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Second chance: stem cell transplant aims to rescue sickle cell patients

NCT ID NCT04008368

Recruiting now Disease control Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Source: ClinicalTrials.gov ↗

First seen Nov 12, 2025 · Last updated May 16, 2026 · Updated 23 times

Summary

This study is for people with sickle cell disease or beta-thalassemia whose first stem cell transplant didn't fully work and their disease came back. It offers a second transplant to try to get more donor cells into the bone marrow. Participants will receive drugs to prepare their body and then get donor stem cells, followed by close monitoring for up to 5 years. The goal is to control the disease and prevent rejection of the donor cells.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • National Institutes of Health Clinical Center

    RECRUITING

    Bethesda, Maryland, 20892, United States

    Contact Phone: •••-•••-•••• Email: •••••@•••••

Conditions

Explore the condition pages connected to this study.

MYELOID CHIMERISM