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Earlobe crease may signal hidden heart danger in smokers

NCT ID NCT07427745

Knowledge-focused Sponsor: Samsun University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study examined 404 adults aged 40-59 to see if a diagonal crease on the earlobe, known as Frank's sign, is more common in smokers. Researchers took ear photos and recorded medical histories. The goal was to see if this simple, non-invasive sign could help doctors quickly identify people at higher risk for cardiovascular disease due to smoking.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If confirmed, this simple ear check could help doctors quickly spot people at higher risk for heart disease.
What could go wrong
This is a small, completed observational study, not a treatment trial. The link between Frank's sign and smoking is not proven to predict heart disease in all groups.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

404 people

The number who actually took part.

Started

Sep 2024

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consisted of all individuals aged 40-59 years presenting to the clinics of the Department of Family Medicine at Samsun University Faculty of Medicine (Smoking Cessation, Family Medicine, Traditional and Complementary Medicine, Home Health Services, and Obesity Clinics)

Ages

40 to 59 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Individuals aged 40-59 years who presented to the relevant outpatient clinics were included in the study. Exclusion Criteria: * The exclusion criteria included being outside the specified age range, the presence of an earring or piercing on the earlobe, a history of trauma affecting the integrity of the ear, the presence of soft tissue diseases, or ear malformations.

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Conditions

The condition(s) this trial relates to.

cardiovascular disorder Cigarette Smoking Smoking

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiovascular disease Smoking ( cigarette)

Contacts and locations

Locations

  • Samsun University Training and Research Hospital (Samsun City Hospital)

    Samsun, Turkey (Türkiye)

More trials for these conditions

Other studies related to the condition(s) this trial covers.