National Heart, Lung, And Blood Institute (nhlbi)

This study tests whether nicotinamide riboside, a form of vitamin B3, can reduce inflammation and improve immune function in women with mild-to-moderate lupus. About 78 women will receive either the supplement or a placebo for 12 weeks. Researchers will measure changes in immune …

This study tests a new way to do stem cell transplants for people with severe aplastic anemia or a related bone marrow disease called MDS. Participants get a mix of stem cells from a family member and specially grown cord blood cells from an unrelated donor to help the new cells …

This study tests a partial stem cell transplant for people with severe sickle cell disease or beta-thalassemia who need regular blood transfusions. The goal is to get more donor cells to stay in the body long-term, which could reduce disease complications. About 90 participants w…

This study tests if a low dose of the hormone drug danazol can safely slow down telomere shortening in people with telomere diseases. Telomeres are protective caps on our DNA that get shorter as we age, and people with certain gene changes can develop serious bone marrow, lung, o…

This study tests whether a stem cell transplant using blood stem cells from a half-matched family member (haploidentical donor) can safely treat severe aplastic anemia, a related bone marrow disorder (MDS), and a blood cell disease (PNH). Participants receive chemotherapy and a o…

This study tests whether mobile health technology, like smartphone apps and activity trackers, can help overweight or obese African American women in low-resource areas increase their physical activity. About 325 women aged 21-75 from specific neighborhoods near Washington, DC wi…

This study tests a pill called ruxolitinib for adults whose immune system attacks their bone marrow, causing conditions like severe anemia. The drug aims to calm the immune attack and improve blood cell counts. Participants take the pill twice daily for up to 6 months and are mon…

This study tests a second stem cell transplant for people with sickle cell disease or beta-thalassemia whose first transplant didn't fully work. Participants receive a second infusion of donor stem cells to increase the number of healthy donor cells in their bone marrow. The goal…

This study tests whether starting two oral drugs (cyclosporine and eltrombopag) early, at lower doses, is safe and practical for people with severe aplastic anemia, a rare blood disorder. Participants aged 3 and older take these drugs for 6 months, then may receive standard thera…

This study tests whether baricitinib, an FDA-approved drug for other conditions, can help people with Kohlmeier-Degos (KD) disease that affects the brain and spine. KD is a rare, life-threatening disease causing inflammation and blood clots in small vessels. The trial will enroll…

This study is testing a new way to do stem cell transplants for people with severe aplastic anemia or other bone marrow failure diseases. The goal is to reduce serious side effects, like graft-versus-host disease, by giving fewer donor white blood cells along with the stem cells.…

This study looks at whether taking omega-7 oil (found in fish and macadamia nuts) can improve cholesterol levels and help with appetite control. Researchers will give healthy adults omega-7 supplements for 24 weeks and track changes in their blood fats and eating habits. The goal…

This study tests whether a couple-focused mobile health program helps people with sleep apnea use their CPAP machine more consistently. About 360 newly diagnosed patients and their partners will receive supportive resources on their phones for six months. The goal is to improve C…

This early-stage study tests a drug called fostamatinib in 25 adults with stable sickle cell disease to see if it is safe and tolerable. Participants take the pill twice daily for up to 6 weeks, with regular checkups. The goal is to find a safer way to prevent blood clots in peop…

This study tests whether a nebulizer or a standard inhaler (MDI) delivers albuterol better to improve lung function in women with LAM, a rare progressive lung disease. About 100 women with LAM and breathing problems will stay overnight for 3 days to try each method. The goal is t…

This study aims to see if newer CT scanning methods that use less radiation can create images just as clear as traditional CT scans. Researchers will enroll 215 healthy adults who already need a CT scan of their chest, abdomen, and pelvis. Participants will have one extra low-rad…

This study is testing a simple blood test that looks for tiny pieces of DNA from the donated organ in the patient's blood. Higher levels of this donor DNA may signal early rejection before damage becomes permanent. The study involves about 1,000 heart or lung transplant patients …

This study works with churches in Washington D.C. to understand heart health in the Black community. About 200 adults will get a health exam, including blood pressure, cholesterol, and blood sugar tests. They will also wear an activity monitor for a month. The results will help d…

This study looks at how small differences in a gene called PKLR might affect red blood cell function and symptoms in people with sickle cell disease. Researchers will collect blood samples from 800 adults of African descent, both with and without sickle cell disease, to analyze g…

