National Heart, Lung, And Blood Institute (nhlbi)

This study tests whether adding a new antibody drug (briquilimab, JSP191) to a standard blood stem cell transplant can help more people with sickle cell disease or beta-thalassemia achieve a full donor cell takeover, potentially curing their condition. About 40 participants aged …

This early-phase study tests a new gene therapy for people with advanced kidney cancer. Doctors take a patient's own white blood cells, modify them in the lab to better attack cancer, and return them to the patient. The main goals are to check safety and see if tumors shrink. The…

This study tests a new combination of drugs and low-dose radiation to make stem cell transplants safer for people with sickle cell disease, even those with organ damage. Six participants aged 16 and older will receive a transplant from a family donor. The goal is to see if the ne…

This study tests a new method called VINTAGE to treat ventricular arrhythmia, a condition where the heart beats abnormally. It is for people whose arrhythmia did not improve with standard treatments. Doctors will use special catheters to reach and destroy hard-to-access parts of …

This study tests whether the drug sirolimus can prevent severe aplastic anemia from coming back after patients stop taking cyclosporine. About 84 people aged 2 and older who have responded to initial treatment will take sirolimus daily for 3 months or receive no extra drug. Resea…

This study tests whether adding eltrombopag to standard immune-suppressing drugs helps people with severe aplastic anemia, a rare condition where the immune system attacks bone marrow. About 207 people aged 2 and older with untreated disease will take eltrombopag for up to 6 mont…

This study looks at the long-term safety of a drug called mitapivat for adults with stable sickle cell disease. Participants, who must have benefited from the drug in a prior study, take mitapivat tablets twice daily for up to 48 weeks, with an option to continue for another 48 w…

This study tests a stem cell transplant using a half-matched family donor for adults with severe sickle cell disease or beta-thalassemia. Instead of high-dose chemotherapy, patients receive low-dose radiation and immune-suppressing drugs to help the donor cells take hold. The goa…

This study tested a combination of two drugs, ibrutinib and fludarabine, in 29 people with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). Participants took ibrutinib daily and received fludarabine for a short time. The goal was to see how many p…

This study aimed to give people who responded well to fostamatinib in an earlier trial continued access to the drug for up to 21 months. The goal was to see if they could maintain stable blood cell levels. However, the study was withdrawn before any participants enrolled.

This study tests a daily pill called PCI-32765 for people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who are over 65 or have a specific genetic change (17p deletion). These groups often don't respond well to standard chemotherapy. The goal is to s…

This study tests a stem cell transplant from a half-matched family donor to treat sickle cell disease in adults. The goal is to see if the new, gentler transplant method is safe and can stop severe complications like strokes. Participants receive low-dose radiation and immune-sup…

This study tests a new procedure called TRAIPTA for people with a leaky tricuspid heart valve who cannot have standard surgery. The procedure places a loop around the heart like a belt to reduce the leak. Researchers will check if it is safe and works well in 60 adults over one y…

This study screens up to 10,000 people with blood disorders or healthy volunteers to see if they can safely join other research studies at the NIH. Participants undergo tests like blood work and imaging. If eligible, they may be offered a spot in an active study; if not, they get…

This study tests whether special low-energy MRI settings can make it safe to use standard guidewires during heart catheterization. Guidewires help doctors position catheters in the heart, but they usually pose a heating risk in MRI machines. The goal is to see if this approach ca…

This study collects blood and other samples from up to 2000 adults with sickle cell disease and healthy volunteers. Researchers will use the samples to study how inflammation affects blood vessels in sickle cell and related diseases. The goal is to better understand these conditi…

This long-term study followed nearly 6,000 adults aged 65 and older to learn what factors predict heart disease, stroke, and related disabilities. Researchers used medical records and exams to identify risks and triggers. The goal was to better understand how to prevent these con…

This study aims to collect blood, urine, and stool samples from 2000 adults with heart failure. Researchers will analyze these samples to find proteins and other factors linked to worsening heart function. Participants have one study visit and are followed via medical records for…

This study gathers medical information from up to 10,000 people with blood or lung conditions, as well as stem cell donors. Researchers will review participants' medical records, test results, and treatments to build a database for future research ideas. The goal is not to test a…

This study follows over 5,000 Black and White adults from age 18-30 for decades to see how their lifestyle and health changes affect heart disease risk later in life. Researchers measure things like blood pressure, weight, and cholesterol over time. The goal is to understand what…

This study looks at blood, bone marrow, and lymph node samples from people with chronic lymphocytic leukemia or Richter syndrome who are receiving epcoritamab. The goal is to learn how the drug affects immune cells and cancer cells over time. Only 5 people are taking part, and th…

This study aims to understand the genetic and molecular changes that occur in people with bone marrow failure disorders, such as aplastic anemia and myelodysplastic syndromes. Researchers will analyze blood and bone marrow samples from up to 1,400 participants aged 2 and older, i…

This long-term study followed over 6,400 adults from different racial and ethnic backgrounds to learn how early signs of heart disease develop and lead to serious events like heart attacks or strokes. Participants were healthy at the start and were monitored for years through exa…

This study tests a new device called the EDEN system that records and analyzes electrical signals from the heart during medical procedures. About 50 adults having heart procedures will use the EDEN system alongside standard equipment. The goal is to see if the system can correctl…

This observational study looks at how the drug mitapivat changes red blood cells in people with sickle cell disease. Researchers will measure how well the cells carry oxygen and how long they survive. The study involves about 6 people already enrolled in a larger trial, with extr…