10-Year study tracks hidden DNA changes that raise risk of cancer and heart disease

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* Participants with Clonal Hematopoiesis of Indeterminate Significance (CHIP): INCLUSION CRITERIA: * Greater than or equal to 18 years of age * Willingness and capacity to provide written informed consent * Presence of a somatic pathogenic variant associated with hematological malignancy * Variant allele fraction of greater than or equal to 2% in at least one identified somatic pathogenic variant EXCLUSION CRITERIA: * Known diagnosis of a hematological malignancy or bone marrow failure syndrome (excluding MGUS or MBL) * Presence of a cytopenia: --Hemoglobin, \<10 g/dL; platelet count, \<100 X 10\^9 /L; or absolute neutrophil count, \<1.5 X 10\^9 /L * Pregnant at the time of recruitment Participants with Clonal Cytopenia of Uncertain Significance (CCUS): INCLUSION CRITERIA: * Greater than 18 years of age * Willingness and capacity to provide written informed consent * Presence of a somatic pathogenic variant associated with hematological malignancy without morphological evidence of myelodysplasia and without a MDS defining cytogenetic abnormality * Variant allele fraction of greater than or equal to 2% in at least one identified somatic pathogenic variant * Bone marrow aspirate and biopsy excluding hematological malignancy and MDS * Presence of a cytopenia for \>30 days * Hemoglobin, \<10 g/dL; platelet count, \<100 X10\^9 /L; or absolute neutrophil count, \<1.5 X10\^9 /L * At least 2 CBCs documented in a non-hospitalized patient at least 3 days apart EXCLUSION CRITERIA: * Known diagnosis of a hematological malignancy or bone marrow failure syndrome (excluding MGUS or MBL) * Morphological evidence of dysplasia on bone marrow aspirate / biopsy 10% dysplastic cells in any hematopoietic lineage * Ringed sideroblasts \>15% * Presence of MDS defining cytogenetic abnormality * Del(7q) * del(5q) * 17q or t(17p) * Del(13q) * del(11q) * del(12p) or t(12p) * del(9q) * idic(X)(q13) * t(11;16) * t(3;21) * t(1;3) * t(2;11) * inv(3)/t(3;3) * t(6;9) --Note: As a sole cytogenetic abnormality in the absence of morphological criteria, gain of chromosome 8, del(20q) and loss of chromosome Y are not considered definitive evidence of MDS. * Alternate hematological diagnosis causing cytopenia * Pregnant at time of recruitment