Could everyday supplements turn back the clock on aging?
NCT ID NCT07760506
First seen Aug 12, 2026 · Last updated Sep 18, 2026 · Updated 3 times
Summary
This trial tests whether two natural supplements—quercetin (from foods like apples and onions) and coenzyme Q10 (a substance your body makes)—can reduce inflammation and improve metabolic health in older adults. Over 12 weeks, participants aged 50 to 75 who are sedentary will take either one of the supplements or a placebo twice daily. Researchers will measure markers of biological aging, blood sugar, cholesterol, grip strength, and quality of life to see if these supplements offer any benefits.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Quercetin (Quercefit) and Coenzyme Q10 (Ubiqsome) dietary supplements
- What this could lead to
- If effective, these supplements could offer a simple way to support healthy aging by reducing inflammation and improving blood sugar and cholesterol in older adults.
- What could go wrong
- This is a small, early-stage trial, and supplements may not produce meaningful benefits. Side effects are possible, and results may not apply to everyone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Sep 2026
An estimate. Start dates often move.
- Expected to finish
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Aug 2028
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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50 to 75 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Males and females aged 50 to 75 years * Participants who meet the requirements of a sedentary lifestyle. Meaning, subjects who do not meet the World Health Organization's (WHO) minimum activity guidelines, of at least 150 minutes of moderate-intensity activity, or, 75 minutes of vigorous-intensity activity a week, plus muscle-strengthening activities at least 2 days per week. Of importance, incidental physical activity (eg, walking to work, household activities) would not meet the standard of being physically active according to WHO guidelines (McKay et al., 2021). * BMI of \> or equal to 25.00kg/m² * Individuals with \> or equal to 5 score relative to high risk for prediabetes as defined by the CDC (https://www.cdc.gov/prediabetes/takethetest) * Free of all other chronic diseases. * Not currently using glucose-lowering agents or insulin. * Able to read and write in English * Willing to maintain a habitual diet, supplement routine, and avoid other lifestyle changes during the study period. * During the study, participants agree not to take any other supplement that can impact glucose or insulin regulation. * During the study, participants agree not to take any other supplement that can impact cardiovascular health, inflammatory status, or anti-aging supplements * Willing to have blood drawn * Must have access to a reliable internet connection and a computer to complete remote assessments Exclusion Criteria: * Unwilling to have blood drawn * Unwilling to swallow pills * Pregnancy or has breast fed within 3 months prior to enrollment * Current use of prescription medication or drug that impacts Glucose or Insulin metabolism (including direct insulin treatment) within the past 6-months * Current use of Quercetine or CoQ10 supplements within the past 4-weeks * History or current alcohol or drug abuse * Known diagnosis of any chronic cardiovascular, metabolic, endocrine, or renal disease outside of prediabetes as listed above. * Has significant concurrent illnesses (controlled or uncontrolled), such as lupus, hepatitis B/C, HIV, serious mental health illness such as dementia or schizophrenia; psychiatric hospitalization in the past two years, or other conditions, which in the opinion of the investigator, such condition might be aggravated as a result of treatment * Developmental disability or cognitive impairment that would preclude adequate comprehension of the informed consent form and/or ability to follow study subject requirements and/or record the necessary study measurements. * History of cardiovascular disease (i.e., myocardial infarction, hypertension, hypercholesterolemia, peripheral vascular disease, other) * History of neurological disorders (Parkinson's, Amyotrophic lateral sclerosis, epilepsy, spinal cord injury resulting in inability to use upper extremities, other.) * History of gastrointestinal disorders that could lead to uncertain absorption of the study supplements (i.e., inflammatory bowel disease, ulcerative colitis, -Crohn's disease, colostomy, or eating disorder) * History of kidney or liver disease * History of metabolic disorders (diabetes, metabolic syndrome, other) * History of current malignancy/cancer * Receiving chemotherapy agents or radiation treatments * Diagnosis of a terminal illness * The investigator feels that, for any reason, the subject is not eligible to participate in the study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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The Applied Science and Performance Institute
RECRUITINGTampa, Florida, 33634, United States
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