Milk vs. factory fats: which is worse for your heart?
NCT ID NCT00439582
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at how two types of trans fats—one from milk and one from processed oils—affect heart disease risk. 46 healthy adults ate special foods containing either type of fat for a period, and researchers measured changes in their cholesterol and other blood markers. The goal was to see if natural trans fats are less harmful than industrial ones.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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46 people
- Start date
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Aug 2005
- Completion date
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Dec 2005
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 50 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * HDL cholesterol, g/L \> 0.4 * Triacylglycerol g/L \<1.50 * LDL Cholesterol g/L \<1.60 * Affiliated to National Health Insurance * Waist size \< 102 cm (men) or 88 cm (women) * Normal blood pressure (diastolic \<90 mm Hg, systolic \<140 mm Hg) * Normal liver functions (γ-GT, transaminases, alkaline phosphatase) * Normal white blood cells count (4-10 g/L) * For women: effective contraception * Subject giving his/her written informed consent * Subject willing to comply with the study procedures * Subject considered as normal after clinical examination and medical questionnaire Exclusion Criteria: * Reported food allergies * Currently participating or having participated in another clinical trial during the last 4 weeks prior to the beginning of this study * Hepatic or renal impairments * Positive serologies to HIV or HCV, determined on blood sample * For women, pregnant or presently attempting to get pregnant (-HCG blood test) or menopause or lactating * Blood donation done less than 2 months before the start of the study * Chronic pathologies: diabetes (fasted glycaemia \> 6,1 mmol/L), hypertriglyceridemia (≥1.50 g/L), hypertension (systolic blood pressure ≥ 140 mm Hg and/or diastolic blood pressure ≥ 90 mm Hg), cardiovascular diseases, chronic inflammatory diseases * Intestine, cardiovascular, kidney and cancer pathologies in the last 5 years * Previous heavy intestine surgery (except appendicectomy) * Previous medical and/or surgery judged by the investigator as incompatible with this study * High variation (\> 5%) of body weight during the last 3 months * Consuming nutritional supplements which could interfered with lipid metabolism (fish oil capsule, vitamins, soja lecithins,…) * Heavy consumer of alcohol (evaluated thanks to the values of the following hepatic enzymes: -GT, ASAT, ALAT) * Smoker or ex-smoker who stopped smoking less than 1 month before V0 * Practicing intensive physical exercise (\> 3 h per week) * Vegetarian or vegan * Taking medication for depressive or psychiatric state * Being under someone's supervision * Refusal to be registered on the National Volunteers Data file * Disliking butter, margarine, cheese, biscuits and/or vegetable oil * Dietary habits unreliable to controlled food intake * Being in exclusion on the National Volunteers Data file
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Centre de Recherche en Nutrition Humaine (CRNH), UEN, Laboratoire de Nutrition Humaine
Clermont-Ferrand, 63009, France
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