10-Year study tracks hidden DNA changes that raise risk of cancer and heart disease

NCT ID NCT04102423

Recruiting now Knowledge-focused Sponsor: National Heart, Lung, and Blood Institute (NHLBI) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study follows 306 adults with certain DNA changes in their blood cells (called CHIP or CCUS) to see how these changes affect health over time. Researchers want to learn if these changes increase the risk of blood cancers or heart problems. Participants will have yearly check-ups for up to 10 years, including blood tests, heart scans, and other health monitoring.

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Conditions

The condition(s) this trial relates to.

clonal hematopoiesis of indeterminate potential Cytopenia Myelodysplastic Syndromes

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CLONAL CYTOPENIA OF UNDETERMINED SIGNIFICANCE CLONAL HEMATOPOIESIS OF INDETERMINATE POTENTIAL

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••
Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

National Institutes of Health Clinical Center
RECRUITING

Bethesda, Maryland, 20892, United States

Contact Phone: •••-•••-•••• Email: •••••@•••••