National Heart, Lung, And Blood Institute (nhlbi)

This study is testing a second stem cell transplant for people with sickle cell disease or beta-thalassemia whose first transplant is starting to fail. The goal is to cure the disease by making more room in the patient's bone marrow for healthy donor cells. The trial is for patie…

This study is testing a new, less invasive procedure called TRAIPTA for people with a leaky tricuspid heart valve. The procedure involves placing a special loop, like a belt, around the heart through a vein in the leg to help the valve close better and reduce leakage. It is for a…

This study is testing whether a pill called baricitinib can slow or stop the progression of brain and spine lesions in people with Kohlmeier-Degos disease, a rare and often fatal condition that causes blockages in small blood vessels. Twelve adults with neurological involvement f…

This study is testing if a dietary supplement called nicotinamide riboside (NR), a form of vitamin B3, can help control lupus. Researchers will give NR or a placebo to 78 women with lupus for 12 weeks to see if it calms a specific part of the overactive immune system linked to th…

This study is testing whether a smartphone app, combined with remote coaching, can help Black women increase their physical activity to reduce obesity and improve heart health. Researchers are recruiting 325 overweight or obese African American women in specific Washington, D.C.,…

This study is testing a modified stem cell transplant procedure for people with severe blood disorders like aplastic anemia. Researchers are adjusting how donor cells are collected and given to try to reduce serious side effects while still successfully replacing the patient's fa…

This study is testing whether a mobile app designed for couples can help people with obstructive sleep apnea use their CPAP machine more consistently. It involves 360 couples where one partner has sleep apnea and is starting CPAP treatment. The couples will use the app to access …

This study is testing a stem cell transplant from a partially matched family member for people with severe aplastic anemia, myelodysplastic syndrome (MDS), or paroxysmal nocturnal hemoglobinuria (PNH). These are serious disorders where the bone marrow fails to make enough healthy…

This is an early safety study to see if a pill called fostamatinib is safe and tolerable for adults with stable sickle cell disease. Up to 25 participants will take the drug at home for 6 weeks, with visits every 2 weeks to check for side effects. The main goal is to find a safe …

This study is testing whether a low dose of the hormone drug danazol can help people with telomere diseases. These rare conditions cause accelerated cellular aging, leading to problems with bone marrow, lungs, and liver. Researchers will give the drug for one year to 40 participa…

This study is testing whether a concentrated omega-7 fish oil supplement can improve cholesterol levels and reduce feelings of hunger in healthy adults. Over 24 weeks, 110 participants will take either the omega-7 oil or a control olive oil to see which one better lowers 'bad' LD…

This study is testing if starting two oral medications (cyclosporine and eltrombopag) at home soon after diagnosis can help control severe aplastic anemia, a rare and serious blood disorder, while patients prepare for standard hospital treatment. Researchers want to see if this e…

This study is testing whether the drug ruxolitinib can help adults whose immune system is attacking their bone marrow, causing severe blood diseases like aplastic anemia. Participants will take the pill twice daily for up to six months while researchers monitor their blood counts…

This study is testing a new method for umbilical cord blood transplants in people with severe aplastic anemia or myelodysplastic syndrome (MDS), which are serious bone marrow diseases. Researchers are using specially prepared, expanded cord blood cells to try to help the transpla…

This study is testing a new blood test that looks for tiny pieces of DNA from a donor organ in a transplant patient's blood. The goal is to see if this test can detect early signs of organ rejection before serious damage occurs, potentially replacing the need for frequent, invasi…

This study is testing new, lower-radiation methods for heart CT scans in 5,000 adults who need heart imaging. Researchers want to see if these safer scans are just as accurate for detecting heart disease and predicting patient outcomes. The study also aims to validate new imaging…

This study aims to develop and test new MRI scanning methods to improve how doctors diagnose and monitor heart disease. It will enroll 3,400 adults, including both people with known or suspected heart conditions and healthy volunteers, who will undergo MRI scans and be followed f…

This study is testing a new version of an MRI scanner that uses lower energy to take pictures of the heart and other body parts. The goal is to see if this new scanner can create images as good as standard machines while being safer for people who have metal medical devices insid…

