating only egg whites. About 36 participants did strength training and ate either whole eggs or egg whites. Researchers measured muscle…

This study tested whether changing the fat profile of milk (by altering cows' diets) could affect heart disease risk factors in healthy adults. 107 volunteers consumed different milk fats with varying levels of natural trans fats. Researchers measured cholesterol and other blood …

This study examined whether a diagonal crease on the earlobe, known as Frank's sign, is more common in smokers and could help spot early signs of heart disease. Researchers compared 404 adults aged 40-59 who were current, former, or non-smokers. The goal was to see if this simple…

This study used national health data to estimate how many US adults might be eligible for a new cholesterol-lowering drug called inclisiran. Researchers looked at people with high cholesterol despite taking statins and calculated how many heart attacks and strokes could be preven…

This study looked at 80 childhood cancer survivors who had received strong chemotherapy (anthracyclines) and were now cancer-free for at least 2 years. Researchers used special heart MRI scans and blood tests to find early, symptom-free heart damage that standard tests might miss…

This study looked at 74 adults with active rheumatoid arthritis (RA) who had never taken biologic drugs. Researchers used heart scans to measure how well the heart's blood vessels work, aiming to understand if reducing inflammation lowers heart risk. The goal was to learn whether…

This study looked at how psoriasis, a skin condition caused by inflammation, might be linked to heart disease and other metabolic problems. Researchers followed 386 adults with psoriasis for up to 4 years, using blood tests, heart scans, and imaging to measure inflammation in blo…

This study looked at how two types of trans fats—one from milk and one from processed oils—affect heart disease risk in 46 healthy adults. Participants ate special foods with either natural or artificial trans fats for a set time, then switched. The main focus was on changes in "…

This study looked at how different types of diets affect the number of calories people burn and their risk for diseases like diabetes and heart problems. 234 adults who were overweight or obese took part. Researchers measured their total energy use and resting metabolism to under…

This study looked at how stretchy the skin and blood vessels are in people with Williams syndrome, a genetic condition that can cause heart problems. Researchers measured skin and pulse speed in 43 participants aged 5 to 70. The goal was to learn how these tissues change over tim…

This study collected DNA, tissue, and medical history from 305 people with Williams syndrome or supravalvar aortic stenosis (SVAS), as well as their family members and healthy volunteers. The goal was to create a resource for future research into why symptoms vary so much from pe…

This study looked at whether newer psoriasis medications (IL17 and IL23 inhibitors) can also help reduce early signs of heart disease. Researchers measured artery stiffness in 66 patients with moderate-to-severe psoriasis before and after one year of treatment. The goal was to se…

This study looked at how Mexican-American families discuss their risk for diabetes, heart disease, breast cancer, and colon cancer. Researchers interviewed 498 adults from Houston-area households to understand how culture and family relationships help or hinder health conversatio…

This study explores how specific gene variations influence the health of blood vessels in 178 healthy adults. Participants had a single visit for blood tests, urine samples, and an ultrasound to measure blood flow after a short-acting medication. The goal is to better understand …

This study looked at 99 adults with high heart disease risk to understand how a protein called CETP affects plaque buildup in arteries. Researchers measured CETP activity and used imaging to check artery thickness and calcium. The goal was to learn if CETP can serve as a marker f…

This study looked at how stiff blood vessels in people with Williams Syndrome or supravalvular aortic stenosis (SVAS) affect organs like the heart, brain, kidneys, and gut. Researchers followed 159 participants (ages 3-85) for up to 10 years using imaging, blood tests, and cognit…

This study looked at how long-term lack of sleep affects heart health and weight in women. Researchers compared women before and after menopause to see if sleep loss leads to higher blood pressure, worse blood sugar control, and more belly fat. The goal was to understand these ri…

This study looked at 20 people with CADASIL, a rare genetic disease that damages arteries in the brain and can cause migraines, strokes, memory loss, and dementia. The goal was to learn more about how the disease works by doing detailed exams, brain scans, and lab tests over two …

This study looked at 50,000 living kidney donors in Canada to see if they have a higher risk of heart problems or death later in life compared to similar people who didn't donate. Researchers used health records from 1992 to 2024 to track heart attacks, strokes, and deaths. The g…

This study looked at 70 breast cancer survivors to see how their physical activity levels relate to heart disease risk. Participants wore a special armband to track activity and had their heart risk scored. The goal was to gather information on whether staying active can help pro…

This study looked at whether inflammation is linked to heart disease and diabetes. Researchers compared 150 adults with these conditions to healthy volunteers using blood tests, heart scans, and tissue samples. The goal was to better understand the relationship, not to test a new…

This study looked at how family members talk about genetic health risks like sickle cell, diabetes, cancer, and heart disease. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand how sharing this information …

This study looked at whether giving veterans their genetic test results could help doctors better manage heart disease. 112 veterans with certain gene changes were followed for 6 months to see if their cholesterol levels improved. The goal was to learn how to return genetic infor…