Second chance: stem cell transplant trial aims to control sickle cell disease

NCT ID NCT04008368

Recruiting now Disease control Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Source: ClinicalTrials.gov ↗

First seen Nov 12, 2025 · Last updated May 21, 2026 · Updated 25 times

Summary

This study tests a second stem cell transplant for people with sickle cell disease or beta-thalassemia whose first transplant didn't fully work. Participants receive a second infusion of donor stem cells to increase the number of healthy donor cells in their bone marrow. The goal is to control the disease and prevent it from coming back. The study includes 32 people aged 4 and older and their donors.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

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MYELOID CHIMERISM