This study aims to understand why some people who get a lung transplant develop rejection while others do not. Researchers will follow 100 adults aged 18 to 75 who have had or are waiting for a lung transplant. Participants will have regular check-ups, blood tests, lung function …

This study does not test any new treatments. Instead, it follows people with sickle cell disease over time to learn more about the condition, its complications, and how it affects daily life. Researchers hope to better understand the disease to improve future care. Anyone age 2 o…

This early-stage study tests a new drug called ZMA001 in 96 healthy adults aged 18 to 60. The goal is to check if it is safe and how the body processes it before testing it in people with a serious lung condition called pulmonary arterial hypertension (PAH). Participants receive …

This study follows 155 adults with CADASIL, a genetic condition that narrows small blood vessels and can cause strokes and dementia, over 9 years. Researchers will track changes in blood vessels, brain scans, and thinking abilities through four visits. The goal is to learn how th…

This study tests whether a synbiotic supplement (a powder containing a natural sugar from human milk) can increase helpful gut bacteria in healthy adults. One hundred participants aged 18 and older who eat a typical Western diet and take no regular medications will take the suppl…

This study measures how long red blood cells survive in people with sickle cell disease and other inherited blood disorders. Researchers will label participants' own red blood cells with biotin (a vitamin) and track them over time. The goal is to compare cell survival between peo…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect blood, tissue, and perform imaging tests like MRI and CT scans. The goal is to improve diagnosis and understanding of these conditions. P…

This study aims to understand how platelets—blood cells that help with clotting—function in healthy adults. Researchers will follow 400 volunteers for up to 10 years, collecting blood samples and health information to see how factors like diet, exercise, and genetics affect plate…

This study follows 200 adults with sickle cell disease to see how their heart, brain, kidneys, liver, and lungs improve after treatments meant to cure the disease. Participants either receive curative therapy (like a bone marrow transplant or gene therapy) or standard care. Resea…

This study is for people with genetic conditions affecting the heart or blood vessels, their family members, and healthy volunteers. Researchers will collect medical data, blood, urine, and tissue samples to learn more about these diseases. The goal is to improve diagnosis and un…

This early-phase study looks at how the drug pirtobrutinib changes immune cells in people with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Researchers will enroll 30 adults to take pirtobrutinib daily and will analyze blood and lymph node sam…

This study collects blood, saliva, skin, or tissue samples from people with rare genetic blood vessel or heart diseases, as well as from healthy relatives. The goal is to find the genetic causes and understand how these diseases work. No treatment is given—only samples are taken …

This study tests new, lower-radiation CT scan methods for taking pictures of the heart and blood vessels. Researchers want to see if these new techniques are accurate and can help predict future heart problems like heart attacks or strokes. Up to 5,000 adults who need a heart CT …

This study aims to understand how well vaccines work in people with certain blood cancers like chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphomas. Participants will receive one or more vaccines (e.g., COVID-19, hepatitis B, shingles) and provide blood samples to measure…

This study watches how BTK inhibitors, a type of leukemia treatment, affect the heart's rhythm. About 135 adults with certain blood cancers who are taking or about to start these drugs will have heart tests like EKGs, stress tests, and heart imaging. The goal is to spot dangerous…

This study aims to develop better MRI techniques for imaging the heart and blood vessels. Researchers will scan 5,000 healthy volunteers and people with known or suspected heart disease, ages 7 and older. The goal is to improve diagnosis and understanding of cardiovascular condit…

This study collects blood samples from 1,000 healthy adults aged 18 and older to help researchers understand blood vessel and immune system diseases. Participants donate about 10 tablespoons of blood and may return for up to 10 years. The samples are used to develop tests and stu…

This study follows 1,000 people with bone marrow failure diseases for up to 20 years to learn how the diseases and treatments affect the body over time. Participants aged 2 and older, including family members, will have regular check-ups, blood tests, and other exams. The goal is…

This study follows up to 1,000 adults with certain blood cancers (CLL, SLL, LPL, or WM) to learn how these diseases change over time. Participants get regular check-ups, blood tests, and optional scans or biopsies, but no treatment is given. The goal is to better understand the d…

This study provides long-term follow-up care for people who received a donor stem cell transplant at the NIH. Participants are monitored yearly for late effects, disease relapse, and overall health. The goal is to improve care and understand long-term outcomes for transplant surv…