This study aims to find out if a breathing medicine called albuterol works better for women with a rare lung disease (LAM) when given through a nebulizer machine versus a standard inhaler. Researchers will measure lung function in about 100 women over three days to see which meth…

This study aims to find better ways to detect early lung inflammation and scarring in people who receive a stem cell transplant from a donor. Researchers will regularly test 40 participants with special low-radiation chest scans, lung fluid collection, and blood tests for two yea…

This study collects blood, cheek cell, and bone marrow samples from healthy volunteers to support laboratory research. The samples help scientists study how blood cells form normally, investigate viral blood diseases, and understand genetic risk factors for conditions like aplast…

This study aims to understand why some people are more prone to lung infections than others. Researchers will collect fluid and tissue samples from the lungs and noses of 550 healthy volunteers and people with a history of infections. By comparing these samples, they hope to find…

This study aims to understand why people with tuberous sclerosis develop non-cancerous skin tumors. Researchers will enroll 400 adults with the condition to examine their skin and collect small tissue samples (biopsies) from up to eight tumors. The goal is to analyze these sample…

This study aims to collect blood, bone marrow, urine, and tissue samples from patients with cancer or blood disorders, as well as from some of their family members. The samples will be used in laboratory research to help scientists better understand these diseases, evaluate curre…

This study aims to understand how platelets—the cells that help blood clot—normally function in healthy people and how they change over time. Researchers will follow 400 healthy adults for 10 years, collecting blood samples and health information every six months. The goal is to …

This study aims to understand the heart health and weight-related needs of adults in Washington D.C. area churches. Researchers will collect health information from 200 participants to learn about risk factors like blood pressure, cholesterol, and activity levels. The data will b…

This is an early safety study to test a new drug called Fx-5A, which researchers hope could one day help treat heart disease and inflammation. The study involves 64 healthy volunteers who will receive a single dose of the drug through an IV. The main goal is to see how safe the d…

This study aims to develop better methods for preparing donor blood cells for bone marrow transplants. Researchers are working with healthy volunteers to collect blood cells and test ways to remove the white blood cells that can cause dangerous immune reactions in transplant pati…

This study follows patients for years after they received a donor stem cell transplant to understand the long-term health effects. Researchers monitor for disease return, transplant complications, and late side effects from the original treatment. Participants undergo regular che…

This study aims to better understand how sickle cell disease develops and causes complications like pain crises over a person's lifetime. Researchers will observe and collect health information from 3,500 participants over time, but will not test any new treatments. The goal is t…

This study is creating a collection of DNA, tissue samples, and health information from people with Williams syndrome or supravalvar aortic stenosis (SVAS) and their family members. Researchers want to understand why these genetic conditions affect people so differently, even whe…

This study aims to learn more about bronchiectasis, a lung condition that causes repeated infections and breathing problems. Researchers will follow 900 patients and some of their family members over time, collecting health information and samples like blood and sputum. The goal …

This study aims to collect blood and tissue samples from people to help researchers understand the genetic causes of rare vascular and heart diseases. It involves 10,000 participants of all ages who will donate samples like blood, saliva, or small skin biopsies. The goal is to bu…

This study aims to develop and test new MRI scanning methods to improve how doctors see and understand heart and blood vessel diseases. Researchers will scan up to 5,000 healthy volunteers and people with known or suspected heart conditions, including children as young as 7. A ke…

This study aims to learn how the drug venetoclax affects cancer cells and the immune system in people with chronic lymphocytic leukemia (CLL). Researchers will observe 75 adults with relapsed CLL as they start treatment, tracking genetic changes in the cancer over time. The goal …

This study is testing whether new CT scan methods that use less radiation can produce images that are just as good as traditional CT scans. Researchers are enrolling adults who are already scheduled for chest, abdomen, or pelvis CT scans. During their regular scan appointment, pa…

This study aims to understand how genes contribute to the development of various lung diseases, including cystic fibrosis, asthma, and pulmonary fibrosis. Researchers will collect genetic information from up to 3,500 participants, including people with these conditions and health…

This study aims to understand why some people with sickle cell disease have more severe symptoms than others. Researchers are looking at a specific gene called PKLR to see if different versions of it affect how red blood cells work, which could worsen the disease. They will colle…

This study aims to understand the long-term health journey of people with rare bone marrow failure diseases. Researchers will follow 1,000 participants, including some family members, for up to 20 years to see how these diseases and their treatments affect the body over time. The…

