New scan may spot hidden heart harm in childhood cancer survivors

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

5.1 A. Subject Inclusion Criteria * Childhood cancer survivors from the late effect clinic who had received ≥240 mg/m2 anthracyclines, been in complete remission and off chemotherapy for a minimum of 2 years. * Age \> 9 years of age\* * Parental/caregiver consent and subject assent to enrollment \* Age \> 9 years of age was chosen to avoid the need for general anesthesia or sedation B. Subject Inclusion Criteria * Enrolled in part A of the study, which took place from October 2011 to July 2013. * Parental/caregiver consent and subject assent to enrollment C. Subject Inclusion Criteria * Childhood cancer survivors from the late effect clinic who had received \< 300 mg/m2 anthracyclines, been in complete remission and off chemotherapy for a minimum of 1 year * Age ≥ 9 years of age\* * Parental/caregiver consent and subject assent to enrollment * \* Age \> 9 years of age was chosen to avoid the need for general anesthesia or sedation 5.2 A. Subject Exclusion Criteria * Contraindications to CMRI.\* * Pregnancy\*\* \* Contraindications to CMRI (i.e., magnetically activated implants/devices; cardiac pacemaker or wires; after the patients are scheduled for CMRI, they will be sent our standard pre-MRI paperwork/questionnaire, to determine eligibility to have an MRI) \*\*If a female patient of child bearing age is not sure if they are pregnant or not, as part of the standard CMRI with contrast procedures, a urine pregnancy test will be done. If the result is positive the subject will not be allowed to continue in the study. CMRI with gadolinium may affect a fetus, and also the CMRI results are an integral part of this research study. * Orbital X-Ray confirmed to have metal in the eye or patient confirmed to have metal in the eye. B. Subject Exclusion Criteria * Not enrolled in part A of the study * Contraindications to CMRI\* * Pregnancy \*\* * Orbital X-Ray confirmed to have metal in the eye or patient confirmed to have metal in the eye * C. Subject Exclusion Criteria * Total Cumulative dose anthracyclines ≥300 mg/m2 * Contraindications to CMRI\* * Pregnancy \*\* * Orbital X-Ray confirmed to have metal in the eye or patient confirmed to have metal in the eye Exclusion Criteria: * Contraindications to CMRI * Relapse of their cancer * Pregnancy