This study aims to understand why a rare lung disease called LAM destroys lung tissue in women of childbearing age. Researchers will analyze cells, proteins, and genes from up to 2,000 participants to find the root causes. The goal is to pave the way for more effective treatments…

This study looks at how genes play a role in lung diseases like cystic fibrosis, asthma, and pulmonary fibrosis. Researchers will study the DNA of up to 3,500 people with and without lung disease to find genetic differences. The goal is to better understand what causes these dise…

This study collects blood, bone marrow, and cheek cell samples from healthy volunteers ages 8 and older. Researchers use these samples to study blood cell formation, viral blood diseases, immune system function, and genetic risks for aplastic anemia. The goal is to provide essent…

This study is for people aged 5 and older who have a disease related to blood clots, the immune system, or blood vessels, as well as their healthy relatives and unrelated healthy volunteers. The goal is to understand how these conditions start and change over time by collecting m…

This study is testing a new type of MRI scanner that uses less energy than standard machines. The goal is to see if it can still produce clear pictures of the heart, especially for people with metal implants or during procedures using metal tools. About 2,950 healthy adults and p…

This study looks at why people with tuberous sclerosis, a rare genetic condition, develop non-cancerous skin tumors. Researchers will examine skin samples from up to 400 adults to find genetic and protein changes. The goal is to learn more about the disease, not to test a treatme…

This study follows 900 people with bronchiectasis (damaged and infected airways) to learn why they get repeated lung infections. Researchers will collect blood, spit, and genetic samples from patients and their family members. No new treatments are tested; the goal is to find inh…

This study is an early test of a new drug called Fx-5A, which may one day help treat heart disease and inflammation. It involves 64 healthy adults who receive a single dose of the drug and are monitored for safety and side effects over about 5 to 10 weeks. The goal is to gather i…

This study looks at how stress from your neighborhood might affect your heart health. Researchers will track 250 healthy women in Washington, DC for about 2 weeks using a wrist device, GPS, and daily surveys. The goal is to understand how things like crime or lack of parks may in…

This study collects fluid and tissue samples from the lungs and nose of healthy volunteers and people with a history of lung infections. Researchers will compare the samples to find differences in immune function that might explain why some people get lung infections more easily.…

This study follows 306 adults with CHIP or CCUS—conditions where DNA changes in blood cells raise the risk of blood cancers or heart disease. Over 10 years, researchers will track participants with yearly check-ups, blood tests, and scans to see how these changes evolve. The goal…

This study looks for better ways to find lung inflammation early in people who have received a stem cell transplant from a donor. Researchers will use special CT scans, lung washes, and breathing tests before and for two years after the transplant. The goal is to see if these tes…

This study looks at people with lipid disorders—conditions where fats like cholesterol are too high or too low in the blood. Researchers want to learn how these fats cause diseases like hardening of the arteries. Up to 2,000 adults and children (ages 2 and up) will have medical t…

This study aims to develop and test new MRI methods for imaging the heart and blood vessels to improve diagnosis and management of heart failure. It will involve up to 3,400 adults, including both patients with heart conditions and healthy volunteers. Participants will undergo st…

This study aims to learn more about rare genetic disorders that affect fat levels in the blood, such as too much or too little cholesterol or triglycerides. Researchers will follow 1,500 people aged 10 and older for up to 20 years to see how these conditions change and respond to…

This study collects blood stem cells from 500 healthy volunteers to develop better ways to process them for transplants. The goal is to remove the white blood cells that can cause a serious complication called graft-versus-host disease while keeping the stem cells needed for reco…

This study collects blood, bone marrow, urine, and tissue samples from people with cancer or blood disorders, as well as from their healthy family members who are stem cell donors. The samples are used in lab research to better understand diseases, improve treatments, and find ne…

This study looks at genetic changes in chronic lymphocytic leukemia (CLL) patients during treatment with the drug venetoclax. Researchers want to understand how the drug affects cancer cells and the immune system. The study involves 75 adults with relapsed or refractory CLL who w…

This study aims to uncover the genetic causes of severe combined immunodeficiency (SCID), a rare condition where the immune system doesn't work properly. Researchers will collect blood samples from up to 100 patients and their relatives to analyze DNA and other factors. The goal …