This study aims to understand what causes Lymphangioleiomyomatosis (LAM), a rare and serious lung disease that mostly affects women. Researchers will study the genes and proteins in people with LAM to learn how the disease damages the lungs. The goal is to use this knowledge to d…

This study aims to learn more about rare and poorly understood diseases that affect the heart and blood vessels. Researchers will enroll up to 5,000 people, including patients, their relatives, and healthy volunteers, to collect medical data, images, and samples. The goal is to i…

This study aims to collect blood samples from healthy adults to help researchers better understand and test for blood vessel and immune system diseases. Researchers will use these samples to establish what 'normal' looks like, which helps them develop more accurate tests and stud…

This study aims to understand how well vaccines work in adults with certain blood cancers like chronic lymphocytic leukemia and non-Hodgkin lymphoma. Researchers will measure immune responses to vaccines for illnesses like COVID-19, hepatitis B, and shingles. They will also test …

This study aims to learn more about rare genetic diseases that affect the heart and blood vessels. Researchers are recruiting up to 1,000 people, including patients, their family members, and healthy volunteers, to collect medical information and samples like blood and tissue. Th…

This study aims to better understand how disorders of blood fats (like cholesterol) develop over time and contribute to heart and blood vessel diseases. Researchers will observe and perform detailed blood tests on up to 2,000 people who have unusually high or low levels of these …

This study aims to understand how long red blood cells survive in people with sickle cell disease, thalassemia, and other inherited blood disorders. Researchers will label a small sample of a participant's own blood cells with a safe vitamin (biotin) and track them over several m…

This study aims to understand how the drug pirtobrutinib affects the immune system when used as a first treatment for chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Researchers will enroll about 30 adults with untreated CLL or SLL to take the drug daily a…

This is the very first time a new drug called ZMA001 is being given to people. Researchers want to see if it is safe and how it moves through the body in healthy volunteers. The drug is being developed to treat pulmonary arterial hypertension (PAH), a severe lung disease where mo…

This study aims to discover the genetic causes of severe combined immunodeficiency (SCID), a rare condition where the immune system doesn't work properly. Researchers will analyze blood samples from 100 participants, including patients with SCID and their relatives, to identify s…

This study aims to understand how CADASIL, a genetic disorder that damages small blood vessels and can lead to strokes and dementia, changes over time. Researchers will follow about 100 people with CADASIL and 40 healthy volunteers for 9 years, performing detailed tests on their …

This early-stage study is testing whether a daily supplement containing a natural sugar from human milk can increase beneficial gut bacteria and improve markers linked to heart health. It will enroll 100 healthy adults who eat a typical Western diet. Participants will take the su…

This study aims to understand how certain leukemia and lymphoma drugs, called BTK inhibitors, affect the heart and may increase the risk of dangerous irregular heartbeats. Researchers will monitor 135 adults who are already taking or planning to start these drugs, using heart tes…

This study aims to understand how organs like the heart, brain, kidneys, and lungs recover in adults with sickle cell disease after they receive treatments intended to cure the condition. Researchers will compare 200 participants—some receiving curative therapies and others conti…

This study aims to understand how a person's neighborhood environment—like poverty, crime, and disorder—affects stress levels and biological markers of heart disease risk in women. Researchers will recruit 250 healthy women in Washington, DC, to measure their stress, physical act…

This study aims to understand how certain genetic changes in blood cells, which can increase the risk of blood cancers and heart disease, develop over time. Researchers will follow about 300 adults with these changes for up to 10 years, performing regular health checks and scans.…

This study aims to learn how certain blood cancers develop and change over time. Researchers will follow up to 1,000 adults who have been diagnosed with these conditions, collecting blood and tissue samples regularly. The goal is to understand the biology of these diseases to hel…

This study aims to better understand rare, often inherited disorders that cause abnormal levels of fats like cholesterol in the blood. Researchers will observe how these conditions change over many years and how patients respond to their regular treatments. The goal is to gather …

This study aims to better understand how diseases involving blood clots, inflammation, and blood vessels start and progress over many years. Researchers will observe 1,000 participants, including people with these conditions, their healthy relatives, and unrelated healthy volunte…