Can a targeted drug revive blood cell production in a Pre-Leukemic condition?
NCT ID NCT05030441
First seen Aug 12, 2026 · Last updated Aug 13, 2026 · Updated 1 time
Summary
This trial tests whether ivosidenib, a drug that targets IDH1 mutations, can improve blood counts in people with clonal cytopenia of undetermined significance (CCUS) who have these mutations. CCUS is a condition with low blood counts and an increased risk of developing blood cancers. The study will measure improvements in red blood cells, platelets, and neutrophils after treatment. It also explores whether the drug reduces the proportion of cells carrying the IDH1 mutation.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ivosidenib (Tibsovo), an oral drug that targets IDH1 mutations
- What this could lead to
- If successful, this could offer a targeted treatment to improve blood counts in people with CCUS and IDH1 mutations, potentially slowing or preventing progression to more serious blood disorders.
- What could go wrong
- This is a small pilot study, so results may not be conclusive. The drug may not improve blood counts for everyone, and side effects are possible.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Cleveland Clinic - Case Comprehensive Cancer Center
Cleveland, Ohio, 44195, United States
-
Washington University School of Medicine
St Louis, Missouri, 63110, United States
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