CARDIOVASCULAR DISEASE

This study tests whether a personalized program—including patient outreach, health education, and financial help—can lower the risk of dying from preventable causes like heart disease, heavy drinking, and HIV. About 87 low-income adults aged 35 to 64 are taking part. The program …

This study tests a new medicine called AZD0780 to see if it safely lowers 'bad' LDL cholesterol in adults who already have heart disease or are at high risk. About 3100 participants will take either the drug or a placebo for 52 weeks, without knowing which they receive. The main …

This study tests whether a probiotic called Probacine can protect the gut and reduce organ damage in 500 adults after heart surgery. Researchers believe that supporting healthy gut bacteria may help prevent complications. Participants will take Probacine and be monitored for gut …

This study tests whether giving evolocumab, a powerful cholesterol-lowering drug, very early during a heart attack hospital stay can reduce the chance of another heart attack, stroke, or death. About 6000 adults hospitalized for a heart attack took part. The drug is added to stan…

This study tests whether pharmacists can help people lower their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity will receive pharmacist-led support. The goal is to see if this approach reduces overall cardiovascular risk wi…

This study tests a weekly injection called CagriSema (cagrilintide plus semaglutide) to see if it can prevent heart attacks, strokes, and other heart-related problems in people who already have heart disease. About 7,100 adults aged 55 and older with a BMI of 25 or higher will re…

This study compares a comprehensive program of lifestyle changes, cholesterol-lowering drugs, and PET heart scans against standard medical care for people with stable coronary artery disease. About 1,085 adults aged 40 and older with suspected or known heart disease are participa…

This study looks at whether taking daily vitamin D or fish oil supplements can lower the risk of developing atrial fibrillation (a type of irregular heartbeat) in healthy adults. Over 25,000 men and women without prior heart disease or stroke are taking part. Researchers are trac…

This large study looked at whether taking daily vitamin D and omega-3 (fish oil) supplements can help prevent cancer, heart disease, and stroke in healthy older adults. Over 25,000 men and women aged 50+ took the supplements for about 5 years. The goal was to see if these common …

This study aims to understand why people of African ancestry have high rates of type 2 diabetes, obesity, and heart disease. Researchers will collect blood samples and health information from 1,100 adults who identify as African American, Afro-Caribbean, or migrants from sub-Saha…

This study follows over 32,000 people who helped clean up the 2010 Deepwater Horizon oil spill or lived in affected areas. Researchers compare their health to people who were not exposed, using medical exams, lab tests, and phone interviews every two years. The goal is to learn a…

This study looks at 433 women who have chest pain but no major blockages in their heart arteries. Researchers want to see if a special MRI scan can detect small artery problems that standard tests miss. Participants get both a standard angiogram and a cardiac MRI, and are followe…

This study explores whether a simple, non-invasive leg movement test can measure blood vessel health in older adults and people with heart disease. Researchers will use ultrasound to see how blood flow changes after a passive leg movement. The goal is to develop a practical tool …

This study is a large registry that collects medical information, lab results, and tissue samples from 30,000 people with heart disease and healthy volunteers. The goal is to analyze risk factors, treatments, and outcomes to better understand cardiovascular disease. Participants …

This study follows over 10,000 healthy adults aged 50-75 for at least 10 years to see how heart rate and blood pressure changes relate to future heart problems, including heart attacks, strokes, and sudden death. Researchers measure heart rate and blood pressure responses during …

This study looks at how ketogenic diets impact heart health in adults with epilepsy. Researchers will measure cholesterol, blood pressure, weight, and artery thickness over 12 months. Participants are adults 18 or older already on a keto diet or starting the modified Atkins diet.…

This study uses advanced heart scans (coronary CT angiography) to understand why people with rheumatoid arthritis face higher risks of heart disease, lung problems, and depression. Researchers will follow 4,000 participants aged 50-75 for up to 10 years, collecting blood samples,…

This study looks at whether people can reliably measure their own physical activity, fitness, and body size at home. Researchers will ask 62 low-risk adults to use step counters, perform a step test, and measure their waist and hips. The goal is to see if these home-based methods…

This study is a review of many smaller trials that looked at what happens when people replace animal proteins (like meat, dairy, eggs) with plant proteins (like beans, nuts, seeds). The goal is to see if this simple swap can improve blood sugar, cholesterol, blood pressure, weigh…

This study looks at how genetic differences influence the way omega-3 fatty acids affect heart disease risk factors. Researchers will measure changes in blood lipids, blood pressure, and other markers in 200 healthy adults aged 18-50 with a BMI between 25 and 40. The goal is to u…

This study follows 1,545 adults over many years to learn how sleep-disordered breathing and other sleep problems develop and affect health. Researchers use overnight sleep tests and questionnaires to track sleep patterns, along with medical exams to measure heart, brain, and mood…

This long-term study follows thousands of Black and white adults in Baltimore to understand how race and income influence health as people age. Researchers collect health data, including heart and brain health, through exams and surveys over many years. The goal is to uncover why…