Scientists probe Inflammation's role in heart disease and diabetes

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* Cardiovascular Disease Eligibility Criteria INCLUSION CRITERIA: * Females and males 18 years of age or older * Diagnosis of clinical CAD (including abnormal EKG with a prior infarction pattern, abnormal echo consistent with a wall motion abnormality or a referral note from cardiologist with diagnosis of CAD) * CAD that is currently stable (defined by no change in medications for blood pressure, angina or diuretic therapy or in no new CV symptoms over the past month in a patient who has had a primary cardiac event or an abnormal EKG with confirmed wall motion abnormality) * CAD which may be associated with chronic stable angina (defined by a clinical syndrome characterized by discomfort in the chest, jaw, shoulder, back, or arm by a physician). * CAD that is found on CCTA which may be subclinical EXCLUSION CRITERIA: * Pregnant women or lactating women. * For optional adipose biopsy, any subject with known bleeding disorder, current fever or on anti-coagulation. * For optional MRI, inability to participate due to metal within body, claustrophobia, or anything else that prohibits undergoing a MRI scan * Any solid organ or liquid tumor within the past five years, with the exception of nonmelanomatous skin cancer, * Active infectious diseases within 3 months requiring antibiotics, collagen vascular diseases such as RA, psoriasis and mixed connective tissue diseases and immune-mediated lung diseases (e.g. IPF, BOOP) * A BMI \>40 kg/m(2) due to PET MRI restrictions * Subjects with severe renal excretory dysfunction, estimated glomerular filtration rate \< 30 mL/min/1.73m(2) body surface area according to the Modification of Diet in Renal Disease criteria, will not receive the cardiac CT angiography, or gadolinium contrast agent during the PET/MRI. Diabetes Mellitus Eligibility Criteria INCLUSION CRITERIA: * Females and males 18 years of age or older * Diagnosis of type 2 diabetes mellitus (DM), currently stable as defined by no change in antidiabetic medications over the past month and fasting glucose \<200 EXCLUSION CRITERIA: * Pregnant women and or lactating women. * For optional adipose biopsy, any subject with known bleeding disorder, current fever or on anti-coagulation. * For optional MRI, inability to participate due to metal within body, claustrophobia, or anything else that prohibits undergoing a MRI scan * Any solid organ or liquid tumor within the past five years, with the exception of nonmelanomatous skin cancer, * Active infectious diseases within 3 months requiring antibiotics, collagen vascular diseases such as RA, psoriasis and mixed connective tissue diseases and immune-mediated lung diseases (e.g. IPF, BOOP) * A BMI \>40 kg/m(2) due to PET MRI restrictions * Subjects with severe renal excretory dysfunction, estimated glomerular filtration rate \< 30 mL/min/1.73m(2) body surface area according to the Modification of Diet in Renal Disease criteria, will not receive the cardiac CT angiography, or gadolinium contrast agent during the PET/MRI. * Subjects with second -or third-degree AV block or sinus node dysfunction will not receive the 13N-ammonia PET/CT imaging unless these patients have a functioning artificial pacemaker. * Subjects with any signs or symptoms of acute coronary syndrome, including vasoreactive hypertension with blood pressure exceeding 180/100, any concerning ST segment changes on ECG, or acute chest pain, will not receive the 13N-ammonia PET/CT imaging. Healthy Volunteers: INCLUSION CRITERIA: -Females and males 18 years of age or older without any clinical diagnosis of a chronic health condition that is knownto accelerate vascular disease beyond traditional risk factors including lung disease or active infection EXCLUSION CRITERIA: * For imaging studies, pregnant women * For imaging studies, lactating women * For optional MRI, inability to participate due to in optional MRI metal within body, claustrophobia, or anything else that prohibits undergoing a MRI scan * Any solid organ or liquid tumor within the past five years, with the exception of non melanomatous skin cancer, * Active infectious diseases within 3 months requiring antibiotics, collagen vascular diseases such as RA, psoriasis and mixed connective tissue diseases and immune-mediated lung diseases (e.g. IPF, BOOP) * Clinical diagnosis of diabetes or cardiovascular disease * Fasting glucose \>125, * LDL\>200, * LFT s 3 times normal limit, * eGFR\<60, * Subjects with severe renal excretory dysfunction will not receive the cardiac CT angiography, or gadolinium contrast agent during the PET/MRI. * A BMI \>40 kg/m(2) due to PET MRI restrictions.